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Hepatitis C virus infection in patients with tuberculosis in Central Brazil.
Int J Tuberc Lung Dis. 2011 Oct; 15(10):1397-402.IJ

Abstract

SETTING

Goiânia City, Goiás State, Brazil.

OBJECTIVES

To determine the prevalence of hepatitis C virus (HCV) infection, risk factors, HCV genotype/ subtype, HCV viral load and human immunodeficiency virus (HIV) status in patients with tuberculosis (TB) in Central Brazil.

DESIGN

A cross-sectional study was carried out with 402 patients who were under tuberculosis (TB) treatment in the reference hospital for infectious diseases in Goiânia, Goiás, Central Brazil.

RESULTS

The prevalence rates of HCV and HIV were respectively 7.5% and 27.6%. Two thirds of the HCV-infected patients (20/30) were HIV-positive. Age, injecting drug use (IDU) and HIV status were factors independently associated with HCV infection. HCV RNA was detected in 23 serum samples; HCV RNA levels were measured in 22/23 samples. HCV RNA level was slightly higher in HCV-HIV co-infected patients than in HCV monoinfected patients. Genotypes 1 (n = 17) and 3 (n = 6) were determined by LiPA. Using phylogenetic tree analysis of the NS5B region, subtypes 1a (n = 12), 1b (n = 2) and 3a (n = 6) were identified.

CONCLUSION

These data indicate that patients with TB may benefit from integrated HIV and HCV screening, which may have an important impact upon TB management and treatment.

Authors+Show Affiliations

Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goás, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22283901

Citation

Reis, N R S., et al. "Hepatitis C Virus Infection in Patients With Tuberculosis in Central Brazil." The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, vol. 15, no. 10, 2011, pp. 1397-402.
Reis NR, Lopes CL, Teles SA, et al. Hepatitis C virus infection in patients with tuberculosis in Central Brazil. Int J Tuberc Lung Dis. 2011;15(10):1397-402.
Reis, N. R., Lopes, C. L., Teles, S. A., Matos, M. A., Carneiro, M. A., Marinho, T. A., Filho, J. A., Espírito-Santo, M. P., Lampe, E., & Martins, R. M. (2011). Hepatitis C virus infection in patients with tuberculosis in Central Brazil. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease, 15(10), 1397-402. https://doi.org/10.5588/ijtld.10.0636
Reis NR, et al. Hepatitis C Virus Infection in Patients With Tuberculosis in Central Brazil. Int J Tuberc Lung Dis. 2011;15(10):1397-402. PubMed PMID: 22283901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C virus infection in patients with tuberculosis in Central Brazil. AU - Reis,N R S, AU - Lopes,C L R, AU - Teles,S A, AU - Matos,M A D, AU - Carneiro,M A S, AU - Marinho,T A, AU - Filho,J A Araújo, AU - Espírito-Santo,M P, AU - Lampe,E, AU - Martins,R M B, PY - 2012/1/31/entrez PY - 2012/1/31/pubmed PY - 2012/5/19/medline SP - 1397 EP - 402 JF - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JO - Int J Tuberc Lung Dis VL - 15 IS - 10 N2 - SETTING: Goiânia City, Goiás State, Brazil. OBJECTIVES: To determine the prevalence of hepatitis C virus (HCV) infection, risk factors, HCV genotype/ subtype, HCV viral load and human immunodeficiency virus (HIV) status in patients with tuberculosis (TB) in Central Brazil. DESIGN: A cross-sectional study was carried out with 402 patients who were under tuberculosis (TB) treatment in the reference hospital for infectious diseases in Goiânia, Goiás, Central Brazil. RESULTS: The prevalence rates of HCV and HIV were respectively 7.5% and 27.6%. Two thirds of the HCV-infected patients (20/30) were HIV-positive. Age, injecting drug use (IDU) and HIV status were factors independently associated with HCV infection. HCV RNA was detected in 23 serum samples; HCV RNA levels were measured in 22/23 samples. HCV RNA level was slightly higher in HCV-HIV co-infected patients than in HCV monoinfected patients. Genotypes 1 (n = 17) and 3 (n = 6) were determined by LiPA. Using phylogenetic tree analysis of the NS5B region, subtypes 1a (n = 12), 1b (n = 2) and 3a (n = 6) were identified. CONCLUSION: These data indicate that patients with TB may benefit from integrated HIV and HCV screening, which may have an important impact upon TB management and treatment. SN - 1815-7920 UR - https://www.unboundmedicine.com/medline/citation/22283901/Hepatitis_C_virus_infection_in_patients_with_tuberculosis_in_Central_Brazil_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1027-3719&volume=15&issue=10&spage=1397&aulast=Reis DB - PRIME DP - Unbound Medicine ER -