Tags

Type your tag names separated by a space and hit enter

Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia.
Am J Hematol. 2012 Apr; 87(4):349-53.AJ

Abstract

Disease relapse still greatly interferes with the success of allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL). This study retrospectively evaluated the long-term safety and efficacy of a conditioning regimen consisting of total body irradiation (TBI; 12 Gy), cyclophosphamide (CY; 60 mg kg(-1) , two doses), and high-dose cytarabine (Ara-C; 2 g m(-2) ; four doses) for patients with ALL. Fifty-five patients (median age: 31-years old) were evaluated. Stem cells were from human leukocyte antigen-identical siblings in 22 patients and from alternative donors in 33. There were no cases of early death before engraftment, and 100-day transplant-related mortality was 7.3%. With a median follow-up period of 9.6 years, 5-year overall and disease-free survival were 63.2% (95% CI: 46.5-79.9%) and 63.6% (95% CI: 47.1-80.1%) in patients with complete remission, respectively, both of which were significantly higher than the values of 27.3% (95% CI: 8.7-46.0%) and 22.7% (95% CI: 5.3-40.1%) for patients in advanced stages (P < 0.01). These results suggest that TBI and CY (TBI-CY) plus Ara-C could be a feasible and effective conditioning regimen for adult patients with ALL both in remission and in advanced stages, and a future study to compare this combination therapy with TBI-CY is required.

Authors+Show Affiliations

Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. tmori@a3.keio.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

22290459

Citation

Mori, Takehiko, et al. "Safety and Efficacy of Total Body Irradiation, Cyclophosphamide, and Cytarabine as a Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Acute Lymphoblastic Leukemia." American Journal of Hematology, vol. 87, no. 4, 2012, pp. 349-53.
Mori T, Aisa Y, Kato J, et al. Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia. Am J Hematol. 2012;87(4):349-53.
Mori, T., Aisa, Y., Kato, J., Yamane, A., Nakazato, T., Shigematsu, N., & Okamoto, S. (2012). Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia. American Journal of Hematology, 87(4), 349-53. https://doi.org/10.1002/ajh.23109
Mori T, et al. Safety and Efficacy of Total Body Irradiation, Cyclophosphamide, and Cytarabine as a Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Acute Lymphoblastic Leukemia. Am J Hematol. 2012;87(4):349-53. PubMed PMID: 22290459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and efficacy of total body irradiation, cyclophosphamide, and cytarabine as a conditioning regimen for allogeneic hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia. AU - Mori,Takehiko, AU - Aisa,Yoshinobu, AU - Kato,Jun, AU - Yamane,Akiko, AU - Nakazato,Tomonori, AU - Shigematsu,Naoyuki, AU - Okamoto,Shinichiro, Y1 - 2012/01/31/ PY - 2011/09/21/received PY - 2011/11/16/revised PY - 2011/12/19/accepted PY - 2012/2/1/entrez PY - 2012/2/1/pubmed PY - 2012/5/30/medline SP - 349 EP - 53 JF - American journal of hematology JO - Am J Hematol VL - 87 IS - 4 N2 - Disease relapse still greatly interferes with the success of allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL). This study retrospectively evaluated the long-term safety and efficacy of a conditioning regimen consisting of total body irradiation (TBI; 12 Gy), cyclophosphamide (CY; 60 mg kg(-1) , two doses), and high-dose cytarabine (Ara-C; 2 g m(-2) ; four doses) for patients with ALL. Fifty-five patients (median age: 31-years old) were evaluated. Stem cells were from human leukocyte antigen-identical siblings in 22 patients and from alternative donors in 33. There were no cases of early death before engraftment, and 100-day transplant-related mortality was 7.3%. With a median follow-up period of 9.6 years, 5-year overall and disease-free survival were 63.2% (95% CI: 46.5-79.9%) and 63.6% (95% CI: 47.1-80.1%) in patients with complete remission, respectively, both of which were significantly higher than the values of 27.3% (95% CI: 8.7-46.0%) and 22.7% (95% CI: 5.3-40.1%) for patients in advanced stages (P < 0.01). These results suggest that TBI and CY (TBI-CY) plus Ara-C could be a feasible and effective conditioning regimen for adult patients with ALL both in remission and in advanced stages, and a future study to compare this combination therapy with TBI-CY is required. SN - 1096-8652 UR - https://www.unboundmedicine.com/medline/citation/22290459/Safety_and_efficacy_of_total_body_irradiation_cyclophosphamide_and_cytarabine_as_a_conditioning_regimen_for_allogeneic_hematopoietic_stem_cell_transplantation_in_patients_with_acute_lymphoblastic_leukemia_ L2 - https://doi.org/10.1002/ajh.23109 DB - PRIME DP - Unbound Medicine ER -