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Early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema: an ISAAC Phase Three Study.
Int J Epidemiol. 2012 Jun; 41(3):753-61.IJ

Abstract

BACKGROUND

Associations between early life exposure to farm animals and respiratory symptoms and allergy in children have been reported in developed countries, but little is known about such associations in developing countries.

OBJECTIVE

To study the association between early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema in a worldwide study.

METHODS

Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) was carried out in 6- to 7-year-old children in urban populations across the world. Questions about early life exposure to farm animals (at least once/week) were included in an additional questionnaire. The association between such exposures and symptoms of asthma, rhinoconjunctivitis and eczema was investigated with logistic regression. Adjustments were made for gender, region of the world, language, gross national income and 10 other subject-specific covariates.

RESULTS

A positive association was found between early exposure to farm animals and the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, especially in non-affluent countries. In these countries, odds ratios (ORs) for 'current wheeze', 'farm animal exposure in the first year of life' and 'farm animal exposure in pregnancy' were 1.27 [95% confidence interval (CI) 1.12-1.44] and 1.38 (95% CI 1.21-1.58), respectively. The corresponding ORs for affluent countries were 0.96 (95% CI 0.86-1.08) and 0.95 (95% CI 0.84-1.08), respectively.

CONCLUSION

Exposure to farm animals during pregnancy and in the first year of life was associated with increased symptoms of asthma, rhinoconjunctivitis and eczema in 6- to 7-year-old children living in non-affluent but not in affluent countries.

Authors+Show Affiliations

Institute for Risk Assessment Sciences and Julius Center for Health Sciences and Primary Care, University Medical Center Universiteit Utrecht, Utrecht, The Netherlands. b.brunekreef@uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22287135

Citation

Brunekreef, Bert, et al. "Early Life Exposure to Farm Animals and Symptoms of Asthma, Rhinoconjunctivitis and Eczema: an ISAAC Phase Three Study." International Journal of Epidemiology, vol. 41, no. 3, 2012, pp. 753-61.
Brunekreef B, Von Mutius E, Wong GK, et al. Early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema: an ISAAC Phase Three Study. Int J Epidemiol. 2012;41(3):753-61.
Brunekreef, B., Von Mutius, E., Wong, G. K., Odhiambo, J. A., & Clayton, T. O. (2012). Early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema: an ISAAC Phase Three Study. International Journal of Epidemiology, 41(3), 753-61. https://doi.org/10.1093/ije/dyr216
Brunekreef B, et al. Early Life Exposure to Farm Animals and Symptoms of Asthma, Rhinoconjunctivitis and Eczema: an ISAAC Phase Three Study. Int J Epidemiol. 2012;41(3):753-61. PubMed PMID: 22287135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema: an ISAAC Phase Three Study. AU - Brunekreef,Bert, AU - Von Mutius,Erika, AU - Wong,Gary K, AU - Odhiambo,Joseph A, AU - Clayton,Tadd O, AU - ,, Y1 - 2012/01/27/ PY - 2012/1/31/entrez PY - 2012/1/31/pubmed PY - 2012/12/10/medline SP - 753 EP - 61 JF - International journal of epidemiology JO - Int J Epidemiol VL - 41 IS - 3 N2 - BACKGROUND: Associations between early life exposure to farm animals and respiratory symptoms and allergy in children have been reported in developed countries, but little is known about such associations in developing countries. OBJECTIVE: To study the association between early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema in a worldwide study. METHODS: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) was carried out in 6- to 7-year-old children in urban populations across the world. Questions about early life exposure to farm animals (at least once/week) were included in an additional questionnaire. The association between such exposures and symptoms of asthma, rhinoconjunctivitis and eczema was investigated with logistic regression. Adjustments were made for gender, region of the world, language, gross national income and 10 other subject-specific covariates. RESULTS: A positive association was found between early exposure to farm animals and the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, especially in non-affluent countries. In these countries, odds ratios (ORs) for 'current wheeze', 'farm animal exposure in the first year of life' and 'farm animal exposure in pregnancy' were 1.27 [95% confidence interval (CI) 1.12-1.44] and 1.38 (95% CI 1.21-1.58), respectively. The corresponding ORs for affluent countries were 0.96 (95% CI 0.86-1.08) and 0.95 (95% CI 0.84-1.08), respectively. CONCLUSION: Exposure to farm animals during pregnancy and in the first year of life was associated with increased symptoms of asthma, rhinoconjunctivitis and eczema in 6- to 7-year-old children living in non-affluent but not in affluent countries. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/22287135/Early_life_exposure_to_farm_animals_and_symptoms_of_asthma_rhinoconjunctivitis_and_eczema:_an_ISAAC_Phase_Three_Study_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyr216 DB - PRIME DP - Unbound Medicine ER -