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Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats.
Toxicol Ind Health. 2013 Feb; 29(1):3-13.TI

Abstract

Neuropathic pain is a chronic neurodegenerative disease. It is well characterized by spontaneous pain, hyperalgesia, hypothesia, dysesthesia and allodynia. The present study was designed to investigate the antinociceptive potential of Butea monosperma on vincristine-induced painful neuropathy in rats. Vincristine was administered for induction of neuropathic pain in experimental animals. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia and allodynia in the hind paw and tail thermal hyperalgesia, respectively, as an index of peripheral and central pain sensation. Tissue thiobarbituric acid reactive substances (TBARSs), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Microscopically, histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of B. monosperma leaves and pregabalin were administered for 14 consecutive days. Vincristine administration resulted in significant reduction in behavioural (i.e. hyperalgesia and allodynic pain sensation) changes along with a rise in the levels of TBARS, total calcium and decrease in GSH levels when compared with the normal control group. Moreover, significant histological changes were also observed. Pretreatment with B. monosperma significantly attenuated vincristine-induced development of painful behavioural, biochemical and histological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. B. monosperma ameliorated vincristine-induced painful neuropathy. It may be due to its potential of antioxidative, neuroprotective and calcium channel inactivation.

Authors+Show Affiliations

School of Chemical and Biotechnology, Sastra University, Thanjavur, Tamilnadu, India. vrkmmcmadurai@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22287618

Citation

Thiagarajan, Venkata Rathina Kumar, et al. "Antinociceptive Effect of Butea Monosperma On Vincristine-induced Neuropathic Pain Model in Rats." Toxicology and Industrial Health, vol. 29, no. 1, 2013, pp. 3-13.
Thiagarajan VR, Shanmugam P, Krishnan UM, et al. Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats. Toxicol Ind Health. 2013;29(1):3-13.
Thiagarajan, V. R., Shanmugam, P., Krishnan, U. M., Muthuraman, A., & Singh, N. (2013). Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats. Toxicology and Industrial Health, 29(1), 3-13. https://doi.org/10.1177/0748233711432573
Thiagarajan VR, et al. Antinociceptive Effect of Butea Monosperma On Vincristine-induced Neuropathic Pain Model in Rats. Toxicol Ind Health. 2013;29(1):3-13. PubMed PMID: 22287618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats. AU - Thiagarajan,Venkata Rathina Kumar, AU - Shanmugam,Palanichamy, AU - Krishnan,Uma Maheswari, AU - Muthuraman,Arunachalam, AU - Singh,Nirmal, Y1 - 2012/01/27/ PY - 2012/1/31/entrez PY - 2012/1/31/pubmed PY - 2013/7/10/medline SP - 3 EP - 13 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 29 IS - 1 N2 - Neuropathic pain is a chronic neurodegenerative disease. It is well characterized by spontaneous pain, hyperalgesia, hypothesia, dysesthesia and allodynia. The present study was designed to investigate the antinociceptive potential of Butea monosperma on vincristine-induced painful neuropathy in rats. Vincristine was administered for induction of neuropathic pain in experimental animals. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia and allodynia in the hind paw and tail thermal hyperalgesia, respectively, as an index of peripheral and central pain sensation. Tissue thiobarbituric acid reactive substances (TBARSs), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Microscopically, histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of B. monosperma leaves and pregabalin were administered for 14 consecutive days. Vincristine administration resulted in significant reduction in behavioural (i.e. hyperalgesia and allodynic pain sensation) changes along with a rise in the levels of TBARS, total calcium and decrease in GSH levels when compared with the normal control group. Moreover, significant histological changes were also observed. Pretreatment with B. monosperma significantly attenuated vincristine-induced development of painful behavioural, biochemical and histological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. B. monosperma ameliorated vincristine-induced painful neuropathy. It may be due to its potential of antioxidative, neuroprotective and calcium channel inactivation. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/22287618/Antinociceptive_effect_of_Butea_monosperma_on_vincristine_induced_neuropathic_pain_model_in_rats_ L2 - https://journals.sagepub.com/doi/10.1177/0748233711432573?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -