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Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects.
J Ethnopharmacol. 2012 Mar 27; 140(2):261-70.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Scorzonera species are mainly used against inflammation and to relieve pain in Turkish traditional medicine. Therefore, we aimed to assess in vivo anti-inflammatory and antinociceptive activities of the aerial part and root extracts of Scorzonera acuminata, Scorzonera cana var. alpina, Scorzonera cana var. jacquiniana, Scorzonera cana var. radicosa, Scorzonera cinerea, Scorzonera eriophora, Scorzonera incisa, Scorzonera laciniata ssp. laciniata, Scorzonera parviflora and Scorzonera sublanata.

MATERIALS AND METHODS

For the anti-inflammatory activity evaluation carrageenan, PGE(2) and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models were used. p-Benzoquinone-induced abdominal constriction test was employed in mice for the assessment of antinociceptive activity. Furthermore chemical composition of the tested extracts was investigated qualitatively and quantitatively by using RP-HPLC method. Some phenolic acids and flavonoids were used as standards.

RESULTS

Extracts prepared from the aerial parts of Scorzonera cana var. jacquiniana, Scorzonera cinerea, Scorzonera eriophora, Scorzonera incisa and Scorzonera parviflora showed significant inhibitory effect on carrageenan and PGE(2)-induced hind paw edema model as well as on p-benzoquinone-induced abdominal constriction test. The extracts did not show any remarkable activity on serotonin-induced hind paw edema and TPA-induced mouse ear edema models. Chlorogenic acid was detected as major compounds in all the species investigated. Additionally, among the tested flavonoids, luteolin-7-glucoside, hyperoside and rutin were found to be in different amounts in Scorzonera species.

CONCLUSION

The experimental data revealed that Scorzonera cana var. jacquiniana, Scorzonera cinerea, Scorzonera eriophora, Scorzonera incisa and Scorzonera parviflora possess significant anti-inflammatory and antinociceptive activity. It has been suggested that flavonoids and chlorogenic acid are partly responsible for mentioned activities of Scorzonera species.

Authors+Show Affiliations

Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler 06330 Ankara, Turkey. esrak@gazi.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22285519

Citation

Küpeli Akkol, Esra, et al. "Ethnopharmacological Evaluation of some Scorzonera Species: in Vivo Anti-inflammatory and Antinociceptive Effects." Journal of Ethnopharmacology, vol. 140, no. 2, 2012, pp. 261-70.
Küpeli Akkol E, Bahadır Acıkara O, Süntar I, et al. Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects. J Ethnopharmacol. 2012;140(2):261-70.
Küpeli Akkol, E., Bahadır Acıkara, O., Süntar, I., Ergene, B., & Saltan Çitoğlu, G. (2012). Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects. Journal of Ethnopharmacology, 140(2), 261-70. https://doi.org/10.1016/j.jep.2012.01.015
Küpeli Akkol E, et al. Ethnopharmacological Evaluation of some Scorzonera Species: in Vivo Anti-inflammatory and Antinociceptive Effects. J Ethnopharmacol. 2012 Mar 27;140(2):261-70. PubMed PMID: 22285519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects. AU - Küpeli Akkol,Esra, AU - Bahadır Acıkara,Ozlem, AU - Süntar,Ipek, AU - Ergene,Burçin, AU - Saltan Çitoğlu,Gülçin, Y1 - 2012/01/20/ PY - 2011/08/16/received PY - 2011/12/22/revised PY - 2012/01/11/accepted PY - 2012/1/31/entrez PY - 2012/1/31/pubmed PY - 2012/8/3/medline SP - 261 EP - 70 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 140 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Scorzonera species are mainly used against inflammation and to relieve pain in Turkish traditional medicine. Therefore, we aimed to assess in vivo anti-inflammatory and antinociceptive activities of the aerial part and root extracts of Scorzonera acuminata, Scorzonera cana var. alpina, Scorzonera cana var. jacquiniana, Scorzonera cana var. radicosa, Scorzonera cinerea, Scorzonera eriophora, Scorzonera incisa, Scorzonera laciniata ssp. laciniata, Scorzonera parviflora and Scorzonera sublanata. MATERIALS AND METHODS: For the anti-inflammatory activity evaluation carrageenan, PGE(2) and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models were used. p-Benzoquinone-induced abdominal constriction test was employed in mice for the assessment of antinociceptive activity. Furthermore chemical composition of the tested extracts was investigated qualitatively and quantitatively by using RP-HPLC method. Some phenolic acids and flavonoids were used as standards. RESULTS: Extracts prepared from the aerial parts of Scorzonera cana var. jacquiniana, Scorzonera cinerea, Scorzonera eriophora, Scorzonera incisa and Scorzonera parviflora showed significant inhibitory effect on carrageenan and PGE(2)-induced hind paw edema model as well as on p-benzoquinone-induced abdominal constriction test. The extracts did not show any remarkable activity on serotonin-induced hind paw edema and TPA-induced mouse ear edema models. Chlorogenic acid was detected as major compounds in all the species investigated. Additionally, among the tested flavonoids, luteolin-7-glucoside, hyperoside and rutin were found to be in different amounts in Scorzonera species. CONCLUSION: The experimental data revealed that Scorzonera cana var. jacquiniana, Scorzonera cinerea, Scorzonera eriophora, Scorzonera incisa and Scorzonera parviflora possess significant anti-inflammatory and antinociceptive activity. It has been suggested that flavonoids and chlorogenic acid are partly responsible for mentioned activities of Scorzonera species. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22285519/Ethnopharmacological_evaluation_of_some_Scorzonera_species:_in_vivo_anti_inflammatory_and_antinociceptive_effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00028-1 DB - PRIME DP - Unbound Medicine ER -