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Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species.
Phytother Res 2012; 26(9):1371-4PR

Abstract

Biofilm producing bacteria such as Staphylococcus species and Escherichia coli are the most common cause of catheter related urinary tract infections (UTIs). The American cranberry (Vaccinium macrocarpon) is utilized widely as a prophylaxis for UTIs due to its prevention of microbial adhesion. Cranberry contains proanthocyanidins (PACs), which have been implicated as active constituents responsible for its bacterial antiadhesive properties. Despite overwhelming data supporting cranberry's beneficial effects against human pathogenic bacteria, there is limited information regarding its effects on biofilm formation. This study evaluated the effects of three proprietary PAC-standardized cranberry extracts on the inhibition of bacterial growth and biofilm production against a panel of clinically relevant pathogens: Staphylococcus epidermidis, Staphylococcus aureus, clinical methicillin-resistant S. aureus (MRSA), Staphylococcus saprophyticus and Escherichia coli. The extracts inhibited the growth of the Gram-positive bacteria (Staphylococcus spp.) but not the Gram-negative species (E. coli) with minimum inhibitory concentrations in the range 0.02-5 mg/mL. The extracts also inhibited biofilm production by the Gram-positive bacteria but did not eradicate their established biofilm. These results suggest that cranberry may have beneficial effects against the growth and biofilm producing capability of Gram-positive bacteria pathogens.

Authors+Show Affiliations

Departments of Biomedical and Pharmaceutical Sciences and Pharmacy Practice, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22294419

Citation

LaPlante, Kerry L., et al. "Effects of Cranberry Extracts On Growth and Biofilm Production of Escherichia Coli and Staphylococcus Species." Phytotherapy Research : PTR, vol. 26, no. 9, 2012, pp. 1371-4.
LaPlante KL, Sarkisian SA, Woodmansee S, et al. Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species. Phytother Res. 2012;26(9):1371-4.
LaPlante, K. L., Sarkisian, S. A., Woodmansee, S., Rowley, D. C., & Seeram, N. P. (2012). Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species. Phytotherapy Research : PTR, 26(9), pp. 1371-4. doi:10.1002/ptr.4592.
LaPlante KL, et al. Effects of Cranberry Extracts On Growth and Biofilm Production of Escherichia Coli and Staphylococcus Species. Phytother Res. 2012;26(9):1371-4. PubMed PMID: 22294419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species. AU - LaPlante,Kerry L, AU - Sarkisian,Simon A, AU - Woodmansee,Suzanne, AU - Rowley,David C, AU - Seeram,Navindra P, Y1 - 2012/02/01/ PY - 2011/09/13/received PY - 2011/11/22/revised PY - 2011/11/26/accepted PY - 2012/2/2/entrez PY - 2012/2/2/pubmed PY - 2013/1/4/medline SP - 1371 EP - 4 JF - Phytotherapy research : PTR JO - Phytother Res VL - 26 IS - 9 N2 - Biofilm producing bacteria such as Staphylococcus species and Escherichia coli are the most common cause of catheter related urinary tract infections (UTIs). The American cranberry (Vaccinium macrocarpon) is utilized widely as a prophylaxis for UTIs due to its prevention of microbial adhesion. Cranberry contains proanthocyanidins (PACs), which have been implicated as active constituents responsible for its bacterial antiadhesive properties. Despite overwhelming data supporting cranberry's beneficial effects against human pathogenic bacteria, there is limited information regarding its effects on biofilm formation. This study evaluated the effects of three proprietary PAC-standardized cranberry extracts on the inhibition of bacterial growth and biofilm production against a panel of clinically relevant pathogens: Staphylococcus epidermidis, Staphylococcus aureus, clinical methicillin-resistant S. aureus (MRSA), Staphylococcus saprophyticus and Escherichia coli. The extracts inhibited the growth of the Gram-positive bacteria (Staphylococcus spp.) but not the Gram-negative species (E. coli) with minimum inhibitory concentrations in the range 0.02-5 mg/mL. The extracts also inhibited biofilm production by the Gram-positive bacteria but did not eradicate their established biofilm. These results suggest that cranberry may have beneficial effects against the growth and biofilm producing capability of Gram-positive bacteria pathogens. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/22294419/Effects_of_cranberry_extracts_on_growth_and_biofilm_production_of_Escherichia_coli_and_Staphylococcus_species_ L2 - https://doi.org/10.1002/ptr.4592 DB - PRIME DP - Unbound Medicine ER -