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Pacific region influenza surveillance for oseltamivir resistance.
J Clin Virol 2012; 54(1):73-5JC

Abstract

BACKGROUND

Hawaii and the United States-affiliated Pacific islands (USAPI) host over 8 million travelers annually, most of whom originate in Asia, Australia, and the Americas where prevalence of oseltamivir resistance in 2009 pandemic influenza A (H1N1) has been reported to be 2.5-3.5%.

OBJECTIVE

To survey a collection of samples from Hawaii and the USAPI that had tested positive for the 2009 pandemic influenza A (H1N1) virus by RTI-PCR to assess whether antiviral resistance emerged in these island communities during the 2009 H1N1 pandemic.

STUDY DESIGN

We examined RNA extracted from Hawaiian and USAPI cases for the neuraminidase H275Y mutation associated with oseltamivir resistance by pyrosequencing.

RESULTS

Two hundred and sixty-three (263) 2009 pandemic influenza A (H1N1) positive specimens were tested and 263/263 (100%) were shown to lack the mutation most commonly associated with oseltamivir resistance.

CONCLUSIONS

There was no evidence of oseltamivir resistant A(H1N1)pdm09 virus during the 2009 pandemic in the Pacific islands despite considerable travel exposure. Geographic isolation, the lack of a "second wave" of pandemic influenza, judicious antiviral use, aggressive vaccination, and below average tourism due to the global economic crisis may have been contributing factors. Continued surveillance and vigilance is necessary to monitor unpredictable influenza activity.

Authors+Show Affiliations

State Laboratories Division, Hawaii Department of Health, Pearl City, HI 96782, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22296793

Citation

Miller, Heather B., et al. "Pacific Region Influenza Surveillance for Oseltamivir Resistance." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 54, no. 1, 2012, pp. 73-5.
Miller HB, Gose RB, Nagata MT, et al. Pacific region influenza surveillance for oseltamivir resistance. J Clin Virol. 2012;54(1):73-5.
Miller, H. B., Gose, R. B., Nagata, M. T., Sciulli, R. H., & Whelen, A. C. (2012). Pacific region influenza surveillance for oseltamivir resistance. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 54(1), pp. 73-5. doi:10.1016/j.jcv.2012.01.007.
Miller HB, et al. Pacific Region Influenza Surveillance for Oseltamivir Resistance. J Clin Virol. 2012;54(1):73-5. PubMed PMID: 22296793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pacific region influenza surveillance for oseltamivir resistance. AU - Miller,Heather B, AU - Gose,Remedios B, AU - Nagata,Mark T, AU - Sciulli,Rebecca H, AU - Whelen,A Christian, Y1 - 2012/01/31/ PY - 2011/10/31/received PY - 2012/01/06/revised PY - 2012/01/09/accepted PY - 2012/2/3/entrez PY - 2012/2/3/pubmed PY - 2012/7/26/medline SP - 73 EP - 5 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J. Clin. Virol. VL - 54 IS - 1 N2 - BACKGROUND: Hawaii and the United States-affiliated Pacific islands (USAPI) host over 8 million travelers annually, most of whom originate in Asia, Australia, and the Americas where prevalence of oseltamivir resistance in 2009 pandemic influenza A (H1N1) has been reported to be 2.5-3.5%. OBJECTIVE: To survey a collection of samples from Hawaii and the USAPI that had tested positive for the 2009 pandemic influenza A (H1N1) virus by RTI-PCR to assess whether antiviral resistance emerged in these island communities during the 2009 H1N1 pandemic. STUDY DESIGN: We examined RNA extracted from Hawaiian and USAPI cases for the neuraminidase H275Y mutation associated with oseltamivir resistance by pyrosequencing. RESULTS: Two hundred and sixty-three (263) 2009 pandemic influenza A (H1N1) positive specimens were tested and 263/263 (100%) were shown to lack the mutation most commonly associated with oseltamivir resistance. CONCLUSIONS: There was no evidence of oseltamivir resistant A(H1N1)pdm09 virus during the 2009 pandemic in the Pacific islands despite considerable travel exposure. Geographic isolation, the lack of a "second wave" of pandemic influenza, judicious antiviral use, aggressive vaccination, and below average tourism due to the global economic crisis may have been contributing factors. Continued surveillance and vigilance is necessary to monitor unpredictable influenza activity. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/22296793/Pacific_region_influenza_surveillance_for_oseltamivir_resistance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(12)00012-1 DB - PRIME DP - Unbound Medicine ER -