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Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
J Neurol Sci. 2012 May 15; 316(1-2):116-21.JN

Abstract

BACKGROUND

Meta-analysis in European population found no association between rs12425791/rs11833579 and ischemic stroke. Several studies focused on East Asians have evaluated the association between this two SNPs and risk of ischemic stroke, but the results have been inconsistent. The aim of this study was to perform a meta-analysis to investigate a more authentic association between rs12425791 and rs11833579 G>A mutation and ischemic stroke in East Asian population, as well as in Chinese Han population.

METHODS

Systematic searches of electronic databases Embase, PubMed, Web of Science, and CBM as well as hand searching of the references of identified articles and the meeting abstracts were performed. Study selection, data abstraction and study quality evaluation were independently conducted in duplicate. Statistical analyses were performed using software Stata 11.0. The pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were performed. Different effects models were used according to the difference in heterogeneity. Publication bias was tested by Begg's funnel plot and Egger's regression test.

RESULTS

A total of 4 publications including 7 studies were involved. For rs12425791, significant association was found in allelic model (OR=1.06, 95%CI=1.00-1.11) and dominant model (OR=1.10, 95%CI=1.03-1.18), whereas no evidence of association was found for additive model (OR=1.04, 95%CI=0.93-1.17) and for recessive model (OR=0.99, 95%CI=0.88-1.10). For rs11833579, no evidence of association was found for all genetic models. In the analysis of Chinese Han population, there is lack of evidence for association of ischemic stroke for both SNPs.

CONCLUSIONS

In summary, our meta-analysis suggests that rs12425791 is significantly associated with ischemic stroke in East Asian population but not Chinese Han population, of which A alleles increase the risk of ischemic stroke, whereas no evidence of association was found for rs11833579 in East Asian population as well as Chinese Han population.

Authors+Show Affiliations

Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22297388

Citation

Li, Bing-Hu, et al. "Association Between 12p13 SNPs Rs11833579/rs12425791 Near NINJ2 Gene and Ischemic Stroke in East Asian Population: Evidence From a Meta-analysis." Journal of the Neurological Sciences, vol. 316, no. 1-2, 2012, pp. 116-21.
Li BH, Zhang LL, Yin YW, et al. Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis. J Neurol Sci. 2012;316(1-2):116-21.
Li, B. H., Zhang, L. L., Yin, Y. W., Pi, Y., Guo, L., Yang, Q. W., Gao, C. Y., Fang, C. Q., Wang, J. Z., & Li, J. C. (2012). Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis. Journal of the Neurological Sciences, 316(1-2), 116-21. https://doi.org/10.1016/j.jns.2012.01.010
Li BH, et al. Association Between 12p13 SNPs Rs11833579/rs12425791 Near NINJ2 Gene and Ischemic Stroke in East Asian Population: Evidence From a Meta-analysis. J Neurol Sci. 2012 May 15;316(1-2):116-21. PubMed PMID: 22297388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis. AU - Li,Bing-Hu, AU - Zhang,Li-Li, AU - Yin,Yan-Wei, AU - Pi,Yan, AU - Guo,Lu, AU - Yang,Qing-Wu, AU - Gao,Chang-Yue, AU - Fang,Chuan-Qin, AU - Wang,Jing-Zhou, AU - Li,Jing-Cheng, Y1 - 2012/01/30/ PY - 2011/10/29/received PY - 2012/01/09/revised PY - 2012/01/13/accepted PY - 2012/2/3/entrez PY - 2012/2/3/pubmed PY - 2013/1/23/medline SP - 116 EP - 21 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 316 IS - 1-2 N2 - BACKGROUND: Meta-analysis in European population found no association between rs12425791/rs11833579 and ischemic stroke. Several studies focused on East Asians have evaluated the association between this two SNPs and risk of ischemic stroke, but the results have been inconsistent. The aim of this study was to perform a meta-analysis to investigate a more authentic association between rs12425791 and rs11833579 G>A mutation and ischemic stroke in East Asian population, as well as in Chinese Han population. METHODS: Systematic searches of electronic databases Embase, PubMed, Web of Science, and CBM as well as hand searching of the references of identified articles and the meeting abstracts were performed. Study selection, data abstraction and study quality evaluation were independently conducted in duplicate. Statistical analyses were performed using software Stata 11.0. The pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were performed. Different effects models were used according to the difference in heterogeneity. Publication bias was tested by Begg's funnel plot and Egger's regression test. RESULTS: A total of 4 publications including 7 studies were involved. For rs12425791, significant association was found in allelic model (OR=1.06, 95%CI=1.00-1.11) and dominant model (OR=1.10, 95%CI=1.03-1.18), whereas no evidence of association was found for additive model (OR=1.04, 95%CI=0.93-1.17) and for recessive model (OR=0.99, 95%CI=0.88-1.10). For rs11833579, no evidence of association was found for all genetic models. In the analysis of Chinese Han population, there is lack of evidence for association of ischemic stroke for both SNPs. CONCLUSIONS: In summary, our meta-analysis suggests that rs12425791 is significantly associated with ischemic stroke in East Asian population but not Chinese Han population, of which A alleles increase the risk of ischemic stroke, whereas no evidence of association was found for rs11833579 in East Asian population as well as Chinese Han population. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/22297388/Association_between_12p13_SNPs_rs11833579/rs12425791_near_NINJ2_gene_and_ischemic_stroke_in_East_Asian_population:_evidence_from_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(12)00011-1 DB - PRIME DP - Unbound Medicine ER -