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Impact of adrenal versus ovarian androgen ratio on signs and symptoms of polycystic ovarian syndrome.
Gynecol Endocrinol. 2012 Aug; 28(8):611-4.GE

Abstract

The aim of this study was to examine the effect of adrenal versus ovarian androgen (dehydroepiandrosterone sulfate/total testosterone [DHEAS/TT]) on clinical presentation and related metabolic disturbances in Turkish women with polycystic ovarian syndrome (PCOS). Two hundred eighty PCOS cases were taken into the study. For all cases, the DHEAS/TT ratio was calculated. The median value of this ratio was 4.40. Patients with an androgen ratio lower than 4.40 were included in Group 1 and cases with a ratio higher than 4.40 were Group 2. The two groups were compared in terms of hormonal, biochemical and clinical parameters. Body mass index and waist circumference were lower, the Ferriman-Gallwey score was higher and the cycle length was shorter in Group 2. High DHEAS level was associated with better lipid profiles and lower levels of inflammatory markers, meaning good metabolic control in these women, in spite of increased hirsutism rates. In patients with PCOS, both androgens are usually high in proportion to each other. Therefore, it would be more meaningful to use the DHEAS/TT ratio for an assessment of the metabolic and phenotypic effects of PCOS.

Authors+Show Affiliations

Department of Obstetrics & Gynecology, Fatih University, Faculty of Medicine, Ankara, Turkey. nerminkosus@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22296561

Citation

Köşüş, Nermin, et al. "Impact of Adrenal Versus Ovarian Androgen Ratio On Signs and Symptoms of Polycystic Ovarian Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 28, no. 8, 2012, pp. 611-4.
Köşüş N, Köşüş A, Kamalak Z, et al. Impact of adrenal versus ovarian androgen ratio on signs and symptoms of polycystic ovarian syndrome. Gynecol Endocrinol. 2012;28(8):611-4.
Köşüş, N., Köşüş, A., Kamalak, Z., Hızlı, D., & Turhan, N. Ö. (2012). Impact of adrenal versus ovarian androgen ratio on signs and symptoms of polycystic ovarian syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 28(8), 611-4. https://doi.org/10.3109/09513590.2011.650770
Köşüş N, et al. Impact of Adrenal Versus Ovarian Androgen Ratio On Signs and Symptoms of Polycystic Ovarian Syndrome. Gynecol Endocrinol. 2012;28(8):611-4. PubMed PMID: 22296561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of adrenal versus ovarian androgen ratio on signs and symptoms of polycystic ovarian syndrome. AU - Köşüş,Nermin, AU - Köşüş,Aydın, AU - Kamalak,Zeynep, AU - Hızlı,Deniz, AU - Turhan,Nilgün Ö, Y1 - 2012/02/01/ PY - 2012/2/3/entrez PY - 2012/2/3/pubmed PY - 2012/12/12/medline SP - 611 EP - 4 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 28 IS - 8 N2 - The aim of this study was to examine the effect of adrenal versus ovarian androgen (dehydroepiandrosterone sulfate/total testosterone [DHEAS/TT]) on clinical presentation and related metabolic disturbances in Turkish women with polycystic ovarian syndrome (PCOS). Two hundred eighty PCOS cases were taken into the study. For all cases, the DHEAS/TT ratio was calculated. The median value of this ratio was 4.40. Patients with an androgen ratio lower than 4.40 were included in Group 1 and cases with a ratio higher than 4.40 were Group 2. The two groups were compared in terms of hormonal, biochemical and clinical parameters. Body mass index and waist circumference were lower, the Ferriman-Gallwey score was higher and the cycle length was shorter in Group 2. High DHEAS level was associated with better lipid profiles and lower levels of inflammatory markers, meaning good metabolic control in these women, in spite of increased hirsutism rates. In patients with PCOS, both androgens are usually high in proportion to each other. Therefore, it would be more meaningful to use the DHEAS/TT ratio for an assessment of the metabolic and phenotypic effects of PCOS. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/22296561/Impact_of_adrenal_versus_ovarian_androgen_ratio_on_signs_and_symptoms_of_polycystic_ovarian_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513590.2011.650770 DB - PRIME DP - Unbound Medicine ER -