Citation
Aydogdu, Aydogan, et al. "High Plasma Level of Long Pentraxin 3 Is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 28, no. 9, 2012, pp. 722-5.
Aydogdu A, Tasci I, Tapan S, et al. High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome. Gynecol Endocrinol. 2012;28(9):722-5.
Aydogdu, A., Tasci, I., Tapan, S., Basaran, Y., Aydogan, U., Meric, C., Sonmez, A., Aydogdu, S., Akbulut, H., Taslipinar, A., Uckaya, G., & Azal, O. (2012). High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 28(9), 722-5. https://doi.org/10.3109/09513590.2011.652719
Aydogdu A, et al. High Plasma Level of Long Pentraxin 3 Is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2012;28(9):722-5. PubMed PMID: 22304663.
TY - JOUR
T1 - High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome.
AU - Aydogdu,Aydogan,
AU - Tasci,Ilker,
AU - Tapan,Serkan,
AU - Basaran,Yalcin,
AU - Aydogan,Umit,
AU - Meric,Coskun,
AU - Sonmez,Alper,
AU - Aydogdu,Sebnem,
AU - Akbulut,Halil,
AU - Taslipinar,Abdullah,
AU - Uckaya,Gokhan,
AU - Azal,Omer,
Y1 - 2012/02/04/
PY - 2012/2/7/entrez
PY - 2012/2/7/pubmed
PY - 2013/1/15/medline
SP - 722
EP - 5
JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
JO - Gynecol Endocrinol
VL - 28
IS - 9
N2 - OBJECTIVES: Polycystic ovary syndrome (PCOS) is characterized by insulin resistance. Chronic low-grade inflammation has been anticipated to play role in the pathogenesis of both insulin resistance and atherosclerosis. Pentraxin 3 (PTX3) is an inflammatory mediator synthesized in a variety of cells and tissues including heart, vascular endothelial cells, macrophages and adipocytes. In the present study, serum PTX3 level and its relationship with insulin resistance were investigated in patients with PCOS. MATERIALS AND METHODS: Forty patients with PCOS and 40 age- and body mass index (BMI)-matched healthy controls were enrolled in the study. PTX3 and high-sensitivity C-reactive protein (hs-CRP) levels were determined by enzyme immunoassay (EIA). Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) formula. RESULTS: Plasma levels of PTX3, hs-CRP and HOMA-IR scores were all significantly higher (p = 0.021, p = 0.002 and p = 0.0001, respectively) in women with PCOS compared with healthy controls. Blood PTX3 level correlated positively with hs-CRP, BMI, waist-to-hip ratio (WHR), HOMA-IR and negatively with high-density lipoprotein cholesterol level (p < 0.05, for all). After adjustment for age and BMI, PTX3, total testosterone levels and BMI remained as independent predictors of HOMA-IR scores (p < 0.05, for all). CONCLUSION: PTX3 level is increased in patients with PCOS in concordance with insulin resistance.
SN - 1473-0766
UR - https://www.unboundmedicine.com/medline/citation/22304663/High_plasma_level_of_long_Pentraxin_3_is_associated_with_insulin_resistance_in_women_with_polycystic_ovary_syndrome_
L2 - https://www.tandfonline.com/doi/full/10.3109/09513590.2011.652719
DB - PRIME
DP - Unbound Medicine
ER -
