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Eco-toxicological effect of carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa.
Environ Toxicol Pharmacol. 2012 Mar; 33(2):344-52.ET

Abstract

The acute and chronic toxicological effects of carbamazepine (CBZ) on Scenedesmus obliquus and Chlorella pyrenoidosa were explored for the first time in this study. The results showed that CBZ could significantly inhibit the growth of the two algae in almost all treatment groups. EC(50) values indicated that, CBZ had a relatively limited acute toxic effect (0-144 h) on S. obliquus and C. pyrenoidosa, while, chronic tests (5-30 d) displayed higher toxicity. Chlorophyll a syntheses were nearly all inhibited by CBZ exposure. However, superoxide dismutase (SOD) and catalase (CAT) activities in acute tests of both algae were markedly promoted. According to the results, Chlorophyll a content and CAT activity of S. obliquus were more sensitive to CBZ than that of C. pyrenoidosa. While for SOD, quite to the contrary, C. pyrenoidosa was more vulnerable. We obtained a similar result in chronic tests. This research furthers our understanding of CBZ toxicity to aquatic organisms.

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Authors+Show Affiliations

Zhang W
School of Resource and Environmental Engineering/Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, PR China. wzhang@ecust.edu.cn
Zhang M
No affiliation info available
Lin K
No affiliation info available
Sun W
No affiliation info available
Xiong B
No affiliation info available
Guo M
No affiliation info available
Cui X
No affiliation info available
Fu R
No affiliation info available

MeSH

BiomarkersCarbamazepineCatalaseChlorellaChlorophyllChlorophyll ADose-Response Relationship, DrugEnvironmental MonitoringRisk AssessmentScenedesmusSuperoxide DismutaseTime FactorsToxicity TestsWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22301166

Citation

Zhang, Wei, et al. "Eco-toxicological Effect of Carbamazepine On Scenedesmus Obliquus and Chlorella Pyrenoidosa." Environmental Toxicology and Pharmacology, vol. 33, no. 2, 2012, pp. 344-52.
Zhang W, Zhang M, Lin K, et al. Eco-toxicological effect of carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa. Environ Toxicol Pharmacol. 2012;33(2):344-52.
Zhang, W., Zhang, M., Lin, K., Sun, W., Xiong, B., Guo, M., Cui, X., & Fu, R. (2012). Eco-toxicological effect of carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa. Environmental Toxicology and Pharmacology, 33(2), 344-52. https://doi.org/10.1016/j.etap.2011.12.024
Zhang W, et al. Eco-toxicological Effect of Carbamazepine On Scenedesmus Obliquus and Chlorella Pyrenoidosa. Environ Toxicol Pharmacol. 2012;33(2):344-52. PubMed PMID: 22301166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eco-toxicological effect of carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa. AU - Zhang,Wei, AU - Zhang,Meng, AU - Lin,Kuangfei, AU - Sun,Wenfang, AU - Xiong,Bang, AU - Guo,Meijin, AU - Cui,Xinhong, AU - Fu,Rongbing, Y1 - 2012/01/03/ PY - 2011/09/16/received PY - 2011/12/21/revised PY - 2011/12/22/accepted PY - 2012/2/4/entrez PY - 2012/2/4/pubmed PY - 2012/6/13/medline SP - 344 EP - 52 JF - Environmental toxicology and pharmacology JO - Environ Toxicol Pharmacol VL - 33 IS - 2 N2 - The acute and chronic toxicological effects of carbamazepine (CBZ) on Scenedesmus obliquus and Chlorella pyrenoidosa were explored for the first time in this study. The results showed that CBZ could significantly inhibit the growth of the two algae in almost all treatment groups. EC(50) values indicated that, CBZ had a relatively limited acute toxic effect (0-144 h) on S. obliquus and C. pyrenoidosa, while, chronic tests (5-30 d) displayed higher toxicity. Chlorophyll a syntheses were nearly all inhibited by CBZ exposure. However, superoxide dismutase (SOD) and catalase (CAT) activities in acute tests of both algae were markedly promoted. According to the results, Chlorophyll a content and CAT activity of S. obliquus were more sensitive to CBZ than that of C. pyrenoidosa. While for SOD, quite to the contrary, C. pyrenoidosa was more vulnerable. We obtained a similar result in chronic tests. This research furthers our understanding of CBZ toxicity to aquatic organisms. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/22301166/Eco_toxicological_effect_of_carbamazepine_on_Scenedesmus_obliquus_and_Chlorella_pyrenoidosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(11)00210-9 DB - PRIME DP - Unbound Medicine ER -