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Cytotoxic terpenoids from Juglans sinensis leaves and twigs.
Bioorg Med Chem Lett. 2012 Mar 01; 22(5):2079-83.BM

Abstract

Bioassay-guided fractionation of an 80% MeOH extract of Juglan sinensis leaves and twigs has resulted in the isolation of three new triterpenes (1-3) and two new sesquiterpenes (4-5) along with two known sesquiterpenes (6-7). The new compounds were determined to be 3β, 11α, 19α, 24, 30-pentahydroxy-20β, 28-epoxy-28β-methoxy-ursane (1), 1α, 3β-dihydroxy-olean-18-ene (2), 2α, 3α, 23-trihydroxy-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (3), (4S, 5S, 7R, 8R, 14R)-8, 11-dihydroxy-2, 4-cyclo-eudesmane (4), 15-hydroxy-α-eudesmol-11-O-β-d-glucopyranoside (5), by spectroscopic analysis. The cytotoxicity of compounds (1-7) against four cancer cell lines such as B16F10, Hep-2, MCF-7 and U87-MG was evaluated. Compounds 1, 2, 6 and 7 showed potent cytotoxicity against all of four cancer cell lines, respectively.

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Authors+Show Affiliations

Yang H
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Daehak-Dong, Gwanak-Gu, Seoul 151-742, Republic of Korea.
Cho HJ
No affiliation info available
Sim SH
No affiliation info available
Chung YK
No affiliation info available
Kim DD
No affiliation info available
Sung SH
No affiliation info available
Kim J
No affiliation info available
Kim YC
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalHumansJuglansNeoplasmsPlant LeavesSesquiterpenesTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22305494

Citation

Yang, Heejung, et al. "Cytotoxic Terpenoids From Juglans Sinensis Leaves and Twigs." Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 5, 2012, pp. 2079-83.
Yang H, Cho HJ, Sim SH, et al. Cytotoxic terpenoids from Juglans sinensis leaves and twigs. Bioorg Med Chem Lett. 2012;22(5):2079-83.
Yang, H., Cho, H. J., Sim, S. H., Chung, Y. K., Kim, D. D., Sung, S. H., Kim, J., & Kim, Y. C. (2012). Cytotoxic terpenoids from Juglans sinensis leaves and twigs. Bioorganic & Medicinal Chemistry Letters, 22(5), 2079-83. https://doi.org/10.1016/j.bmcl.2012.01.010
Yang H, et al. Cytotoxic Terpenoids From Juglans Sinensis Leaves and Twigs. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2079-83. PubMed PMID: 22305494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic terpenoids from Juglans sinensis leaves and twigs. AU - Yang,Heejung, AU - Cho,Hyun-Jong, AU - Sim,So Hee, AU - Chung,Young Keun, AU - Kim,Dae-Duk, AU - Sung,Sang Hyun, AU - Kim,Jinwoong, AU - Kim,Young Choong, Y1 - 2012/01/13/ PY - 2011/11/22/received PY - 2012/01/03/revised PY - 2012/01/04/accepted PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2012/6/19/medline SP - 2079 EP - 83 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 22 IS - 5 N2 - Bioassay-guided fractionation of an 80% MeOH extract of Juglan sinensis leaves and twigs has resulted in the isolation of three new triterpenes (1-3) and two new sesquiterpenes (4-5) along with two known sesquiterpenes (6-7). The new compounds were determined to be 3β, 11α, 19α, 24, 30-pentahydroxy-20β, 28-epoxy-28β-methoxy-ursane (1), 1α, 3β-dihydroxy-olean-18-ene (2), 2α, 3α, 23-trihydroxy-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (3), (4S, 5S, 7R, 8R, 14R)-8, 11-dihydroxy-2, 4-cyclo-eudesmane (4), 15-hydroxy-α-eudesmol-11-O-β-d-glucopyranoside (5), by spectroscopic analysis. The cytotoxicity of compounds (1-7) against four cancer cell lines such as B16F10, Hep-2, MCF-7 and U87-MG was evaluated. Compounds 1, 2, 6 and 7 showed potent cytotoxicity against all of four cancer cell lines, respectively. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/22305494/Cytotoxic_terpenoids_from_Juglans_sinensis_leaves_and_twigs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(12)00023-6 DB - PRIME DP - Unbound Medicine ER -