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Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes.
Diabetologia. 2012 May; 55(5):1417-23.D

Abstract

AIMS/HYPOTHESIS

Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to the OGTT. The purpose of this study was to determine whether short-term exercise training improves PPG and glycaemic control in free-living patients with type 2 diabetes, independently of the changes in fitness, adiposity and energy balance often associated with chronic exercise training.

METHODS

Using continuous glucose monitors, PPG was quantified in previously sedentary patients with type 2 diabetes not using exogenous insulin (n = 13, age 53 ± 2 years, HbA(1c) 6.6 ± 0.2% (49.1 ± 1.9 mmol/mol)) during 3 days of habitual activity and during the final 3 days of a 7 day aerobic exercise training programme (7D-EX) which does not elicit measurable changes in cardiorespiratory fitness or body composition. Diet was standardised across monitoring periods, with modifications during 7D-EX to offset increases in energy expenditure. OGTTs were performed on the morning following each monitoring period.

RESULTS

7D-EX attenuated PPG (p < 0.05) as well as the frequency, magnitude and duration of glycaemic excursions (p < 0.05). Conversely, average 24 h blood glucose did not change, nor did glucose, insulin or C-peptide responses to the OGTT.

CONCLUSIONS/INTERPRETATION

7D-EX attenuated glycaemic variability and PPG in free-living patients with type 2 diabetes but did not significantly alter responses to the laboratory-based OGTT. These effects appeared to be independent of changes in fitness, body composition or energy balance. ClinicalTrials.gov numbers: NCT00954109 and NCT00972452.

FUNDING

This project was funded by the University of Missouri Institute for Clinical and Translational Sciences (CRM), NIH grant T32 AR-048523 (CRM), Diabetes Action Research and Education Foundation (JPT). Medtronic supplied CGMS sensors at a discounted rate.

Authors+Show Affiliations

Department of Nutrition and Exercise Physiology, 10A McKee, University of Missouri, Columbia, MO, 65211, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22311420

Citation

Mikus, C R., et al. "Glycaemic Control Is Improved By 7 Days of Aerobic Exercise Training in Patients With Type 2 Diabetes." Diabetologia, vol. 55, no. 5, 2012, pp. 1417-23.
Mikus CR, Oberlin DJ, Libla J, et al. Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes. Diabetologia. 2012;55(5):1417-23.
Mikus, C. R., Oberlin, D. J., Libla, J., Boyle, L. J., & Thyfault, J. P. (2012). Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes. Diabetologia, 55(5), 1417-23. https://doi.org/10.1007/s00125-012-2490-8
Mikus CR, et al. Glycaemic Control Is Improved By 7 Days of Aerobic Exercise Training in Patients With Type 2 Diabetes. Diabetologia. 2012;55(5):1417-23. PubMed PMID: 22311420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes. AU - Mikus,C R, AU - Oberlin,D J, AU - Libla,J, AU - Boyle,L J, AU - Thyfault,J P, Y1 - 2012/02/04/ PY - 2011/12/10/received PY - 2012/01/09/accepted PY - 2012/2/8/entrez PY - 2012/2/9/pubmed PY - 2012/8/25/medline SP - 1417 EP - 23 JF - Diabetologia JO - Diabetologia VL - 55 IS - 5 N2 - AIMS/HYPOTHESIS: Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to the OGTT. The purpose of this study was to determine whether short-term exercise training improves PPG and glycaemic control in free-living patients with type 2 diabetes, independently of the changes in fitness, adiposity and energy balance often associated with chronic exercise training. METHODS: Using continuous glucose monitors, PPG was quantified in previously sedentary patients with type 2 diabetes not using exogenous insulin (n = 13, age 53 ± 2 years, HbA(1c) 6.6 ± 0.2% (49.1 ± 1.9 mmol/mol)) during 3 days of habitual activity and during the final 3 days of a 7 day aerobic exercise training programme (7D-EX) which does not elicit measurable changes in cardiorespiratory fitness or body composition. Diet was standardised across monitoring periods, with modifications during 7D-EX to offset increases in energy expenditure. OGTTs were performed on the morning following each monitoring period. RESULTS: 7D-EX attenuated PPG (p < 0.05) as well as the frequency, magnitude and duration of glycaemic excursions (p < 0.05). Conversely, average 24 h blood glucose did not change, nor did glucose, insulin or C-peptide responses to the OGTT. CONCLUSIONS/INTERPRETATION: 7D-EX attenuated glycaemic variability and PPG in free-living patients with type 2 diabetes but did not significantly alter responses to the laboratory-based OGTT. These effects appeared to be independent of changes in fitness, body composition or energy balance. ClinicalTrials.gov numbers: NCT00954109 and NCT00972452. FUNDING: This project was funded by the University of Missouri Institute for Clinical and Translational Sciences (CRM), NIH grant T32 AR-048523 (CRM), Diabetes Action Research and Education Foundation (JPT). Medtronic supplied CGMS sensors at a discounted rate. SN - 1432-0428 UR - https://www.unboundmedicine.com/medline/citation/22311420/Glycaemic_control_is_improved_by_7_days_of_aerobic_exercise_training_in_patients_with_type_2_diabetes_ L2 - https://doi.org/10.1007/s00125-012-2490-8 DB - PRIME DP - Unbound Medicine ER -