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Effect of chronic exposure to simazine on oxidative stress and antioxidant response in common carp (Cyprinus carpio L.).
Environ Toxicol Pharmacol. 2012 Mar; 33(2):334-43.ET

Abstract

We investigated the chronic effect of simazine, an s-triazine herbicide commonly present in aquatic environments, on the antioxidant system and oxidative stress indices in common carp (Cyprinus carpio L.). Fish were exposed to sub-lethal concentrations of 0.06 μg l(-1) (environmental concentration in Czech rivers), 2 mg l(-1), and 4 mg l(-1) for 14, 28 and 60 days. Indices of oxidative stress [reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS)], and antioxidant parameters [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH)] in fish brain, gill, muscle, liver, and intestine were measured. Chronic exposure to simazine showed the impact of the increased production of ROS leading to oxidative damage to lipids, proteins, and inhibition of antioxidant capacity. Activity of the antioxidant enzymes SOD, CAT, GPx and GSH in groups with high concentrations (2 mg l(-1), 4 mg l(-1)) increased at 14 and 28 days, but decreased after 60 days exposure (p<0.01) as compared with the control group. Changes in enzyme activity were mainly in the liver, but also in gills and brain. Prolonged exposure to simazine resulted in excess ROS formation finally resulting in oxidative damage to cell lipids and proteins and also inhibited antioxidant capacities in common carp tissue.

Authors+Show Affiliations

Research Institute of Fish Culture and Hydrobiology, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Vodnany, Czech Republic. staraa01@frov.jcu.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22301164

Citation

Stara, Alzbeta, et al. "Effect of Chronic Exposure to Simazine On Oxidative Stress and Antioxidant Response in Common Carp (Cyprinus Carpio L.)." Environmental Toxicology and Pharmacology, vol. 33, no. 2, 2012, pp. 334-43.
Stara A, Machova J, Velisek J. Effect of chronic exposure to simazine on oxidative stress and antioxidant response in common carp (Cyprinus carpio L.). Environ Toxicol Pharmacol. 2012;33(2):334-43.
Stara, A., Machova, J., & Velisek, J. (2012). Effect of chronic exposure to simazine on oxidative stress and antioxidant response in common carp (Cyprinus carpio L.). Environmental Toxicology and Pharmacology, 33(2), 334-43. https://doi.org/10.1016/j.etap.2011.12.019
Stara A, Machova J, Velisek J. Effect of Chronic Exposure to Simazine On Oxidative Stress and Antioxidant Response in Common Carp (Cyprinus Carpio L.). Environ Toxicol Pharmacol. 2012;33(2):334-43. PubMed PMID: 22301164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of chronic exposure to simazine on oxidative stress and antioxidant response in common carp (Cyprinus carpio L.). AU - Stara,Alzbeta, AU - Machova,Jana, AU - Velisek,Josef, Y1 - 2011/12/26/ PY - 2011/07/13/received PY - 2011/12/08/revised PY - 2011/12/19/accepted PY - 2012/2/4/entrez PY - 2012/2/4/pubmed PY - 2012/6/13/medline SP - 334 EP - 43 JF - Environmental toxicology and pharmacology JO - Environ. Toxicol. Pharmacol. VL - 33 IS - 2 N2 - We investigated the chronic effect of simazine, an s-triazine herbicide commonly present in aquatic environments, on the antioxidant system and oxidative stress indices in common carp (Cyprinus carpio L.). Fish were exposed to sub-lethal concentrations of 0.06 μg l(-1) (environmental concentration in Czech rivers), 2 mg l(-1), and 4 mg l(-1) for 14, 28 and 60 days. Indices of oxidative stress [reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS)], and antioxidant parameters [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH)] in fish brain, gill, muscle, liver, and intestine were measured. Chronic exposure to simazine showed the impact of the increased production of ROS leading to oxidative damage to lipids, proteins, and inhibition of antioxidant capacity. Activity of the antioxidant enzymes SOD, CAT, GPx and GSH in groups with high concentrations (2 mg l(-1), 4 mg l(-1)) increased at 14 and 28 days, but decreased after 60 days exposure (p<0.01) as compared with the control group. Changes in enzyme activity were mainly in the liver, but also in gills and brain. Prolonged exposure to simazine resulted in excess ROS formation finally resulting in oxidative damage to cell lipids and proteins and also inhibited antioxidant capacities in common carp tissue. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/22301164/Effect_of_chronic_exposure_to_simazine_on_oxidative_stress_and_antioxidant_response_in_common_carp__Cyprinus_carpio_L___ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(11)00205-5 DB - PRIME DP - Unbound Medicine ER -