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Human coronavirus NL63 in children: epidemiology, disease spectrum, and genetic diversity.
Hong Kong Med J. 2012 Feb; 18 Suppl 2:27-30.HK

Abstract

1. Human coronaviruses (HCoVs)were detected in 2.5% of 2982 local children hospitalised for acute respiratory infections in 2005 to 2007. 2. Using the 'pancoronavirus' reverse transcription-polymerase chain reaction assay, detection rates were 0.6% for HCoVNL63,1.2% for HCoV-OC43,0.5% for HCoV-HKU1, and 0.2% for HCoV-229E. Notably, HCoV-NL63 infections were significantly more common among children hospitalised in 2006/2007 (1.2%) than in 2005/2006 (0.3%).3. The peak season for HCoVNL63 infection was autumn(September to October). 4. HCoV-NL63 infection was associated with younger age,croup, febrile convulsion, and acute gastroenteritis. Such disease associations were not found with the other three HCoVs. 5. Most local HCoV-NL63 isolates were closely related to the prototype strain in Netherlands(NL496), but a few were phylogenetically distinct from the major cluster.

Authors+Show Affiliations

Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22311358

Citation

Leung, T F., et al. "Human Coronavirus NL63 in Children: Epidemiology, Disease Spectrum, and Genetic Diversity." Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, vol. 18 Suppl 2, 2012, pp. 27-30.
Leung TF, Chan PK, Wong WK, et al. Human coronavirus NL63 in children: epidemiology, disease spectrum, and genetic diversity. Hong Kong Med J. 2012;18 Suppl 2:27-30.
Leung, T. F., Chan, P. K., Wong, W. K., Ip, M., Cheng, W. T., & Ng, P. C. (2012). Human coronavirus NL63 in children: epidemiology, disease spectrum, and genetic diversity. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 18 Suppl 2, 27-30.
Leung TF, et al. Human Coronavirus NL63 in Children: Epidemiology, Disease Spectrum, and Genetic Diversity. Hong Kong Med J. 2012;18 Suppl 2:27-30. PubMed PMID: 22311358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human coronavirus NL63 in children: epidemiology, disease spectrum, and genetic diversity. AU - Leung,T F, AU - Chan,P K S, AU - Wong,W K G, AU - Ip,M, AU - Cheng,W T F, AU - Ng,P C, PY - 2012/2/8/entrez PY - 2012/2/15/pubmed PY - 2012/5/31/medline SP - 27 EP - 30 JF - Hong Kong medical journal = Xianggang yi xue za zhi JO - Hong Kong Med J VL - 18 Suppl 2 N2 - 1. Human coronaviruses (HCoVs)were detected in 2.5% of 2982 local children hospitalised for acute respiratory infections in 2005 to 2007. 2. Using the 'pancoronavirus' reverse transcription-polymerase chain reaction assay, detection rates were 0.6% for HCoVNL63,1.2% for HCoV-OC43,0.5% for HCoV-HKU1, and 0.2% for HCoV-229E. Notably, HCoV-NL63 infections were significantly more common among children hospitalised in 2006/2007 (1.2%) than in 2005/2006 (0.3%).3. The peak season for HCoVNL63 infection was autumn(September to October). 4. HCoV-NL63 infection was associated with younger age,croup, febrile convulsion, and acute gastroenteritis. Such disease associations were not found with the other three HCoVs. 5. Most local HCoV-NL63 isolates were closely related to the prototype strain in Netherlands(NL496), but a few were phylogenetically distinct from the major cluster. SN - 1024-2708 UR - https://www.unboundmedicine.com/medline/citation/22311358/Human_coronavirus_NL63_in_children:_epidemiology_disease_spectrum_and_genetic_diversity_ L2 - http://www.hkmj.org/abstracts/v18n1s2/27.htm DB - PRIME DP - Unbound Medicine ER -