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Poor bone microarchitecture in older men with impaired physical performance--the STRAMBO study.
Osteoporos Int 2012; 23(12):2785-96OI

Abstract

In 810 men ≥ 60 years, poor physical performance of lower limbs was associated with lower areal bone mineral density (aBMD) of total hip and poor bone microarchitecture at the distal tibia (assessed by HR-pQCT). Men who reported falls had lower hip aBMD and lower cortical density at the distal tibia.

INTRODUCTION

The aim of this study was to assess the association between bone microarchitecture and physical performance in older men.

METHODS

Volumetric bone mineral density (vBMD) and bone microarchitecture were assessed in 810 men ≥ 60 years at the distal radius and tibia by high resolution pQCT. aBMD was measured at the spine, hip, whole body, and distal radius by dual energy X-ray absorptiometry. Clinical tests included chair stands and tests of static and dynamic balance. We calculated a composite score summarizing abilities and time required to perform the tests.

RESULTS

In multivariable models, men who failed in ≥ one test had lower total hip aBMD than men who accomplished all the tests. They had lower total vBMD (Tt.vBMD), cortical thickness (Ct.Th), trabecular vBMD (Tb.vBMD), and more heterogenous trabecular distribution (Tb.Sp.SD) at the distal tibia (p < 0.05). Men who failed in ≥ two tests had lower aBMD at the total hip, femoral neck, and trochanter as well as lower Tt.vBMD, cortical vBMD (Ct.vBMD), Ct.Th and trabecular number (Tb.N), and higher Tb.Sp.SD at the distal tibia (p < 0.05). Men in the lowest quartile of the composite score had lower aBMD (total hip, distal radius), lower Tb.vBMD and Tb.N at the distal radius, and lower Tt.vBMD, Ct.vBMD, Ct.Th, Tb.vBMD, and Tb.N, and higher Tb.Sp.SD at the distal tibia compared with the highest quartile. In multivariables models, men reporting falls had lower total hip aBMD and lower distal tibia Ct.vBMD (p < 0.01).

CONCLUSION

In older men, poor physical performance is associated with lower hip aBMD and poor bone microarchitecture (mainly at the distal tibia).

Authors+Show Affiliations

INSERM UMR 1033, Université de Lyon, Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22290241

Citation

Blaizot, S, et al. "Poor Bone Microarchitecture in Older Men With Impaired Physical Performance--the STRAMBO Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 23, no. 12, 2012, pp. 2785-96.
Blaizot S, Boutroy S, Vilayphiou N, et al. Poor bone microarchitecture in older men with impaired physical performance--the STRAMBO study. Osteoporos Int. 2012;23(12):2785-96.
Blaizot, S., Boutroy, S., Vilayphiou, N., Boonen, S., Chapurlat, R., & Szulc, P. (2012). Poor bone microarchitecture in older men with impaired physical performance--the STRAMBO study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 23(12), pp. 2785-96.
Blaizot S, et al. Poor Bone Microarchitecture in Older Men With Impaired Physical Performance--the STRAMBO Study. Osteoporos Int. 2012;23(12):2785-96. PubMed PMID: 22290241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poor bone microarchitecture in older men with impaired physical performance--the STRAMBO study. AU - Blaizot,S, AU - Boutroy,S, AU - Vilayphiou,N, AU - Boonen,S, AU - Chapurlat,R, AU - Szulc,P, PY - 2011/08/26/received PY - 2012/01/09/accepted PY - 2012/2/1/entrez PY - 2012/2/1/pubmed PY - 2013/6/12/medline SP - 2785 EP - 96 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 23 IS - 12 N2 - UNLABELLED: In 810 men ≥ 60 years, poor physical performance of lower limbs was associated with lower areal bone mineral density (aBMD) of total hip and poor bone microarchitecture at the distal tibia (assessed by HR-pQCT). Men who reported falls had lower hip aBMD and lower cortical density at the distal tibia. INTRODUCTION: The aim of this study was to assess the association between bone microarchitecture and physical performance in older men. METHODS: Volumetric bone mineral density (vBMD) and bone microarchitecture were assessed in 810 men ≥ 60 years at the distal radius and tibia by high resolution pQCT. aBMD was measured at the spine, hip, whole body, and distal radius by dual energy X-ray absorptiometry. Clinical tests included chair stands and tests of static and dynamic balance. We calculated a composite score summarizing abilities and time required to perform the tests. RESULTS: In multivariable models, men who failed in ≥ one test had lower total hip aBMD than men who accomplished all the tests. They had lower total vBMD (Tt.vBMD), cortical thickness (Ct.Th), trabecular vBMD (Tb.vBMD), and more heterogenous trabecular distribution (Tb.Sp.SD) at the distal tibia (p < 0.05). Men who failed in ≥ two tests had lower aBMD at the total hip, femoral neck, and trochanter as well as lower Tt.vBMD, cortical vBMD (Ct.vBMD), Ct.Th and trabecular number (Tb.N), and higher Tb.Sp.SD at the distal tibia (p < 0.05). Men in the lowest quartile of the composite score had lower aBMD (total hip, distal radius), lower Tb.vBMD and Tb.N at the distal radius, and lower Tt.vBMD, Ct.vBMD, Ct.Th, Tb.vBMD, and Tb.N, and higher Tb.Sp.SD at the distal tibia compared with the highest quartile. In multivariables models, men reporting falls had lower total hip aBMD and lower distal tibia Ct.vBMD (p < 0.01). CONCLUSION: In older men, poor physical performance is associated with lower hip aBMD and poor bone microarchitecture (mainly at the distal tibia). SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/22290241/Poor_bone_microarchitecture_in_older_men_with_impaired_physical_performance__the_STRAMBO_study_ L2 - https://dx.doi.org/10.1007/s00198-012-1906-0 DB - PRIME DP - Unbound Medicine ER -