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Antioxidants and chronic pancreatitis: theory of oxidative stress and trials of antioxidant therapy.
Dig Dis Sci. 2012 Apr; 57(4):835-41.DD

Abstract

Chronic pancreatitis (CP) is an inflammatory disease characterized by the progressive destruction of pancreatic tissue and resulting in pancreatic exocrine and endocrine insufficiency. Increased oxidative stress has been implicated as a potential mechanism in its etiology and pathology. A number of studies have demonstrated that CP patients have a compromised antioxidant status, which may be a contributing factor to the enhanced oxidative state associated with the disease. Nutrition is an essential consideration in the treatment of CP, especially since diet is a source of several antioxidants and cofactors required for the production of cellular antioxidant enzymes. Many CP patients have an inadequate intake of macro and micronutrients because of abdominal pain and discomfort, which often increase postprandially and discourage eating. Exocrine insufficiency leads to further complications by preventing adequate digestion and absorption of ingested food, thus causing even greater deficiencies and impairment of antioxidant status. The aims of this article are to review the oxidative stress model of CP and to examine the evidence for nutrition, and, particularly, antioxidants, in the treatment of CP.

Authors+Show Affiliations

Department of Surgery, University of Arizona, 1656 E. Mabel St., Rm. 126, P.O. Box 245066, Tucson, AZ 85724, USA. brianna1@email.arizona.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22302241

Citation

Grigsby, Brianna, et al. "Antioxidants and Chronic Pancreatitis: Theory of Oxidative Stress and Trials of Antioxidant Therapy." Digestive Diseases and Sciences, vol. 57, no. 4, 2012, pp. 835-41.
Grigsby B, Rodriguez-Rilo H, Khan K. Antioxidants and chronic pancreatitis: theory of oxidative stress and trials of antioxidant therapy. Dig Dis Sci. 2012;57(4):835-41.
Grigsby, B., Rodriguez-Rilo, H., & Khan, K. (2012). Antioxidants and chronic pancreatitis: theory of oxidative stress and trials of antioxidant therapy. Digestive Diseases and Sciences, 57(4), 835-41. https://doi.org/10.1007/s10620-012-2037-3
Grigsby B, Rodriguez-Rilo H, Khan K. Antioxidants and Chronic Pancreatitis: Theory of Oxidative Stress and Trials of Antioxidant Therapy. Dig Dis Sci. 2012;57(4):835-41. PubMed PMID: 22302241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidants and chronic pancreatitis: theory of oxidative stress and trials of antioxidant therapy. AU - Grigsby,Brianna, AU - Rodriguez-Rilo,Horacio, AU - Khan,Khalid, PY - 2011/08/25/received PY - 2012/01/04/accepted PY - 2012/2/4/entrez PY - 2012/2/4/pubmed PY - 2012/5/9/medline SP - 835 EP - 41 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 57 IS - 4 N2 - Chronic pancreatitis (CP) is an inflammatory disease characterized by the progressive destruction of pancreatic tissue and resulting in pancreatic exocrine and endocrine insufficiency. Increased oxidative stress has been implicated as a potential mechanism in its etiology and pathology. A number of studies have demonstrated that CP patients have a compromised antioxidant status, which may be a contributing factor to the enhanced oxidative state associated with the disease. Nutrition is an essential consideration in the treatment of CP, especially since diet is a source of several antioxidants and cofactors required for the production of cellular antioxidant enzymes. Many CP patients have an inadequate intake of macro and micronutrients because of abdominal pain and discomfort, which often increase postprandially and discourage eating. Exocrine insufficiency leads to further complications by preventing adequate digestion and absorption of ingested food, thus causing even greater deficiencies and impairment of antioxidant status. The aims of this article are to review the oxidative stress model of CP and to examine the evidence for nutrition, and, particularly, antioxidants, in the treatment of CP. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/22302241/Antioxidants_and_chronic_pancreatitis:_theory_of_oxidative_stress_and_trials_of_antioxidant_therapy_ L2 - https://doi.org/10.1007/s10620-012-2037-3 DB - PRIME DP - Unbound Medicine ER -