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Microbicides: a new hope for HIV prevention.
Indian J Med Res. 2011 Dec; 134(6):939-49.IJ

Abstract

Human immunodeficiency virus (HIV), causative agent of acquired immunodeficiency syndrome (AIDS), is a global health concern. To control its transmission, safe sex has been proposed as one of the strategies. Microbicides- intravaginal/intrarectal topical formulations of anti-HIV agents have also been proposed to prevent HIV transmission. Microbicides would provide protection by directly inactivating HIV or preventing the attachment, entry or replication of HIV in susceptible target cells as well as their dissemination from target cells present in semen or the host cells lining the vaginal/rectal wall to other migratory cells. Microbicides must be safe, effective following vaginal or rectal administration, and should cause minimal or no genital symptoms or inflammations following long-term repeated usage. However, a safe and efficacious anti-HIV microbicide is not yet available despite the fact that more than 60 candidate agents have been identified to have in vitro activity against HIV, several of which have advanced to clinical testing. Nonetheless, proof-of-concept of microbicides has been established based on the results of recent CAPRISA 004 clinical trials. In this article, the trends and challenges in the development of effective and safe microbicides to combat HIV transmission are reviewed.

Authors+Show Affiliations

Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg,New Delhi, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22310826

Citation

Nutan, and Satish K. Gupta. "Microbicides: a New Hope for HIV Prevention." The Indian Journal of Medical Research, vol. 134, no. 6, 2011, pp. 939-49.
Nutan, Gupta SK. Microbicides: a new hope for HIV prevention. Indian J Med Res. 2011;134(6):939-49.
Gupta, S. K. (2011). Microbicides: a new hope for HIV prevention. The Indian Journal of Medical Research, 134(6), 939-49. https://doi.org/10.4103/0971-5916.92639
Nutan, Gupta SK. Microbicides: a New Hope for HIV Prevention. Indian J Med Res. 2011;134(6):939-49. PubMed PMID: 22310826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbicides: a new hope for HIV prevention. AU - ,, AU - Gupta,Satish K, PY - 2012/2/8/entrez PY - 2012/2/9/pubmed PY - 2012/6/8/medline SP - 939 EP - 49 JF - The Indian journal of medical research JO - Indian J Med Res VL - 134 IS - 6 N2 - Human immunodeficiency virus (HIV), causative agent of acquired immunodeficiency syndrome (AIDS), is a global health concern. To control its transmission, safe sex has been proposed as one of the strategies. Microbicides- intravaginal/intrarectal topical formulations of anti-HIV agents have also been proposed to prevent HIV transmission. Microbicides would provide protection by directly inactivating HIV or preventing the attachment, entry or replication of HIV in susceptible target cells as well as their dissemination from target cells present in semen or the host cells lining the vaginal/rectal wall to other migratory cells. Microbicides must be safe, effective following vaginal or rectal administration, and should cause minimal or no genital symptoms or inflammations following long-term repeated usage. However, a safe and efficacious anti-HIV microbicide is not yet available despite the fact that more than 60 candidate agents have been identified to have in vitro activity against HIV, several of which have advanced to clinical testing. Nonetheless, proof-of-concept of microbicides has been established based on the results of recent CAPRISA 004 clinical trials. In this article, the trends and challenges in the development of effective and safe microbicides to combat HIV transmission are reviewed. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/22310826/Microbicides:_a_new_hope_for_HIV_prevention_ L2 - http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2011;volume=134;issue=6;spage=939;epage=949;aulast=Nutan, DB - PRIME DP - Unbound Medicine ER -