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Serum uric acid as a marker of all-cause mortality in an elderly patient cohort.
Nefrologia. 2012; 32(1):67-72.N

Abstract

INTRODUCTION

There is growing evidence of the role of serum uric acid (SUA) as a risk factor for cardiovascular and renal disease. We analysed the association between baseline SUA and overall mortality in a cohort of elderly patients followed prospectively for 5 years.

PATIENTS AND METHODS

Eighty clinically stable patients, median age 83 years (range 69-97), 31.3% men, 35% diabetics, 83% hypertensives were randomly recruited at Geriatrics and Nephrology visits between January and April 2006 and followed for 5 years. We measured baseline SUA and serum creatinine and estimated glomerular filtration rate (GFR) with MDRD abbreviated. In Nephrology Department patients, we measured proteinuria in 24-hour urine and in Geriatrics department patients we measured proteinuria (mg/dl)/creatinine (mg/dl) in urine (first morning urine). Predictive variables were: baseline SUA and plasma creatinine; estimated GFR (abbreviated MDRD formula); and we recorded age, gender, baseline comorbidity (Charlson index), individualised cardiovascular treatment and mortality.

STATISTICAL ANALYSIS

SPSS15.0.

RESULTS

baseline SUA was normally distributed and its median was 5.85 mg/dl. We found no significant differences in levels of SUA by gender, history of diabetes mellitus, hypertension, diuretic drug use, heart disease, peripheral arterial disease or stroke. Patients with a history of heart failure had significantly higher SUA (7.00 ± 1.74 vs 5.90 ± 1.71, P=.031). Some 41 deaths occurred during follow-up (15 men and 26 women): 15 due to general deterioration, 8 due to infections, 4 due to stroke, 4 due to tumours, 3 due to cardiovascular disease, 2 due to complications of fractures and 5 due to unknown causes. Patients with SUA higher than the median had significantly lower GFR and higher mortality at 5 years. In the Cox analysis for overall mortality [independent variables: age, gender, Charlson Index, history of heart failure, SUA, creatinine, proteinuria and GFR (MDRD)] only SUA levels (HR: 1.35; 1.17-1.56 P=.000) were independently associated with mortality.

CONCLUSIONS

In our study, levels of SUA are an independent risk factor for mortality in elderly patients.

Authors+Show Affiliations

Nephrology Department, General Hospital of Segovia, Segovia, Spain. mherasb@saludcastillayleon.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

22294005

Citation

Heras, Manuel, et al. "Serum Uric Acid as a Marker of All-cause Mortality in an Elderly Patient Cohort." Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia, vol. 32, no. 1, 2012, pp. 67-72.
Heras M, Fernández-Reyes MJ, Sánchez R, et al. Serum uric acid as a marker of all-cause mortality in an elderly patient cohort. Nefrologia. 2012;32(1):67-72.
Heras, M., Fernández-Reyes, M. J., Sánchez, R., Molina, Á., Rodríguez, A., & Álvarez-Ude, F. (2012). Serum uric acid as a marker of all-cause mortality in an elderly patient cohort. Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia, 32(1), 67-72. https://doi.org/10.3265/Nefrologia.pre2011.Nov.11021
Heras M, et al. Serum Uric Acid as a Marker of All-cause Mortality in an Elderly Patient Cohort. Nefrologia. 2012;32(1):67-72. PubMed PMID: 22294005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid as a marker of all-cause mortality in an elderly patient cohort. AU - Heras,Manuel, AU - Fernández-Reyes,María J, AU - Sánchez,Rosa, AU - Molina,Álvaro, AU - Rodríguez,Astrid, AU - Álvarez-Ude,Fernando, PY - 2011/11/01/accepted PY - 2012/2/2/entrez PY - 2012/2/2/pubmed PY - 2012/5/30/medline SP - 67 EP - 72 JF - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia JO - Nefrologia VL - 32 IS - 1 N2 - INTRODUCTION: There is growing evidence of the role of serum uric acid (SUA) as a risk factor for cardiovascular and renal disease. We analysed the association between baseline SUA and overall mortality in a cohort of elderly patients followed prospectively for 5 years. PATIENTS AND METHODS: Eighty clinically stable patients, median age 83 years (range 69-97), 31.3% men, 35% diabetics, 83% hypertensives were randomly recruited at Geriatrics and Nephrology visits between January and April 2006 and followed for 5 years. We measured baseline SUA and serum creatinine and estimated glomerular filtration rate (GFR) with MDRD abbreviated. In Nephrology Department patients, we measured proteinuria in 24-hour urine and in Geriatrics department patients we measured proteinuria (mg/dl)/creatinine (mg/dl) in urine (first morning urine). Predictive variables were: baseline SUA and plasma creatinine; estimated GFR (abbreviated MDRD formula); and we recorded age, gender, baseline comorbidity (Charlson index), individualised cardiovascular treatment and mortality. STATISTICAL ANALYSIS: SPSS15.0. RESULTS: baseline SUA was normally distributed and its median was 5.85 mg/dl. We found no significant differences in levels of SUA by gender, history of diabetes mellitus, hypertension, diuretic drug use, heart disease, peripheral arterial disease or stroke. Patients with a history of heart failure had significantly higher SUA (7.00 ± 1.74 vs 5.90 ± 1.71, P=.031). Some 41 deaths occurred during follow-up (15 men and 26 women): 15 due to general deterioration, 8 due to infections, 4 due to stroke, 4 due to tumours, 3 due to cardiovascular disease, 2 due to complications of fractures and 5 due to unknown causes. Patients with SUA higher than the median had significantly lower GFR and higher mortality at 5 years. In the Cox analysis for overall mortality [independent variables: age, gender, Charlson Index, history of heart failure, SUA, creatinine, proteinuria and GFR (MDRD)] only SUA levels (HR: 1.35; 1.17-1.56 P=.000) were independently associated with mortality. CONCLUSIONS: In our study, levels of SUA are an independent risk factor for mortality in elderly patients. SN - 1989-2284 UR - https://www.unboundmedicine.com/medline/citation/22294005/Serum_uric_acid_as_a_marker_of_all_cause_mortality_in_an_elderly_patient_cohort_ L2 - http://www.revistanefrologia.com/es/linksolver/ft/ivp/0211-6995/32/67 DB - PRIME DP - Unbound Medicine ER -