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Antioxidant and anti-inflammatory effects of a hypoglycemic fraction from Cucurbita ficifolia Bouché in streptozotocin-induced diabetes mice.
Am J Chin Med 2012; 40(1):97-110AJ

Abstract

Type 2 diabetes is characterized by oxidative stress and a chronic low-grade inflammatory state, which also play roles in the pathogenesis of this disease and the accompanying vascular complications by increasing the production of free radicals and pro-inflammatory cytokines. Cucurbita ficifolia Bouché (C. ficifolia) is an edible Mexican plant whose hypoglycemic activity has been demonstrated in several experimental and clinical conditions. Recently, D-chiro-inositol has been proposed as the compound responsible for the hypoglycemic effects; however, the antioxidant and anti-inflammatory potential of this plant has not yet been explored. The aim of this research is to study the influence of a hypoglycemic, D-chiro-inositol-containing fraction from the C. ficifolia fruit (AP-Fraction) on biomarkers of oxidative stress, as well as on the inflammatory cytokines in streptozotocin-induced diabetes. The AP-Fraction obtained from the mature fruit of C. ficifolia contained 3.31 mg of D-chiro-inositol/g of AP-Fraction. The AP-Fraction was administrated daily by gavage to normal mice for 15 days as a preventive treatment. Then these animals were given streptozotocin, and the treatments were continued for an additional 33 days. Pioglitazone was used as a hypoglycemic drug for comparison. Administration of the AP-Fraction significantly increased glutathione (GSH) and decreased malondialdehyde (MDA) in the liver without significantly affecting the levels in other tissues. The AP-Fraction reduced TNF-α and increased IL-6 and IFN-γ in serum. Interestingly, the AP-Fraction also increased IL-10, an anti-inflammatory cytokine. These results suggest that C. ficifolia might be used as an alternative medication for the control of diabetes mellitus and that it has antioxidant and anti-inflammatory properties in addition to its hypoglycemic activity.

Authors+Show Affiliations

Department of Health Sciences, Universidad Autonoma Metropolitana, Mexico, D.F., Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22298451

Citation

Roman-Ramos, R, et al. "Antioxidant and Anti-inflammatory Effects of a Hypoglycemic Fraction From Cucurbita Ficifolia Bouché in Streptozotocin-induced Diabetes Mice." The American Journal of Chinese Medicine, vol. 40, no. 1, 2012, pp. 97-110.
Roman-Ramos R, Almanza-Perez JC, Fortis-Barrera A, et al. Antioxidant and anti-inflammatory effects of a hypoglycemic fraction from Cucurbita ficifolia Bouché in streptozotocin-induced diabetes mice. Am J Chin Med. 2012;40(1):97-110.
Roman-Ramos, R., Almanza-Perez, J. C., Fortis-Barrera, A., Angeles-Mejia, S., Banderas-Dorantes, T. R., Zamilpa-Alvarez, A., ... Alarcon-Aguilar, F. J. (2012). Antioxidant and anti-inflammatory effects of a hypoglycemic fraction from Cucurbita ficifolia Bouché in streptozotocin-induced diabetes mice. The American Journal of Chinese Medicine, 40(1), pp. 97-110.
Roman-Ramos R, et al. Antioxidant and Anti-inflammatory Effects of a Hypoglycemic Fraction From Cucurbita Ficifolia Bouché in Streptozotocin-induced Diabetes Mice. Am J Chin Med. 2012;40(1):97-110. PubMed PMID: 22298451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and anti-inflammatory effects of a hypoglycemic fraction from Cucurbita ficifolia Bouché in streptozotocin-induced diabetes mice. AU - Roman-Ramos,R, AU - Almanza-Perez,J C, AU - Fortis-Barrera,A, AU - Angeles-Mejia,S, AU - Banderas-Dorantes,T R, AU - Zamilpa-Alvarez,A, AU - Diaz-Flores,M, AU - Jasso,I, AU - Blancas-Flores,G, AU - Gomez,J, AU - Alarcon-Aguilar,F J, PY - 2012/2/3/entrez PY - 2012/2/3/pubmed PY - 2012/6/26/medline SP - 97 EP - 110 JF - The American journal of Chinese medicine JO - Am. J. Chin. Med. VL - 40 IS - 1 N2 - Type 2 diabetes is characterized by oxidative stress and a chronic low-grade inflammatory state, which also play roles in the pathogenesis of this disease and the accompanying vascular complications by increasing the production of free radicals and pro-inflammatory cytokines. Cucurbita ficifolia Bouché (C. ficifolia) is an edible Mexican plant whose hypoglycemic activity has been demonstrated in several experimental and clinical conditions. Recently, D-chiro-inositol has been proposed as the compound responsible for the hypoglycemic effects; however, the antioxidant and anti-inflammatory potential of this plant has not yet been explored. The aim of this research is to study the influence of a hypoglycemic, D-chiro-inositol-containing fraction from the C. ficifolia fruit (AP-Fraction) on biomarkers of oxidative stress, as well as on the inflammatory cytokines in streptozotocin-induced diabetes. The AP-Fraction obtained from the mature fruit of C. ficifolia contained 3.31 mg of D-chiro-inositol/g of AP-Fraction. The AP-Fraction was administrated daily by gavage to normal mice for 15 days as a preventive treatment. Then these animals were given streptozotocin, and the treatments were continued for an additional 33 days. Pioglitazone was used as a hypoglycemic drug for comparison. Administration of the AP-Fraction significantly increased glutathione (GSH) and decreased malondialdehyde (MDA) in the liver without significantly affecting the levels in other tissues. The AP-Fraction reduced TNF-α and increased IL-6 and IFN-γ in serum. Interestingly, the AP-Fraction also increased IL-10, an anti-inflammatory cytokine. These results suggest that C. ficifolia might be used as an alternative medication for the control of diabetes mellitus and that it has antioxidant and anti-inflammatory properties in addition to its hypoglycemic activity. SN - 1793-6853 UR - https://www.unboundmedicine.com/medline/citation/22298451/Antioxidant_and_anti_inflammatory_effects_of_a_hypoglycemic_fraction_from_Cucurbita_ficifolia_Bouché_in_streptozotocin_induced_diabetes_mice_ L2 - https://www.worldscientific.com/doi/full/10.1142/S0192415X12500085?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -