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Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia.
J Ethnopharmacol 2012; 140(2):345-67JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Traditional Chinese medicine (TCM) formulas have been widely used in China since ancient times to treat certain diseases (e.g., phlegm, dampness and blood stasis). Recently, the effects of these medicines have been increasingly demonstrated to be helpful for hyperlipidemic patients.

AIM OF THE STUDY

This manuscript aims to describe the scientific evidence for the efficacy of TCM and attempts to identify potential TCM formulas for treating hyperlipidemia.

MATERIALS AND METHODS

TCM formulas approved by the State Food and Drug Administration of China (SFDA) were sourced from the official SFDA website (http://www.sda.gov.cn/). Human and animal evidence for the hypolipidemic effects of herbs from TCM formulas were reviewed via the Internet (Elsevier, ACS, Wiley Online Library, SpringerLink, PubMed, Web of Science, CNKI, Baidu, and Google) and libraries up to October 31, 2011.

RESULTS

More than 50 TCM formulas have been used to treat hyperlipidemia. These herbs can primarily be grouped into three categories: (1) herbs promoting excretions, generally by reducing food retention, enhancing purgative effects, and promoting diuresis and choleretic effects, e.g., Fructus Crataegi (), Radix Polygoni Multiflori (), Semen Cassiae (), and Radix et Rhizoma Rhei (), Rhizoma alismatis (), and Herba Artemisiae Scopariae (); (2) herbs acting on the cardiovascular system, generally by improving blood circulation based on TCM theories, e.g., Radix Salviae Miltiorrhizae (), Radix Puerariae (), Rhizoma Chuanxiong (), Flos Carthami (), and Folium Nelumbinis (); and (3) herbs that have tonic effects, e.g., Fructus Lycii (), Radix Ginseng (), and Radix Astragali ().

CONCLUSIONS

Three basic approaches, including excretory function enhancement, cardiovascular system improvement, and tonic effect reinforcement, are emerging among TCM formulas for the treatment of hyperlipidemia. These approaches may be useful in controlling blood lipid levels, preventing cardiovascular complications, and adjusting bodily functions in hyperlipidemic patients. However, solid evidence of the efficacy of these treatments is required.

Authors+Show Affiliations

Division of Life Science & Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22306102

Citation

Xie, Weidong, et al. "Emerging Approaches of Traditional Chinese Medicine Formulas for the Treatment of Hyperlipidemia." Journal of Ethnopharmacology, vol. 140, no. 2, 2012, pp. 345-67.
Xie W, Zhao Y, Du L. Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia. J Ethnopharmacol. 2012;140(2):345-67.
Xie, W., Zhao, Y., & Du, L. (2012). Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia. Journal of Ethnopharmacology, 140(2), pp. 345-67. doi:10.1016/j.jep.2012.01.027.
Xie W, Zhao Y, Du L. Emerging Approaches of Traditional Chinese Medicine Formulas for the Treatment of Hyperlipidemia. J Ethnopharmacol. 2012 Mar 27;140(2):345-67. PubMed PMID: 22306102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia. AU - Xie,Weidong, AU - Zhao,Yunan, AU - Du,Lijun, Y1 - 2012/01/26/ PY - 2011/11/10/received PY - 2012/01/14/revised PY - 2012/01/16/accepted PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2012/8/3/medline SP - 345 EP - 67 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 140 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine (TCM) formulas have been widely used in China since ancient times to treat certain diseases (e.g., phlegm, dampness and blood stasis). Recently, the effects of these medicines have been increasingly demonstrated to be helpful for hyperlipidemic patients. AIM OF THE STUDY: This manuscript aims to describe the scientific evidence for the efficacy of TCM and attempts to identify potential TCM formulas for treating hyperlipidemia. MATERIALS AND METHODS: TCM formulas approved by the State Food and Drug Administration of China (SFDA) were sourced from the official SFDA website (http://www.sda.gov.cn/). Human and animal evidence for the hypolipidemic effects of herbs from TCM formulas were reviewed via the Internet (Elsevier, ACS, Wiley Online Library, SpringerLink, PubMed, Web of Science, CNKI, Baidu, and Google) and libraries up to October 31, 2011. RESULTS: More than 50 TCM formulas have been used to treat hyperlipidemia. These herbs can primarily be grouped into three categories: (1) herbs promoting excretions, generally by reducing food retention, enhancing purgative effects, and promoting diuresis and choleretic effects, e.g., Fructus Crataegi (), Radix Polygoni Multiflori (), Semen Cassiae (), and Radix et Rhizoma Rhei (), Rhizoma alismatis (), and Herba Artemisiae Scopariae (); (2) herbs acting on the cardiovascular system, generally by improving blood circulation based on TCM theories, e.g., Radix Salviae Miltiorrhizae (), Radix Puerariae (), Rhizoma Chuanxiong (), Flos Carthami (), and Folium Nelumbinis (); and (3) herbs that have tonic effects, e.g., Fructus Lycii (), Radix Ginseng (), and Radix Astragali (). CONCLUSIONS: Three basic approaches, including excretory function enhancement, cardiovascular system improvement, and tonic effect reinforcement, are emerging among TCM formulas for the treatment of hyperlipidemia. These approaches may be useful in controlling blood lipid levels, preventing cardiovascular complications, and adjusting bodily functions in hyperlipidemic patients. However, solid evidence of the efficacy of these treatments is required. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22306102/Emerging_approaches_of_traditional_Chinese_medicine_formulas_for_the_treatment_of_hyperlipidemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00040-2 DB - PRIME DP - Unbound Medicine ER -