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Zinc and liver disease.
Nutr Clin Pract 2012; 27(1):8-20NC

Abstract

Zinc is an essential trace element required for normal cell growth, development, and differentiation. It is involved in DNA synthesis, RNA transcription, and cell division and activation. It is a critical component in many zinc protein/enzymes, including critical zinc transcription factors. Zinc deficiency/altered metabolism is observed in many types of liver disease, including alcoholic liver disease (ALD) and viral liver disease. Some of the mechanisms for zinc deficiency/altered metabolism include decreased dietary intake, increased urinary excretion, activation of certain zinc transporters, and induction of hepatic metallothionein. Zinc deficiency may manifest itself in many ways in liver disease, including skin lesions, poor wound healing/liver regeneration, altered mental status, or altered immune function. Zinc supplementation has been documented to block/attenuate experimental ALD through multiple processes, including stabilization of gut-barrier function, decreasing endotoxemia, decreasing proinflammatory cytokine production, decreasing oxidative stress, and attenuating apoptotic hepatocyte death. Clinical trials in human liver disease are limited in size and quality, but it is clear that zinc supplementation reverses clinical signs of zinc deficiency in patients with liver disease. Some studies suggest improvement in liver function in both ALD and hepatitis C following zinc supplementation, and 1 study suggested improved fibrosis markers in hepatitis C patients. The dose of zinc used for treatment of liver disease is usually 50 mg of elemental zinc taken with a meal to decrease the potential side effect of nausea.

Authors+Show Affiliations

University of Louisville, Louisville, KY, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22307488

Citation

Mohammad, Mohammad K., et al. "Zinc and Liver Disease." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 27, no. 1, 2012, pp. 8-20.
Mohammad MK, Mohommad MK, Zhou Z, et al. Zinc and liver disease. Nutr Clin Pract. 2012;27(1):8-20.
Mohammad, M. K., Mohommad, M. K., Zhou, Z., Cave, M., Barve, A., & McClain, C. J. (2012). Zinc and liver disease. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 27(1), pp. 8-20. doi:10.1177/0884533611433534.
Mohammad MK, et al. Zinc and Liver Disease. Nutr Clin Pract. 2012;27(1):8-20. PubMed PMID: 22307488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc and liver disease. AU - Mohammad,Mohammad K, AU - Mohommad,Mohammad K, AU - Zhou,Zhanxiang, AU - Cave,Matthew, AU - Barve,Ashutosh, AU - McClain,Craig J, PY - 2012/2/7/entrez PY - 2012/2/7/pubmed PY - 2012/7/28/medline SP - 8 EP - 20 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 27 IS - 1 N2 - Zinc is an essential trace element required for normal cell growth, development, and differentiation. It is involved in DNA synthesis, RNA transcription, and cell division and activation. It is a critical component in many zinc protein/enzymes, including critical zinc transcription factors. Zinc deficiency/altered metabolism is observed in many types of liver disease, including alcoholic liver disease (ALD) and viral liver disease. Some of the mechanisms for zinc deficiency/altered metabolism include decreased dietary intake, increased urinary excretion, activation of certain zinc transporters, and induction of hepatic metallothionein. Zinc deficiency may manifest itself in many ways in liver disease, including skin lesions, poor wound healing/liver regeneration, altered mental status, or altered immune function. Zinc supplementation has been documented to block/attenuate experimental ALD through multiple processes, including stabilization of gut-barrier function, decreasing endotoxemia, decreasing proinflammatory cytokine production, decreasing oxidative stress, and attenuating apoptotic hepatocyte death. Clinical trials in human liver disease are limited in size and quality, but it is clear that zinc supplementation reverses clinical signs of zinc deficiency in patients with liver disease. Some studies suggest improvement in liver function in both ALD and hepatitis C following zinc supplementation, and 1 study suggested improved fibrosis markers in hepatitis C patients. The dose of zinc used for treatment of liver disease is usually 50 mg of elemental zinc taken with a meal to decrease the potential side effect of nausea. SN - 1941-2452 UR - https://www.unboundmedicine.com/medline/citation/22307488/Zinc_and_liver_disease_ L2 - https://doi.org/10.1177/0884533611433534 DB - PRIME DP - Unbound Medicine ER -