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Fat intake and its relationship with pre- and post-menopausal breast cancer risk: a case-control study in Malaysia.

Abstract

BACKGROUND

Fat intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent.

OBJECTIVE

To assess the association of premenopausal and postmenopausal breast cancer risk with fat and fat subtypes intake.

METHODOLOGY

This is a population based case-control study conducted in Kuala Lumpur, Malaysia from January 2006 to December 2007. Food intake pattern was collected from 382 breast cancer patients and 382 control group via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders was included in analysis.

RESULTS

This study showed that both premenopausal and postmenopausal breast cancer risk did not increase significantly with greater intake of total fat [quartile (Q) 4 versus Q1 OR=0.76, 95% CI, 0.23-2.45 and OR=1.36, 95% CI, 0.30-3.12], saturated fat (ORQ4 to Q1=1.43, 95% CI, 0.51-3.98 and ORQ4 to Q1=1.75, 95% CI, 0.62-3.40), monounsaturated fat (ORQ4 to Q1=0.96, 95% CI, 0.34-1.72 and ORQ4 to Q1=1.74, 95% CI, 0.22-2.79), polyunsaturated fat (ORQ4 to Q1=0.64, 95% CI, 0.23-1.73 and ORQ4 to Q1=0.74, 95% CI, 0.39-1.81), n-3 polyunsaturated fat (ORQ4 to Q1=1.10, 95% CI, 0.49-2.48 and ORQ4 to Q1=0.78, 95% CI, 0.28-2.18), n-6 polyunsaturated fat (ORQ4 to Q1=0.67, 95% CI, 0.24-1.84 and ORQ4 to Q1=0.71, 95% CI, 0.29-1.04) or energy intake (ORQ4 to Q1=1.52, 95% CI, 0.68-3.38 and ORQ4 to Q1=2.21, 95% CI, 0.93-3.36).

CONCLUSION

Total fat and fat subtypes were not associated with pre- and postmenopausal breast cancer risk after controlling for age, other breast cancer risk factors and energy intake. Despite the lack of association, the effects of total fat and fat subtypes intake during premenopausal years towards postmenopausal breast cancer risk still warrant investigation.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition and Dietetics, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Malaysia. suhaina@medic.ukm.my

    , , , , ,

    Source

    MeSH

    Breast Neoplasms
    Case-Control Studies
    Confidence Intervals
    Dietary Fats
    Eating
    Energy Intake
    Female
    Humans
    Logistic Models
    Malaysia
    Middle Aged
    Odds Ratio
    Postmenopause
    Premenopause
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22296351

    Citation

    Sulaiman, Suhaina, et al. "Fat Intake and Its Relationship With Pre- and Post-menopausal Breast Cancer Risk: a Case-control Study in Malaysia." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 12, no. 9, 2011, pp. 2167-78.
    Sulaiman S, Shahril MR, Shaharudin SH, et al. Fat intake and its relationship with pre- and post-menopausal breast cancer risk: a case-control study in Malaysia. Asian Pac J Cancer Prev. 2011;12(9):2167-78.
    Sulaiman, S., Shahril, M. R., Shaharudin, S. H., Emran, N. A., Muhammad, R., Ismail, F., & Husain, S. N. (2011). Fat intake and its relationship with pre- and post-menopausal breast cancer risk: a case-control study in Malaysia. Asian Pacific Journal of Cancer Prevention : APJCP, 12(9), pp. 2167-78.
    Sulaiman S, et al. Fat Intake and Its Relationship With Pre- and Post-menopausal Breast Cancer Risk: a Case-control Study in Malaysia. Asian Pac J Cancer Prev. 2011;12(9):2167-78. PubMed PMID: 22296351.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fat intake and its relationship with pre- and post-menopausal breast cancer risk: a case-control study in Malaysia. AU - Sulaiman,Suhaina, AU - Shahril,Mohd Razif, AU - Shaharudin,Soraya Hanie, AU - Emran,Nor Aina, AU - Muhammad,Rohaizak, AU - Ismail,Fuad, AU - Husain,Sharifah Noor Akmal Syed, PY - 2012/2/3/entrez PY - 2012/2/3/pubmed PY - 2012/9/19/medline SP - 2167 EP - 78 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 12 IS - 9 N2 - BACKGROUND: Fat intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent. OBJECTIVE: To assess the association of premenopausal and postmenopausal breast cancer risk with fat and fat subtypes intake. METHODOLOGY: This is a population based case-control study conducted in Kuala Lumpur, Malaysia from January 2006 to December 2007. Food intake pattern was collected from 382 breast cancer patients and 382 control group via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders was included in analysis. RESULTS: This study showed that both premenopausal and postmenopausal breast cancer risk did not increase significantly with greater intake of total fat [quartile (Q) 4 versus Q1 OR=0.76, 95% CI, 0.23-2.45 and OR=1.36, 95% CI, 0.30-3.12], saturated fat (ORQ4 to Q1=1.43, 95% CI, 0.51-3.98 and ORQ4 to Q1=1.75, 95% CI, 0.62-3.40), monounsaturated fat (ORQ4 to Q1=0.96, 95% CI, 0.34-1.72 and ORQ4 to Q1=1.74, 95% CI, 0.22-2.79), polyunsaturated fat (ORQ4 to Q1=0.64, 95% CI, 0.23-1.73 and ORQ4 to Q1=0.74, 95% CI, 0.39-1.81), n-3 polyunsaturated fat (ORQ4 to Q1=1.10, 95% CI, 0.49-2.48 and ORQ4 to Q1=0.78, 95% CI, 0.28-2.18), n-6 polyunsaturated fat (ORQ4 to Q1=0.67, 95% CI, 0.24-1.84 and ORQ4 to Q1=0.71, 95% CI, 0.29-1.04) or energy intake (ORQ4 to Q1=1.52, 95% CI, 0.68-3.38 and ORQ4 to Q1=2.21, 95% CI, 0.93-3.36). CONCLUSION: Total fat and fat subtypes were not associated with pre- and postmenopausal breast cancer risk after controlling for age, other breast cancer risk factors and energy intake. Despite the lack of association, the effects of total fat and fat subtypes intake during premenopausal years towards postmenopausal breast cancer risk still warrant investigation. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/22296351/Fat_intake_and_its_relationship_with_pre__and_post_menopausal_breast_cancer_risk:_a_case_control_study_in_Malaysia_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:22296351&key=2011.12.9.2167 DB - PRIME DP - Unbound Medicine ER -