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Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans.
Clin Neurophysiol. 2012 Jul; 123(7):1415-21.CN

Abstract

OBJECTIVE

Quadripulse transcranial magnetic stimulation (QPS) is a newly designed patterned repetitive transcranial magnetic stimulation (TMS). Previous studies of QPS showed bidirectional effects on the primary motor cortex (M1), which depended on its inter-stimulus interval (ISI): motor evoked potentials (MEPs) were potentiated at short ISIs and depressed at long ISIs (homotopic effects). These physiological characters were compatible with synaptic plasticity. In this research, we studied effects of QPS on the primary sensory cortex (S1).

METHODS

One burst consisted of four monophasic TMS pulses at an intensity of 90% active motor threshold. The ISI of four pulses was set at 5 ms (QPS-5) or at 50 ms (QPS-50). Same bursts were given every 5s for 30 min. QPS-5 and QPS-50 were performed over three areas (M1, S1 and dorsal premotor cortex (dPMC)). One sham stimulation session was also performed. Excitability changes of S1 were evaluated by timeline of somatosensory evoked potentials (SEPs).

RESULTS

QPS-5 over M1 or dPMC enhanced the P25-N33 component of SEP, and QPS-50 over M1 depressed it. By contrast, QPSs over S1 had no effects on SEPs.

CONCLUSIONS

QPSs over motor cortices modulated the S1 cortical excitability (heterotopic effects). Mutual connections between dPMC or M1 and S1 might be responsible for these modulations.

SIGNIFICANCE

QPSs induced heterotopic LTP or LTD-like cortical excitability changes.

Authors+Show Affiliations

Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan. setsu-tky@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22280937

Citation

Nakatani-Enomoto, Setsu, et al. "Bidirectional Modulation of Sensory Cortical Excitability By Quadripulse Transcranial Magnetic Stimulation (QPS) in Humans." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 123, no. 7, 2012, pp. 1415-21.
Nakatani-Enomoto S, Hanajima R, Hamada M, et al. Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans. Clin Neurophysiol. 2012;123(7):1415-21.
Nakatani-Enomoto, S., Hanajima, R., Hamada, M., Terao, Y., Matsumoto, H., Shirota, Y., Okabe, S., Hirose, M., Nakamura, K., Furubayashi, T., Kobayashi, S., Mochizuki, H., Enomoto, H., & Ugawa, Y. (2012). Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 123(7), 1415-21. https://doi.org/10.1016/j.clinph.2011.11.037
Nakatani-Enomoto S, et al. Bidirectional Modulation of Sensory Cortical Excitability By Quadripulse Transcranial Magnetic Stimulation (QPS) in Humans. Clin Neurophysiol. 2012;123(7):1415-21. PubMed PMID: 22280937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans. AU - Nakatani-Enomoto,Setsu, AU - Hanajima,Ritstuko, AU - Hamada,Masashi, AU - Terao,Yasuo, AU - Matsumoto,Hideyuki, AU - Shirota,Yuichiro, AU - Okabe,Shingo, AU - Hirose,Masaki, AU - Nakamura,Koichiro, AU - Furubayashi,Toshiaki, AU - Kobayashi,Shunsuke, AU - Mochizuki,Hitoshi, AU - Enomoto,Hiroyuki, AU - Ugawa,Yoshikazu, Y1 - 2012/01/26/ PY - 2011/05/01/received PY - 2011/11/14/revised PY - 2011/11/23/accepted PY - 2012/1/28/entrez PY - 2012/1/28/pubmed PY - 2012/9/12/medline SP - 1415 EP - 21 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 123 IS - 7 N2 - OBJECTIVE: Quadripulse transcranial magnetic stimulation (QPS) is a newly designed patterned repetitive transcranial magnetic stimulation (TMS). Previous studies of QPS showed bidirectional effects on the primary motor cortex (M1), which depended on its inter-stimulus interval (ISI): motor evoked potentials (MEPs) were potentiated at short ISIs and depressed at long ISIs (homotopic effects). These physiological characters were compatible with synaptic plasticity. In this research, we studied effects of QPS on the primary sensory cortex (S1). METHODS: One burst consisted of four monophasic TMS pulses at an intensity of 90% active motor threshold. The ISI of four pulses was set at 5 ms (QPS-5) or at 50 ms (QPS-50). Same bursts were given every 5s for 30 min. QPS-5 and QPS-50 were performed over three areas (M1, S1 and dorsal premotor cortex (dPMC)). One sham stimulation session was also performed. Excitability changes of S1 were evaluated by timeline of somatosensory evoked potentials (SEPs). RESULTS: QPS-5 over M1 or dPMC enhanced the P25-N33 component of SEP, and QPS-50 over M1 depressed it. By contrast, QPSs over S1 had no effects on SEPs. CONCLUSIONS: QPSs over motor cortices modulated the S1 cortical excitability (heterotopic effects). Mutual connections between dPMC or M1 and S1 might be responsible for these modulations. SIGNIFICANCE: QPSs induced heterotopic LTP or LTD-like cortical excitability changes. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/22280937/Bidirectional_modulation_of_sensory_cortical_excitability_by_quadripulse_transcranial_magnetic_stimulation__QPS__in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(11)00832-7 DB - PRIME DP - Unbound Medicine ER -