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Risk factors for the prognosis of acute kidney injury under the Acute Kidney Injury Network definition: a retrospective, multicenter study in critically ill patients.
Nephrology (Carlton). 2012 May; 17(4):330-7.N

Abstract

AIM

Despite significant advances in medical management and therapeutics, acute kidney injury (AKI) is still a common and serious complication with high morbidity and mortality in hospitalized patients, especially in patients admitted to the intensive care unit (ICU). The primary purpose of this study is to apply the definition proposed by the Acute Kidney Injury Network (AKIN) to investigate the incidence, 28-day mortality and risk factors for the prognosis of AKI in ICU.

METHODS

In this retrospective study, data from a cohort of 4642 patients admitted to five ICUs were analyzed. Univariate and multivariate analyses were performed to investigate the risk factors for prognosis of AKI.

RESULTS

A total of 1036 patients were enrolled. AKI occurred in 353 of them (34.1%) under the AKIN criteria and the mortality was 54.4%. Multivariable analysis showed that variables related to the prognosis of AKI were: four or more (≥4) organ failed systems (odds ratio (OR) = 25.612), AKI III (OR = 14.441), AKI II (OR = 4.491), mechanical ventilation (OR = 7.201), sepsis (OR = 4.552), severe acute pancreatitis (OR = 3.299), base serum creatinine (OR = 1.004) and the length of stay in ICU (OR = 1.050).

CONCLUSIONS

For critically ill patient, the ICU mortality of AKI was correlated with various independent risk factors, especially AKI II, AKI III, severe acute pancreatitis and multiple organ failed systems.

Authors+Show Affiliations

Department of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22309622

Citation

Zhou, Jiaojiao, et al. "Risk Factors for the Prognosis of Acute Kidney Injury Under the Acute Kidney Injury Network Definition: a Retrospective, Multicenter Study in Critically Ill Patients." Nephrology (Carlton, Vic.), vol. 17, no. 4, 2012, pp. 330-7.
Zhou J, Yang L, Zhang K, et al. Risk factors for the prognosis of acute kidney injury under the Acute Kidney Injury Network definition: a retrospective, multicenter study in critically ill patients. Nephrology (Carlton). 2012;17(4):330-7.
Zhou, J., Yang, L., Zhang, K., Liu, Y., & Fu, P. (2012). Risk factors for the prognosis of acute kidney injury under the Acute Kidney Injury Network definition: a retrospective, multicenter study in critically ill patients. Nephrology (Carlton, Vic.), 17(4), 330-7. https://doi.org/10.1111/j.1440-1797.2012.01577.x
Zhou J, et al. Risk Factors for the Prognosis of Acute Kidney Injury Under the Acute Kidney Injury Network Definition: a Retrospective, Multicenter Study in Critically Ill Patients. Nephrology (Carlton). 2012;17(4):330-7. PubMed PMID: 22309622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for the prognosis of acute kidney injury under the Acute Kidney Injury Network definition: a retrospective, multicenter study in critically ill patients. AU - Zhou,Jiaojiao, AU - Yang,Lichuan, AU - Zhang,Kangyi, AU - Liu,Yun, AU - Fu,Ping, PY - 2012/2/8/entrez PY - 2012/2/9/pubmed PY - 2012/8/14/medline SP - 330 EP - 7 JF - Nephrology (Carlton, Vic.) JO - Nephrology (Carlton) VL - 17 IS - 4 N2 - AIM: Despite significant advances in medical management and therapeutics, acute kidney injury (AKI) is still a common and serious complication with high morbidity and mortality in hospitalized patients, especially in patients admitted to the intensive care unit (ICU). The primary purpose of this study is to apply the definition proposed by the Acute Kidney Injury Network (AKIN) to investigate the incidence, 28-day mortality and risk factors for the prognosis of AKI in ICU. METHODS: In this retrospective study, data from a cohort of 4642 patients admitted to five ICUs were analyzed. Univariate and multivariate analyses were performed to investigate the risk factors for prognosis of AKI. RESULTS: A total of 1036 patients were enrolled. AKI occurred in 353 of them (34.1%) under the AKIN criteria and the mortality was 54.4%. Multivariable analysis showed that variables related to the prognosis of AKI were: four or more (≥4) organ failed systems (odds ratio (OR) = 25.612), AKI III (OR = 14.441), AKI II (OR = 4.491), mechanical ventilation (OR = 7.201), sepsis (OR = 4.552), severe acute pancreatitis (OR = 3.299), base serum creatinine (OR = 1.004) and the length of stay in ICU (OR = 1.050). CONCLUSIONS: For critically ill patient, the ICU mortality of AKI was correlated with various independent risk factors, especially AKI II, AKI III, severe acute pancreatitis and multiple organ failed systems. SN - 1440-1797 UR - https://www.unboundmedicine.com/medline/citation/22309622/Risk_factors_for_the_prognosis_of_acute_kidney_injury_under_the_Acute_Kidney_Injury_Network_definition:_a_retrospective_multicenter_study_in_critically_ill_patients_ L2 - https://doi.org/10.1111/j.1440-1797.2012.01577.x DB - PRIME DP - Unbound Medicine ER -