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Down regulation in hypersensitivity pneumonitis.
J Allergy Clin Immunol. 1990 Nov; 86(5):821-5.JA

Abstract

Levels of soluble interleukin-2 receptor (sol-IL-2R) in the bronchoalveolar lavage fluid (BALF) of pigeon breeders with hypersensitivity pneumonitis were compared with BALF levels in asymptomatic pigeon breeders who had been exposed to pigeon allergens for an equivalent length of time. No mean difference in sol-IL-2R levels was detected when these levels were expressed per milliliter BALF, epithelial lining fluid, or per T-lymphocyte. In sarcoidosis, the availability of sol-IL-2R per T cell was significantly higher for the group with inactive sarcoidosis compared with the group with active sarcoidosis. The results do not support the hypothesis that down regulation, in subjects exposed to allergens causing hypersensitivity pneumonitis, is a function of cell-free sol-IL-2R levels in BALF. In the dynamic situation, however, the hypothesis appears tenable.

Authors+Show Affiliations

Department of Medical Microbiology, University of Wales College of Medicine, Health Park, Cardiff.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2229846

Citation

Edwards, J H., et al. "Down Regulation in Hypersensitivity Pneumonitis." The Journal of Allergy and Clinical Immunology, vol. 86, no. 5, 1990, pp. 821-5.
Edwards JH, Reynolds SP, Jones KP, et al. Down regulation in hypersensitivity pneumonitis. J Allergy Clin Immunol. 1990;86(5):821-5.
Edwards, J. H., Reynolds, S. P., Jones, K. P., & Davies, B. H. (1990). Down regulation in hypersensitivity pneumonitis. The Journal of Allergy and Clinical Immunology, 86(5), 821-5.
Edwards JH, et al. Down Regulation in Hypersensitivity Pneumonitis. J Allergy Clin Immunol. 1990;86(5):821-5. PubMed PMID: 2229846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Down regulation in hypersensitivity pneumonitis. AU - Edwards,J H, AU - Reynolds,S P, AU - Jones,K P, AU - Davies,B H, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 821 EP - 5 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 86 IS - 5 N2 - Levels of soluble interleukin-2 receptor (sol-IL-2R) in the bronchoalveolar lavage fluid (BALF) of pigeon breeders with hypersensitivity pneumonitis were compared with BALF levels in asymptomatic pigeon breeders who had been exposed to pigeon allergens for an equivalent length of time. No mean difference in sol-IL-2R levels was detected when these levels were expressed per milliliter BALF, epithelial lining fluid, or per T-lymphocyte. In sarcoidosis, the availability of sol-IL-2R per T cell was significantly higher for the group with inactive sarcoidosis compared with the group with active sarcoidosis. The results do not support the hypothesis that down regulation, in subjects exposed to allergens causing hypersensitivity pneumonitis, is a function of cell-free sol-IL-2R levels in BALF. In the dynamic situation, however, the hypothesis appears tenable. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/2229846/Down_regulation_in_hypersensitivity_pneumonitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(05)80189-7 DB - PRIME DP - Unbound Medicine ER -