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Fast and pH-dependent release of domperidone from orally disintegrating tablets.
Pharm Dev Technol. 2013 Jul-Aug; 18(4):897-905.PD

Abstract

There has been growing interest in orally disintegrating tablets (ODTs) during the last decade due to their better patient acceptance and compliance. Further, drug dissolution and absorption may be significantly improved. This work describes the preparation of fast and pH-dependent release ODTs for domperidone by direct compression using crospovidone as superdisintegrant. Solid dispersions of domperidone and Eudragit L100-55, at different weight ratios, were prepared and characterized by DSC, TGA, X-ray diffraction, and FTIR, which indicated the presence of drug-polymer interaction. Disintegration time, friability, and hardness of ODTs were evaluated. In vitro drug release in 0.1N HCl and in phosphate buffer (pH 5.8 and 6.8) was investigated. All domperidone ODTs had fast disintegration times (6 KP) and acceptable friability (<1%). Drug release from fast release ODTs was highly improved; reaching 97% after 10 min in 0.1N HCl, compared to the dissolution of the free drug. Drug release from solid dispersions was pH dependent; showing higher release rates at pH 6.8 than at lower pH values. The controlled-release ODT resulted in 47% drug release in 0.1N HCl, with the rest of drug released at pH 6.8. Domperidone ODTs were considered suitable for ODT formulation.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan. sheassaf@just.edu.joNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22304659

Citation

Assaf, Shereen M., et al. "Fast and pH-dependent Release of Domperidone From Orally Disintegrating Tablets." Pharmaceutical Development and Technology, vol. 18, no. 4, 2013, pp. 897-905.
Assaf SM, Qandil AM, Al-Ani EA. Fast and pH-dependent release of domperidone from orally disintegrating tablets. Pharm Dev Technol. 2013;18(4):897-905.
Assaf, S. M., Qandil, A. M., & Al-Ani, E. A. (2013). Fast and pH-dependent release of domperidone from orally disintegrating tablets. Pharmaceutical Development and Technology, 18(4), 897-905. https://doi.org/10.3109/10837450.2011.583925
Assaf SM, Qandil AM, Al-Ani EA. Fast and pH-dependent Release of Domperidone From Orally Disintegrating Tablets. Pharm Dev Technol. 2013 Jul-Aug;18(4):897-905. PubMed PMID: 22304659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fast and pH-dependent release of domperidone from orally disintegrating tablets. AU - Assaf,Shereen M, AU - Qandil,Amjad M, AU - Al-Ani,Enas A, Y1 - 2012/02/03/ PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2013/12/24/medline SP - 897 EP - 905 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 18 IS - 4 N2 - There has been growing interest in orally disintegrating tablets (ODTs) during the last decade due to their better patient acceptance and compliance. Further, drug dissolution and absorption may be significantly improved. This work describes the preparation of fast and pH-dependent release ODTs for domperidone by direct compression using crospovidone as superdisintegrant. Solid dispersions of domperidone and Eudragit L100-55, at different weight ratios, were prepared and characterized by DSC, TGA, X-ray diffraction, and FTIR, which indicated the presence of drug-polymer interaction. Disintegration time, friability, and hardness of ODTs were evaluated. In vitro drug release in 0.1N HCl and in phosphate buffer (pH 5.8 and 6.8) was investigated. All domperidone ODTs had fast disintegration times (6 KP) and acceptable friability (<1%). Drug release from fast release ODTs was highly improved; reaching 97% after 10 min in 0.1N HCl, compared to the dissolution of the free drug. Drug release from solid dispersions was pH dependent; showing higher release rates at pH 6.8 than at lower pH values. The controlled-release ODT resulted in 47% drug release in 0.1N HCl, with the rest of drug released at pH 6.8. Domperidone ODTs were considered suitable for ODT formulation. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/22304659/Fast_and_pH_dependent_release_of_domperidone_from_orally_disintegrating_tablets_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2011.583925 DB - PRIME DP - Unbound Medicine ER -