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Pentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigs.
Hear Res. 1990 Aug 01; 47(1-2):169-74.HR

Abstract

The effects of pentoxifylline on cochlear blood flow (CoBF) were investigated in anesthetized guinea pigs by laser Doppler flowmetry and intravital microscopy red blood cell velocity measurement. Intra-arterial infusion of pentoxifylline (3, 4, and 5 mg/kg/min) produced dose-dependent reductions in blood pressure, accompanied by significant elevations in CoBF that were not dose-dependent. These results are in general agreement with previous findings from our laboratory utilizing normotensive and spontaneously hypertensive rats, however, in contrast with rats, guinea pigs revealed an initial decrease in CoBF followed by an increase. Also, pentoxifylline produced relatively smaller elevations in CoBF in guinea pigs as compared with those previously reported in rats. Taken together these results support the hypothesis that pentoxifylline increases vascular perfusion by decreasing blood viscosity and increasing the plasticity of red blood cells.

Authors+Show Affiliations

Department of Psychology, Washington State University, Pullman 99164-4820.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2228793

Citation

Coleman, J K., et al. "Pentoxifylline Increases Cochlear Blood Flow While Decreasing Blood Pressure in Guinea Pigs." Hearing Research, vol. 47, no. 1-2, 1990, pp. 169-74.
Coleman JK, Quirk WS, Dengerink HA, et al. Pentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigs. Hear Res. 1990;47(1-2):169-74.
Coleman, J. K., Quirk, W. S., Dengerink, H. A., & Wright, J. W. (1990). Pentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigs. Hearing Research, 47(1-2), 169-74.
Coleman JK, et al. Pentoxifylline Increases Cochlear Blood Flow While Decreasing Blood Pressure in Guinea Pigs. Hear Res. 1990 Aug 1;47(1-2):169-74. PubMed PMID: 2228793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigs. AU - Coleman,J K, AU - Quirk,W S, AU - Dengerink,H A, AU - Wright,J W, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 169 EP - 74 JF - Hearing research JO - Hear. Res. VL - 47 IS - 1-2 N2 - The effects of pentoxifylline on cochlear blood flow (CoBF) were investigated in anesthetized guinea pigs by laser Doppler flowmetry and intravital microscopy red blood cell velocity measurement. Intra-arterial infusion of pentoxifylline (3, 4, and 5 mg/kg/min) produced dose-dependent reductions in blood pressure, accompanied by significant elevations in CoBF that were not dose-dependent. These results are in general agreement with previous findings from our laboratory utilizing normotensive and spontaneously hypertensive rats, however, in contrast with rats, guinea pigs revealed an initial decrease in CoBF followed by an increase. Also, pentoxifylline produced relatively smaller elevations in CoBF in guinea pigs as compared with those previously reported in rats. Taken together these results support the hypothesis that pentoxifylline increases vascular perfusion by decreasing blood viscosity and increasing the plasticity of red blood cells. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/2228793/Pentoxifylline_increases_cochlear_blood_flow_while_decreasing_blood_pressure_in_guinea_pigs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(90)90174-N DB - PRIME DP - Unbound Medicine ER -