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In vitro antioxidant, antidiabetic and antilipidemic activities of Symplocos cochinchinensis (Lour.) S. Moore bark.
Food Chem Toxicol. 2012 May; 50(5):1547-53.FC

Abstract

Symplocos cochinchinesis is used in Indian system of traditional medicine to treat diabetes mellitus. The present study investigates the in vitro antioxidant, antidiabetic and antilipidemic activities of S. cochinchinensis bark methanolic extract (SCBe) in streptozotocin (STZ) induced diabetic rats. In in vitro studies SCBe showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC(50) 820.34 ± 1.74 μg/ml), hydroxyl (IC(50) 884.19 ± 0.45 μg/ml) and nitric oxide (IC(50) 860.21 ± 1.18 μg/ml) radicals, as well as high reducing power. SCBe (250 and 500 mg/kg) was administered to STZ (40 mg/kg) induced diabetic rats for 28 days. SCBe showed a significant decrease in blood glucose and significant increase in plasma insulin and liver glycogen levels in treated diabetic rats. Further, SCBe showed antilipidemic activity as evidenced by significant decrease in serum TC, TG, LDL-C levels and significant increase in HDL-C level in treated diabetic rats. SCBe also restored the altered plasma enzymes (SGOT, SGPT and ALP), total protein, urea and creatinine levels to near normal. The action of SCBe was comparable to the antidiabetic drug glibenclamide. Results of this experimental study indicated that SCBe possessed antioxidant, antidiabetic and antilipidemic activities.

Authors+Show Affiliations

Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22306921

Citation

Sunil, Christudas, et al. "In Vitro Antioxidant, Antidiabetic and Antilipidemic Activities of Symplocos Cochinchinensis (Lour.) S. Moore Bark." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 50, no. 5, 2012, pp. 1547-53.
Sunil C, Agastian P, Kumarappan C, et al. In vitro antioxidant, antidiabetic and antilipidemic activities of Symplocos cochinchinensis (Lour.) S. Moore bark. Food Chem Toxicol. 2012;50(5):1547-53.
Sunil, C., Agastian, P., Kumarappan, C., & Ignacimuthu, S. (2012). In vitro antioxidant, antidiabetic and antilipidemic activities of Symplocos cochinchinensis (Lour.) S. Moore bark. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 50(5), 1547-53. https://doi.org/10.1016/j.fct.2012.01.029
Sunil C, et al. In Vitro Antioxidant, Antidiabetic and Antilipidemic Activities of Symplocos Cochinchinensis (Lour.) S. Moore Bark. Food Chem Toxicol. 2012;50(5):1547-53. PubMed PMID: 22306921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antioxidant, antidiabetic and antilipidemic activities of Symplocos cochinchinensis (Lour.) S. Moore bark. AU - Sunil,Christudas, AU - Agastian,Paul, AU - Kumarappan,Chidambarm, AU - Ignacimuthu,Savarimuthu, Y1 - 2012/01/28/ PY - 2011/11/17/received PY - 2012/01/18/revised PY - 2012/01/20/accepted PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2012/8/25/medline SP - 1547 EP - 53 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 50 IS - 5 N2 - Symplocos cochinchinesis is used in Indian system of traditional medicine to treat diabetes mellitus. The present study investigates the in vitro antioxidant, antidiabetic and antilipidemic activities of S. cochinchinensis bark methanolic extract (SCBe) in streptozotocin (STZ) induced diabetic rats. In in vitro studies SCBe showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC(50) 820.34 ± 1.74 μg/ml), hydroxyl (IC(50) 884.19 ± 0.45 μg/ml) and nitric oxide (IC(50) 860.21 ± 1.18 μg/ml) radicals, as well as high reducing power. SCBe (250 and 500 mg/kg) was administered to STZ (40 mg/kg) induced diabetic rats for 28 days. SCBe showed a significant decrease in blood glucose and significant increase in plasma insulin and liver glycogen levels in treated diabetic rats. Further, SCBe showed antilipidemic activity as evidenced by significant decrease in serum TC, TG, LDL-C levels and significant increase in HDL-C level in treated diabetic rats. SCBe also restored the altered plasma enzymes (SGOT, SGPT and ALP), total protein, urea and creatinine levels to near normal. The action of SCBe was comparable to the antidiabetic drug glibenclamide. Results of this experimental study indicated that SCBe possessed antioxidant, antidiabetic and antilipidemic activities. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/22306921/In_vitro_antioxidant_antidiabetic_and_antilipidemic_activities_of_Symplocos_cochinchinensis__Lour___S__Moore_bark_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(12)00056-7 DB - PRIME DP - Unbound Medicine ER -