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Diagnosis and management of cow's milk protein allergy in infants.
World J Pediatr. 2012 Feb; 8(1):19-24.WJ

Abstract

BACKGROUND

Cow's milk protein allergy (CMPA) is frequently suspected in infants with a variety of symptoms. A thorough history and careful clinical examination are necessary to exclude other underlying diseases and to evaluate the severity of the suspected allergy. Care should be taken to diagnose CMPA adequately to avoid an unnecessary diet.

DATA SOURCES

We make recommendations based on systematic literature searches using the best-available evidence from PubMed, Cumulative Index to Nursing and Allied Health Literature, and bibliographies.

RESULTS

Skin prick tests, patch tests and serum specific IgE are only indicative of CMPA. Breastfed infants have a decreased risk of developing CMPA; an elimination diet for the mother is indicated if CMPA is confirmed. If a food challenge is positive in formula fed infants, an extensively hydrolysed formula and cow's milk-free diet is recommended. If symptoms do not improve, an amino acid based formula should be considered. In severe CMPA with life-threatening symptoms, an amino-acid formula is recommended.

CONCLUSIONS

Elimination diet by a double-blind placebo controlled food challenge is the gold standard for diagnosis. Elimination of the offending allergen from the infants' diet is the main treatment principle.

Authors+Show Affiliations

Department of Pediatrics, UZ Brussel, Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22282379

Citation

De Greef, Elisabeth, et al. "Diagnosis and Management of Cow's Milk Protein Allergy in Infants." World Journal of Pediatrics : WJP, vol. 8, no. 1, 2012, pp. 19-24.
De Greef E, Hauser B, Devreker T, et al. Diagnosis and management of cow's milk protein allergy in infants. World J Pediatr. 2012;8(1):19-24.
De Greef, E., Hauser, B., Devreker, T., Veereman-Wauters, G., & Vandenplas, Y. (2012). Diagnosis and management of cow's milk protein allergy in infants. World Journal of Pediatrics : WJP, 8(1), 19-24. https://doi.org/10.1007/s12519-012-0332-x
De Greef E, et al. Diagnosis and Management of Cow's Milk Protein Allergy in Infants. World J Pediatr. 2012;8(1):19-24. PubMed PMID: 22282379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and management of cow's milk protein allergy in infants. AU - De Greef,Elisabeth, AU - Hauser,Bruno, AU - Devreker,Thierry, AU - Veereman-Wauters,Gigi, AU - Vandenplas,Yvan, Y1 - 2012/01/27/ PY - 2011/06/28/received PY - 2011/09/08/accepted PY - 2012/1/28/entrez PY - 2012/1/28/pubmed PY - 2012/6/20/medline SP - 19 EP - 24 JF - World journal of pediatrics : WJP JO - World J Pediatr VL - 8 IS - 1 N2 - BACKGROUND: Cow's milk protein allergy (CMPA) is frequently suspected in infants with a variety of symptoms. A thorough history and careful clinical examination are necessary to exclude other underlying diseases and to evaluate the severity of the suspected allergy. Care should be taken to diagnose CMPA adequately to avoid an unnecessary diet. DATA SOURCES: We make recommendations based on systematic literature searches using the best-available evidence from PubMed, Cumulative Index to Nursing and Allied Health Literature, and bibliographies. RESULTS: Skin prick tests, patch tests and serum specific IgE are only indicative of CMPA. Breastfed infants have a decreased risk of developing CMPA; an elimination diet for the mother is indicated if CMPA is confirmed. If a food challenge is positive in formula fed infants, an extensively hydrolysed formula and cow's milk-free diet is recommended. If symptoms do not improve, an amino acid based formula should be considered. In severe CMPA with life-threatening symptoms, an amino-acid formula is recommended. CONCLUSIONS: Elimination diet by a double-blind placebo controlled food challenge is the gold standard for diagnosis. Elimination of the offending allergen from the infants' diet is the main treatment principle. SN - 1867-0687 UR - https://www.unboundmedicine.com/medline/citation/22282379/Diagnosis_and_management_of_cow's_milk_protein_allergy_in_infants_ L2 - https://dx.doi.org/10.1007/s12519-012-0332-x DB - PRIME DP - Unbound Medicine ER -