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Systematic review of soy isoflavone supplements on osteoporosis in women.
Asian Pac J Trop Med. 2012 Mar; 5(3):243-8.AP

Abstract

OBJECTIVE

To clarify the effect of soy isoflavones on prevention of osteoporosis, and the effective dosage of soy isoflavones and its duration.

METHODS

Random control trials that investigated the association of soy isoflavones and osteoporosis were included in the meta-analysis by researching MEDLINE, EMBASE and the Chinese Biomedical Database up to October 2011. The Rev Man software was used for all of the statistical analysis.

RESULTS

The present meta-analysis found that soy isoflavones significantly increased the bone mineral density by 54% and decreased the bone resorption marker urinary deoxypyridinoline (DPD) by 23% compared to baseline in women. Using random effects model, the effect of isoflavones on bone mineral density (BMD) regarding menopausal status and isoflavone dose revealed higher weighted mean difference changes were found in postmenopausal women and isoflavone dose above 75 mg/d. Subgroup analysis of trials with menopausal status, supplement type, isoflavone dose and intervention duration that used soy isoflavone extracts resulted in significant different overall effect of DPD using by random effects model. Sensitivity analysis indicated that the effect of soy isoflavones on BMD and DPD was robust.

CONCLUSIONS

The present meta-analysis reveals that soy isoflavone supplements significantly increase bone mineral density and decrease the bone resorption marker urinary DPD. It shows no significant effect on bone formation markers serum bone alkaline phosphatase. The significant effect of soy isoflavones on BMD and urinary DPD is relative to menopausal status, supplement type, isoflavone dose and intervention duration.

Authors+Show Affiliations

Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

22305793

Citation

Wei, Pan, et al. "Systematic Review of Soy Isoflavone Supplements On Osteoporosis in Women." Asian Pacific Journal of Tropical Medicine, vol. 5, no. 3, 2012, pp. 243-8.
Wei P, Liu M, Chen Y, et al. Systematic review of soy isoflavone supplements on osteoporosis in women. Asian Pac J Trop Med. 2012;5(3):243-8.
Wei, P., Liu, M., Chen, Y., & Chen, D. C. (2012). Systematic review of soy isoflavone supplements on osteoporosis in women. Asian Pacific Journal of Tropical Medicine, 5(3), 243-8. https://doi.org/10.1016/S1995-7645(12)60033-9
Wei P, et al. Systematic Review of Soy Isoflavone Supplements On Osteoporosis in Women. Asian Pac J Trop Med. 2012;5(3):243-8. PubMed PMID: 22305793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review of soy isoflavone supplements on osteoporosis in women. AU - Wei,Pan, AU - Liu,Ming, AU - Chen,Yan, AU - Chen,De-Cai, PY - 2011/11/18/received PY - 2011/12/15/revised PY - 2012/01/15/accepted PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2012/3/30/medline SP - 243 EP - 8 JF - Asian Pacific journal of tropical medicine JO - Asian Pac J Trop Med VL - 5 IS - 3 N2 - OBJECTIVE: To clarify the effect of soy isoflavones on prevention of osteoporosis, and the effective dosage of soy isoflavones and its duration. METHODS: Random control trials that investigated the association of soy isoflavones and osteoporosis were included in the meta-analysis by researching MEDLINE, EMBASE and the Chinese Biomedical Database up to October 2011. The Rev Man software was used for all of the statistical analysis. RESULTS: The present meta-analysis found that soy isoflavones significantly increased the bone mineral density by 54% and decreased the bone resorption marker urinary deoxypyridinoline (DPD) by 23% compared to baseline in women. Using random effects model, the effect of isoflavones on bone mineral density (BMD) regarding menopausal status and isoflavone dose revealed higher weighted mean difference changes were found in postmenopausal women and isoflavone dose above 75 mg/d. Subgroup analysis of trials with menopausal status, supplement type, isoflavone dose and intervention duration that used soy isoflavone extracts resulted in significant different overall effect of DPD using by random effects model. Sensitivity analysis indicated that the effect of soy isoflavones on BMD and DPD was robust. CONCLUSIONS: The present meta-analysis reveals that soy isoflavone supplements significantly increase bone mineral density and decrease the bone resorption marker urinary DPD. It shows no significant effect on bone formation markers serum bone alkaline phosphatase. The significant effect of soy isoflavones on BMD and urinary DPD is relative to menopausal status, supplement type, isoflavone dose and intervention duration. SN - 2352-4146 UR - https://www.unboundmedicine.com/medline/citation/22305793/Systematic_review_of_soy_isoflavone_supplements_on_osteoporosis_in_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1995-7645(12)60033-9 DB - PRIME DP - Unbound Medicine ER -