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An alternative approach to para-C-H arylation of phenol: palladium-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives.
Org Lett. 2012 Feb 17; 14(4):1172-5.OL

Abstract

An efficient approach to prepare para-aryl phenols has been developed by using a Pd-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives with aryl bromides. This approach provides various p-aryl phenols from the phenol surrogates, 2-cyclohexen-1-one derivatives, in a single reaction step on the basis of C-H arylation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Imahori T
Priority Organization for Innovation and Excellence, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555, Japan. imahori@kumamoto-u.ac.jp
Tokuda T
No affiliation info available
Taguchi T
No affiliation info available
Takahata H
No affiliation info available

MeSH

CatalysisCyclohexanonesMolecular StructurePalladiumPhenol

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22296212

Citation

Imahori, Tatsushi, et al. "An Alternative Approach to para-C-H Arylation of Phenol: Palladium-catalyzed Tandem Γ-arylation/aromatization of 2-cyclohexen-1-one Derivatives." Organic Letters, vol. 14, no. 4, 2012, pp. 1172-5.
Imahori T, Tokuda T, Taguchi T, et al. An alternative approach to para-C-H arylation of phenol: palladium-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives. Org Lett. 2012;14(4):1172-5.
Imahori, T., Tokuda, T., Taguchi, T., & Takahata, H. (2012). An alternative approach to para-C-H arylation of phenol: palladium-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives. Organic Letters, 14(4), 1172-5. https://doi.org/10.1021/ol300145g
Imahori T, et al. An Alternative Approach to para-C-H Arylation of Phenol: Palladium-catalyzed Tandem Γ-arylation/aromatization of 2-cyclohexen-1-one Derivatives. Org Lett. 2012 Feb 17;14(4):1172-5. PubMed PMID: 22296212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An alternative approach to para-C-H arylation of phenol: palladium-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives. AU - Imahori,Tatsushi, AU - Tokuda,Toru, AU - Taguchi,Tatsuya, AU - Takahata,Hiroki, Y1 - 2012/02/01/ PY - 2012/2/3/entrez PY - 2012/2/3/pubmed PY - 2012/5/16/medline SP - 1172 EP - 5 JF - Organic letters JO - Org Lett VL - 14 IS - 4 N2 - An efficient approach to prepare para-aryl phenols has been developed by using a Pd-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives with aryl bromides. This approach provides various p-aryl phenols from the phenol surrogates, 2-cyclohexen-1-one derivatives, in a single reaction step on the basis of C-H arylation. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/22296212/An_alternative_approach_to_para_C_H_arylation_of_phenol:_palladium_catalyzed_tandem_γ_arylation/aromatization_of_2_cyclohexen_1_one_derivatives_ L2 - https://doi.org/10.1021/ol300145g DB - PRIME DP - Unbound Medicine ER -