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Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer.
Asian Pac J Cancer Prev 2011; 12(8):2019-23AP

Abstract

AIM

Genetic and environmental factors may play roles in the pathogenesis of esophageal cancer and susceptibility may be modified by functional polymorphisms in folate metabolic genes, such as methylenetetrahydrofolate reductase (MTHFR). We here evaluated associations of the MTHFR C677T polymorphism and folate intake with esophageal cancer.

METHODS

A matched hospital-based case-control study with 155 esophageal cancer and 310 non-cancer controls was conducted in Southern of China with gene-environment interactions evaluated between the MTHFR C667T polymorphism and drinking and smoking, as well as folate intake.

RESULTS

Individuals carrying MTHFR 667CT [adjusted odds ratio (OR), 1.95; 95% confidence interval (CI), 1.23-2.62] and TT [adjusted odds ratio (OR), 3.36; 95% confidence interval (CI), 1.46-8.74] had significantly increased esophageal cancer risk compared with those with MTHFR 667CC genotype. Folate intake was seen to have non-significant preventive effect. In former, moderate and heavy drinkers, a high esophageal cancer risk was observed for those with an MTHFR 677T allele genotype [ORs: 5.0(1.29-18.88), 3.70(1.83-7.66) and 5.77(2.11-15.72), respectively]. Significant interaction was found for moderate-heavy drinking and the MTHFR 677T allele genotype for esophageal cancer risk (p<0.05). Significant increased risk was also found in moderate and heavy smokers with the two genotypes [ORs: 3.58(1.64-7.80) and 4.51(1.15-17.78), respectively]. High folate intake and MTHFR 677TT was associated with a non-significant tendency for decreased esophageal cancer risk.

CONCLUSION

Our finding supports the hypothesis that MTHFR C667T polymorphisms play a role in pathogenesis of esophageal cancer in the Chinese population.

Authors+Show Affiliations

Dept of Anesthesiology, China-Japan Union Hospital, Jilin University, Jilin, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22292644

Citation

Zhao, Pengcheng, et al. "Folate Intake, Methylenetetrahydrofolate Reductase Polymorphisms, and Risk of Esophageal Cancer." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 12, no. 8, 2011, pp. 2019-23.
Zhao P, Lin F, Li Z, et al. Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. Asian Pac J Cancer Prev. 2011;12(8):2019-23.
Zhao, P., Lin, F., Li, Z., Lin, B., Lin, J., & Luo, R. (2011). Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. Asian Pacific Journal of Cancer Prevention : APJCP, 12(8), pp. 2019-23.
Zhao P, et al. Folate Intake, Methylenetetrahydrofolate Reductase Polymorphisms, and Risk of Esophageal Cancer. Asian Pac J Cancer Prev. 2011;12(8):2019-23. PubMed PMID: 22292644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. AU - Zhao,Pengcheng, AU - Lin,Fengsong, AU - Li,Zhe, AU - Lin,Baisong, AU - Lin,Jing, AU - Luo,Rongcheng, PY - 2012/2/2/entrez PY - 2012/2/2/pubmed PY - 2012/8/28/medline SP - 2019 EP - 23 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 12 IS - 8 N2 - AIM: Genetic and environmental factors may play roles in the pathogenesis of esophageal cancer and susceptibility may be modified by functional polymorphisms in folate metabolic genes, such as methylenetetrahydrofolate reductase (MTHFR). We here evaluated associations of the MTHFR C677T polymorphism and folate intake with esophageal cancer. METHODS: A matched hospital-based case-control study with 155 esophageal cancer and 310 non-cancer controls was conducted in Southern of China with gene-environment interactions evaluated between the MTHFR C667T polymorphism and drinking and smoking, as well as folate intake. RESULTS: Individuals carrying MTHFR 667CT [adjusted odds ratio (OR), 1.95; 95% confidence interval (CI), 1.23-2.62] and TT [adjusted odds ratio (OR), 3.36; 95% confidence interval (CI), 1.46-8.74] had significantly increased esophageal cancer risk compared with those with MTHFR 667CC genotype. Folate intake was seen to have non-significant preventive effect. In former, moderate and heavy drinkers, a high esophageal cancer risk was observed for those with an MTHFR 677T allele genotype [ORs: 5.0(1.29-18.88), 3.70(1.83-7.66) and 5.77(2.11-15.72), respectively]. Significant interaction was found for moderate-heavy drinking and the MTHFR 677T allele genotype for esophageal cancer risk (p<0.05). Significant increased risk was also found in moderate and heavy smokers with the two genotypes [ORs: 3.58(1.64-7.80) and 4.51(1.15-17.78), respectively]. High folate intake and MTHFR 677TT was associated with a non-significant tendency for decreased esophageal cancer risk. CONCLUSION: Our finding supports the hypothesis that MTHFR C667T polymorphisms play a role in pathogenesis of esophageal cancer in the Chinese population. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/22292644/Folate_intake_methylenetetrahydrofolate_reductase_polymorphisms_and_risk_of_esophageal_cancer_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&amp;id=pmid:22292644&amp;key=2011.12.8.2019 DB - PRIME DP - Unbound Medicine ER -