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Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial.
Mayo Clin Proc. 2012 Feb; 87(2):143-50.MC

Abstract

OBJECTIVE

To compare the time to urinary tract infection (UTI) and the rates of asymptomatic bacteriuria and urinary P-fimbriated Escherichia coli during a 6-month period in women ingesting cranberry vs placebo juice daily.

PATIENTS AND METHODS

Premenopausal women with a history of recent UTI were enrolled from November 16, 2005, through December 31, 2008, at 2 centers and randomized to 1 of 3 arms: 4 oz of cranberry juice daily, 8 oz of cranberry juice daily, or placebo juice. Time to UTI (symptoms plus pyuria) was the main outcome. Asymptomatic bacteriuria, adherence, and adverse effects were assessed at monthly visits.

RESULTS

A total of 176 participants were randomized (120 to cranberry juice and 56 to placebo) and followed up for a median of 168 days. The cumulative rate of UTI was 0.29 in the cranberry juice group and 0.37 in the placebo group (P=.82). The adjusted hazard ratio for UTI in the cranberry juice group vs the placebo group was 0.68 (95% confidence interval, 0.33-1.39; P=.29). The proportion of women with P-fimbriated urinary E coli isolates during the intervention phase was 10 of 23 (43.5%) in the cranberry juice group and 8 of 10 (80.0%) in the placebo group (P=.07). The mean dose adherence was 91.8% and 90.3% in the cranberry juice group vs the placebo group. Minor adverse effects were reported by 24.2% of those in the cranberry juice group and 12.5% in the placebo group (P=.07).

CONCLUSION

Cranberry juice did not significantly reduce UTI risk compared with placebo. The potential protective effect we observed is consistent with previous studies and warrants confirmation in larger, well-powered studies of women with recurrent UTI. The concurrent reduction in urinary P-fimbriated E coli strains supports the biological plausibility of cranberry activity.

TRIAL REGISTRATION

clinicaltrials.gov Identifier: NCT00128128.

Authors+Show Affiliations

Department of Medicine, University of Washington, Seattle, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22305026

Citation

Stapleton, Ann E., et al. "Recurrent Urinary Tract Infection and Urinary Escherichia Coli in Women Ingesting Cranberry Juice Daily: a Randomized Controlled Trial." Mayo Clinic Proceedings, vol. 87, no. 2, 2012, pp. 143-50.
Stapleton AE, Dziura J, Hooton TM, et al. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo Clin Proc. 2012;87(2):143-50.
Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., & Gupta, K. (2012). Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo Clinic Proceedings, 87(2), 143-50. https://doi.org/10.1016/j.mayocp.2011.10.006
Stapleton AE, et al. Recurrent Urinary Tract Infection and Urinary Escherichia Coli in Women Ingesting Cranberry Juice Daily: a Randomized Controlled Trial. Mayo Clin Proc. 2012;87(2):143-50. PubMed PMID: 22305026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. AU - Stapleton,Ann E, AU - Dziura,James, AU - Hooton,Thomas M, AU - Cox,Marsha E, AU - Yarova-Yarovaya,Yuliya, AU - Chen,Shu, AU - Gupta,Kalpana, PY - 2011/07/22/received PY - 2011/09/14/revised PY - 2011/10/27/accepted PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2012/3/27/medline SP - 143 EP - 50 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 87 IS - 2 N2 - OBJECTIVE: To compare the time to urinary tract infection (UTI) and the rates of asymptomatic bacteriuria and urinary P-fimbriated Escherichia coli during a 6-month period in women ingesting cranberry vs placebo juice daily. PATIENTS AND METHODS: Premenopausal women with a history of recent UTI were enrolled from November 16, 2005, through December 31, 2008, at 2 centers and randomized to 1 of 3 arms: 4 oz of cranberry juice daily, 8 oz of cranberry juice daily, or placebo juice. Time to UTI (symptoms plus pyuria) was the main outcome. Asymptomatic bacteriuria, adherence, and adverse effects were assessed at monthly visits. RESULTS: A total of 176 participants were randomized (120 to cranberry juice and 56 to placebo) and followed up for a median of 168 days. The cumulative rate of UTI was 0.29 in the cranberry juice group and 0.37 in the placebo group (P=.82). The adjusted hazard ratio for UTI in the cranberry juice group vs the placebo group was 0.68 (95% confidence interval, 0.33-1.39; P=.29). The proportion of women with P-fimbriated urinary E coli isolates during the intervention phase was 10 of 23 (43.5%) in the cranberry juice group and 8 of 10 (80.0%) in the placebo group (P=.07). The mean dose adherence was 91.8% and 90.3% in the cranberry juice group vs the placebo group. Minor adverse effects were reported by 24.2% of those in the cranberry juice group and 12.5% in the placebo group (P=.07). CONCLUSION: Cranberry juice did not significantly reduce UTI risk compared with placebo. The potential protective effect we observed is consistent with previous studies and warrants confirmation in larger, well-powered studies of women with recurrent UTI. The concurrent reduction in urinary P-fimbriated E coli strains supports the biological plausibility of cranberry activity. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00128128. SN - 1942-5546 UR - https://www.unboundmedicine.com/medline/citation/22305026/Recurrent_urinary_tract_infection_and_urinary_Escherichia_coli_in_women_ingesting_cranberry_juice_daily:_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(11)00074-7 DB - PRIME DP - Unbound Medicine ER -