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Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men.
Br J Nutr. 2012 Sep 28; 108(6):958-62.BJ

Abstract

We aimed to determine the effect of consuming pure isolated micellar casein or pure whey protein isolate on rates of myofibrillar protein synthesis (MPS) at rest and after resistance exercise in elderly men. Healthy elderly men (72 (sem 1) years; BMI 26·4 (sem 0·7) kg/m²) were divided into two groups (n 7 each) who received a primed, constant infusion of l-[ring-¹³C₆]phenylalanine to measure MPS at rest and during 4 h of exercise recovery. Participants performed unilateral leg resistance exercise followed by the consumption of isonitrogenous quantities (20 g) of casein or whey. Blood essential amino acids and leucine concentration peaked 60 min post-drink and were greater in amplitude after whey protein ingestion (both, P < 0·05). MPS in the rested leg was 65 % higher (P = 0·002) after ingestion of whey (0·040 (sem 0·003) %/h) when compared with micellar casein (0·024 (sem 0·002) %/h). Similarly, resistance exercise-stimulated rates of MPS were greater (P < 0·001) after whey ingestion (0·059 (sem 0·005) %/h) v. micellar casein (0·035 (sem 0·002) %/h). We conclude that ingestion of isolated whey protein supports greater rates of MPS than micellar casein both at rest and after resistance exercise in healthy elderly men. This result is probably related to a greater hyperaminoacidaemia or leucinaemia with whey ingestion.

Authors+Show Affiliations

Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22289570

Citation

Burd, Nicholas A., et al. "Greater Stimulation of Myofibrillar Protein Synthesis With Ingestion of Whey Protein Isolate V. Micellar Casein at Rest and After Resistance Exercise in Elderly Men." The British Journal of Nutrition, vol. 108, no. 6, 2012, pp. 958-62.
Burd NA, Yang Y, Moore DR, et al. Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men. Br J Nutr. 2012;108(6):958-62.
Burd, N. A., Yang, Y., Moore, D. R., Tang, J. E., Tarnopolsky, M. A., & Phillips, S. M. (2012). Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men. The British Journal of Nutrition, 108(6), 958-62. https://doi.org/10.1017/S0007114511006271
Burd NA, et al. Greater Stimulation of Myofibrillar Protein Synthesis With Ingestion of Whey Protein Isolate V. Micellar Casein at Rest and After Resistance Exercise in Elderly Men. Br J Nutr. 2012 Sep 28;108(6):958-62. PubMed PMID: 22289570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men. AU - Burd,Nicholas A, AU - Yang,Yifan, AU - Moore,Daniel R, AU - Tang,Jason E, AU - Tarnopolsky,Mark A, AU - Phillips,Stuart M, Y1 - 2012/01/31/ PY - 2012/2/1/entrez PY - 2012/2/1/pubmed PY - 2012/12/10/medline SP - 958 EP - 62 JF - The British journal of nutrition JO - Br J Nutr VL - 108 IS - 6 N2 - We aimed to determine the effect of consuming pure isolated micellar casein or pure whey protein isolate on rates of myofibrillar protein synthesis (MPS) at rest and after resistance exercise in elderly men. Healthy elderly men (72 (sem 1) years; BMI 26·4 (sem 0·7) kg/m²) were divided into two groups (n 7 each) who received a primed, constant infusion of l-[ring-¹³C₆]phenylalanine to measure MPS at rest and during 4 h of exercise recovery. Participants performed unilateral leg resistance exercise followed by the consumption of isonitrogenous quantities (20 g) of casein or whey. Blood essential amino acids and leucine concentration peaked 60 min post-drink and were greater in amplitude after whey protein ingestion (both, P < 0·05). MPS in the rested leg was 65 % higher (P = 0·002) after ingestion of whey (0·040 (sem 0·003) %/h) when compared with micellar casein (0·024 (sem 0·002) %/h). Similarly, resistance exercise-stimulated rates of MPS were greater (P < 0·001) after whey ingestion (0·059 (sem 0·005) %/h) v. micellar casein (0·035 (sem 0·002) %/h). We conclude that ingestion of isolated whey protein supports greater rates of MPS than micellar casein both at rest and after resistance exercise in healthy elderly men. This result is probably related to a greater hyperaminoacidaemia or leucinaemia with whey ingestion. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/22289570/Greater_stimulation_of_myofibrillar_protein_synthesis_with_ingestion_of_whey_protein_isolate_v__micellar_casein_at_rest_and_after_resistance_exercise_in_elderly_men_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511006271/type/journal_article DB - PRIME DP - Unbound Medicine ER -