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Changes over time in the relationship between symptoms of asthma, rhinoconjunctivitis and eczema: a global perspective from the International Study of Asthma and Allergies in Childhood (ISAAC).
Allergol Immunopathol (Madr) 2012 Sep-Oct; 40(5):267-74AI

Abstract

BACKGROUND

The International Study of Asthma and Allergies in Childhood (ISAAC) identified trends in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema over a seven-year period. We hypothesised that environmental influences on the three diseases are different and therefore investigated the correlation over time between trends in the prevalence of these diseases and their combinations at centre and individual level.

METHODS

Centre level analyses were correlations between time trends in the prevalence of symptoms. At an individual level, odds ratios were calculated for associations between symptoms between Phases One and Three. We also investigated potential effect modification in the younger versus older age group; male versus female; and by average Gross National Income per capita (GNI).

RESULTS

Both phases were completed in 66 centres in 37 countries for the 6-7 year age group and in 106 centres in 56 countries for the 13-14 year age group. We found that the correlations in time trends were stronger for the older age group than the younger one. Between symptoms of diseases, correlations of time trends were the strongest for rhinoconjunctivitis with eczema and weakest for eczema with asthma. The relationship between the three diseases was generally consistent over the seven-year period, and there was little association found with average GNI.

CONCLUSIONS

Despite some increase in the proportion of children with symptoms of asthma, rhinoconjunctivitis and eczema, the pattern between the three diseases has not changed much, suggesting that similar factors may be affecting them at a global level.

Authors+Show Affiliations

Department of Paediatrics, Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. mi.asher@auckland.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22297190

Citation

Asher, M I., et al. "Changes Over Time in the Relationship Between Symptoms of Asthma, Rhinoconjunctivitis and Eczema: a Global Perspective From the International Study of Asthma and Allergies in Childhood (ISAAC)." Allergologia Et Immunopathologia, vol. 40, no. 5, 2012, pp. 267-74.
Asher MI, Stewart AW, Wong G, et al. Changes over time in the relationship between symptoms of asthma, rhinoconjunctivitis and eczema: a global perspective from the International Study of Asthma and Allergies in Childhood (ISAAC). Allergol Immunopathol (Madr). 2012;40(5):267-74.
Asher, M. I., Stewart, A. W., Wong, G., Strachan, D. P., García-Marcos, L., & Anderson, H. R. (2012). Changes over time in the relationship between symptoms of asthma, rhinoconjunctivitis and eczema: a global perspective from the International Study of Asthma and Allergies in Childhood (ISAAC). Allergologia Et Immunopathologia, 40(5), pp. 267-74. doi:10.1016/j.aller.2011.11.004.
Asher MI, et al. Changes Over Time in the Relationship Between Symptoms of Asthma, Rhinoconjunctivitis and Eczema: a Global Perspective From the International Study of Asthma and Allergies in Childhood (ISAAC). Allergol Immunopathol (Madr). 2012;40(5):267-74. PubMed PMID: 22297190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes over time in the relationship between symptoms of asthma, rhinoconjunctivitis and eczema: a global perspective from the International Study of Asthma and Allergies in Childhood (ISAAC). AU - Asher,M I, AU - Stewart,A W, AU - Wong,G, AU - Strachan,D P, AU - García-Marcos,L, AU - Anderson,H R, AU - ,, Y1 - 2012/01/31/ PY - 2011/10/30/received PY - 2011/11/27/accepted PY - 2012/2/3/entrez PY - 2012/2/3/pubmed PY - 2013/3/2/medline SP - 267 EP - 74 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 40 IS - 5 N2 - BACKGROUND: The International Study of Asthma and Allergies in Childhood (ISAAC) identified trends in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema over a seven-year period. We hypothesised that environmental influences on the three diseases are different and therefore investigated the correlation over time between trends in the prevalence of these diseases and their combinations at centre and individual level. METHODS: Centre level analyses were correlations between time trends in the prevalence of symptoms. At an individual level, odds ratios were calculated for associations between symptoms between Phases One and Three. We also investigated potential effect modification in the younger versus older age group; male versus female; and by average Gross National Income per capita (GNI). RESULTS: Both phases were completed in 66 centres in 37 countries for the 6-7 year age group and in 106 centres in 56 countries for the 13-14 year age group. We found that the correlations in time trends were stronger for the older age group than the younger one. Between symptoms of diseases, correlations of time trends were the strongest for rhinoconjunctivitis with eczema and weakest for eczema with asthma. The relationship between the three diseases was generally consistent over the seven-year period, and there was little association found with average GNI. CONCLUSIONS: Despite some increase in the proportion of children with symptoms of asthma, rhinoconjunctivitis and eczema, the pattern between the three diseases has not changed much, suggesting that similar factors may be affecting them at a global level. SN - 1578-1267 UR - https://www.unboundmedicine.com/medline/citation/22297190/Changes_over_time_in_the_relationship_between_symptoms_of_asthma_rhinoconjunctivitis_and_eczema:_a_global_perspective_from_the_International_Study_of_Asthma_and_Allergies_in_Childhood__ISAAC__ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0301-0546(11)00363-6 DB - PRIME DP - Unbound Medicine ER -