TY - JOUR T1 - Cationic cyclodextrins chemically-bonded chiral stationary phases for high-performance liquid chromatography. AU - Wang,Ren-Qi, AU - Ong,Teng-Teng, AU - Tang,Weihua, AU - Ng,Siu-Choon, Y1 - 2012/01/08/ PY - 2011/10/19/received PY - 2011/12/13/revised PY - 2011/12/24/accepted PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2012/5/23/medline SP - 121 EP - 9 JF - Analytica chimica acta JO - Anal Chim Acta VL - 718 N2 - Two covalently bonded cationic β-CD chiral stationary phases (CSPs) prepared by graft polymerization of 6(A)-(3-vinylimidazolium)-6-deoxyperphenylcarbamate-β-cyclodextrin chloride or 6(A)-(N,N-allylmethylammonium)-6-deoxyperphenylcarbamoyl-β-cyclodextrin chloride onto silica gel were successfully applied in high-performance liquid chromatography (HPLC). Their enantioseparation capability was examined with 12 racemic pharmaceuticals and 6 carboxylic acids. The results indicated that imidazolium-containing β-CD CSP afforded more favorable enantioseparations than that containing ammonium moiety under normal-phase HPLC. The cationic moiety on β-CD CSPs could form strong hydrogen bonding with analytes in normal-phase liquid chromatography (NPLC) to enhance the analytes' retention and enantioseparations. In reversed-phase liquid chromatography (RPLC), the analytes exhibited their maximum retention when the pH of mobile phase was close to their pK(a) value. Inclusion complexation with CD cavity and columbic/ionic interactions with cationic substituent on the CD rim would afford accentuated retention and enantioseparations of the analytes. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/22305907/Cationic_cyclodextrins_chemically_bonded_chiral_stationary_phases_for_high_performance_liquid_chromatography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(12)00004-9 DB - PRIME DP - Unbound Medicine ER -