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Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk.
Osteoporos Int 2012; 23(5):1563-70OI

Abstract

Eighteen months of daily consumption of milk containing 250 mg calcium prevented bone mineral density (BMD) loss at the hip and the femoral neck in postmenopausal Chinese women aged 45 to 65.

INTRODUCTION

Estrogen-related bone loss in postmenopausal women can be prevented by the consumption of milk with high doses of calcium and soymilk with high doses of isoflavones. However, high doses of calcium and isoflavones may not be necessary to attain a beneficial effect of milk and soymilk on BMD. We hypothesized that BMD will increase in postmenopausal Chinese women who consume daily 250 mg calcium in milk or soymilk. Milk prevented bone loss at the hip and the femoral neck in postmenopausal Chinese women.

METHODS

A total of 141 eligible Chinese women without osteoporosis, aged 45-65, and postmenopausal for more than 2 years were randomized into groups receiving for 18 months (A) milk with 250 mg calcium daily, (B) soymilk with 250 mg calcium daily, or (C) neither milk nor soymilk. Dual-energy X-ray absorptiometry measured the BMD of the spine and hip at 0, 6, 12, and 18 months.

RESULTS

The BMD in the hip (2.52%) and the femoral neck (2.82%) of the women consuming milk was significantly higher (hip, P = 0.01; femoral neck, P < 0.0000001). The women in the control group experienced a reduction in BMD at all sites; the reduction in BMD was only significant at the hip during 12 months (P = 0.008) and at the femoral neck during 18 months (P = 0.005).

CONCLUSIONS

Daily consumption of milk containing 250 mg calcium over 18 months prevents BMD loss at the hip and the femoral neck in postmenopausal Chinese women.

Authors+Show Affiliations

Department of Nuclear Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai 200040, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22282300

Citation

Gui, J-C, et al. "Bone Mineral Density in Postmenopausal Chinese Women Treated With Calcium Fortification in Soymilk and Cow's Milk." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 23, no. 5, 2012, pp. 1563-70.
Gui JC, Brašić JR, Liu XD, et al. Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk. Osteoporos Int. 2012;23(5):1563-70.
Gui, J. C., Brašić, J. R., Liu, X. D., Gong, G. Y., Zhang, G. M., Liu, C. J., & Gao, G. Q. (2012). Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 23(5), pp. 1563-70. doi:10.1007/s00198-012-1895-z.
Gui JC, et al. Bone Mineral Density in Postmenopausal Chinese Women Treated With Calcium Fortification in Soymilk and Cow's Milk. Osteoporos Int. 2012;23(5):1563-70. PubMed PMID: 22282300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk. AU - Gui,J-C, AU - Brašić,J R, AU - Liu,X-D, AU - Gong,G-Y, AU - Zhang,G-M, AU - Liu,C-J, AU - Gao,G-Q, Y1 - 2012/01/27/ PY - 2010/10/23/received PY - 2011/05/16/accepted PY - 2012/1/28/entrez PY - 2012/1/28/pubmed PY - 2012/8/21/medline SP - 1563 EP - 70 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 23 IS - 5 N2 - UNLABELLED: Eighteen months of daily consumption of milk containing 250 mg calcium prevented bone mineral density (BMD) loss at the hip and the femoral neck in postmenopausal Chinese women aged 45 to 65. INTRODUCTION: Estrogen-related bone loss in postmenopausal women can be prevented by the consumption of milk with high doses of calcium and soymilk with high doses of isoflavones. However, high doses of calcium and isoflavones may not be necessary to attain a beneficial effect of milk and soymilk on BMD. We hypothesized that BMD will increase in postmenopausal Chinese women who consume daily 250 mg calcium in milk or soymilk. Milk prevented bone loss at the hip and the femoral neck in postmenopausal Chinese women. METHODS: A total of 141 eligible Chinese women without osteoporosis, aged 45-65, and postmenopausal for more than 2 years were randomized into groups receiving for 18 months (A) milk with 250 mg calcium daily, (B) soymilk with 250 mg calcium daily, or (C) neither milk nor soymilk. Dual-energy X-ray absorptiometry measured the BMD of the spine and hip at 0, 6, 12, and 18 months. RESULTS: The BMD in the hip (2.52%) and the femoral neck (2.82%) of the women consuming milk was significantly higher (hip, P = 0.01; femoral neck, P < 0.0000001). The women in the control group experienced a reduction in BMD at all sites; the reduction in BMD was only significant at the hip during 12 months (P = 0.008) and at the femoral neck during 18 months (P = 0.005). CONCLUSIONS: Daily consumption of milk containing 250 mg calcium over 18 months prevents BMD loss at the hip and the femoral neck in postmenopausal Chinese women. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/22282300/Bone_mineral_density_in_postmenopausal_Chinese_women_treated_with_calcium_fortification_in_soymilk_and_cow's_milk_ L2 - https://dx.doi.org/10.1007/s00198-012-1895-z DB - PRIME DP - Unbound Medicine ER -