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Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes.
Diabetologia 2012; 55(5):1417-23D

Abstract

AIMS/HYPOTHESIS

Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to the OGTT. The purpose of this study was to determine whether short-term exercise training improves PPG and glycaemic control in free-living patients with type 2 diabetes, independently of the changes in fitness, adiposity and energy balance often associated with chronic exercise training.

METHODS

Using continuous glucose monitors, PPG was quantified in previously sedentary patients with type 2 diabetes not using exogenous insulin (n = 13, age 53 ± 2 years, HbA(1c) 6.6 ± 0.2% (49.1 ± 1.9 mmol/mol)) during 3 days of habitual activity and during the final 3 days of a 7 day aerobic exercise training programme (7D-EX) which does not elicit measurable changes in cardiorespiratory fitness or body composition. Diet was standardised across monitoring periods, with modifications during 7D-EX to offset increases in energy expenditure. OGTTs were performed on the morning following each monitoring period.

RESULTS

7D-EX attenuated PPG (p < 0.05) as well as the frequency, magnitude and duration of glycaemic excursions (p < 0.05). Conversely, average 24 h blood glucose did not change, nor did glucose, insulin or C-peptide responses to the OGTT.

CONCLUSIONS/INTERPRETATION

7D-EX attenuated glycaemic variability and PPG in free-living patients with type 2 diabetes but did not significantly alter responses to the laboratory-based OGTT. These effects appeared to be independent of changes in fitness, body composition or energy balance. ClinicalTrials.gov numbers: NCT00954109 and NCT00972452.

FUNDING

This project was funded by the University of Missouri Institute for Clinical and Translational Sciences (CRM), NIH grant T32 AR-048523 (CRM), Diabetes Action Research and Education Foundation (JPT). Medtronic supplied CGMS sensors at a discounted rate.

Authors+Show Affiliations

Department of Nutrition and Exercise Physiology, 10A McKee, University of Missouri, Columbia, MO, 65211, USA.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22311420

Citation

Mikus, C R., et al. "Glycaemic Control Is Improved By 7 Days of Aerobic Exercise Training in Patients With Type 2 Diabetes." Diabetologia, vol. 55, no. 5, 2012, pp. 1417-23.
Mikus CR, Oberlin DJ, Libla J, et al. Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes. Diabetologia. 2012;55(5):1417-23.
Mikus, C. R., Oberlin, D. J., Libla, J., Boyle, L. J., & Thyfault, J. P. (2012). Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes. Diabetologia, 55(5), pp. 1417-23. doi:10.1007/s00125-012-2490-8.
Mikus CR, et al. Glycaemic Control Is Improved By 7 Days of Aerobic Exercise Training in Patients With Type 2 Diabetes. Diabetologia. 2012;55(5):1417-23. PubMed PMID: 22311420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes. AU - Mikus,C R, AU - Oberlin,D J, AU - Libla,J, AU - Boyle,L J, AU - Thyfault,J P, Y1 - 2012/02/04/ PY - 2011/12/10/received PY - 2012/01/09/accepted PY - 2012/2/8/entrez PY - 2012/2/9/pubmed PY - 2012/8/25/medline SP - 1417 EP - 23 JF - Diabetologia JO - Diabetologia VL - 55 IS - 5 N2 - AIMS/HYPOTHESIS: Cardiovascular events and death are better predicted by postprandial glucose (PPG) than by fasting blood glucose or HbA(1c). While chronic exercise reduces HbA(1c) in patients with type 2 diabetes, short-term exercise improves measures of insulin sensitivity but does not consistently alter responses to the OGTT. The purpose of this study was to determine whether short-term exercise training improves PPG and glycaemic control in free-living patients with type 2 diabetes, independently of the changes in fitness, adiposity and energy balance often associated with chronic exercise training. METHODS: Using continuous glucose monitors, PPG was quantified in previously sedentary patients with type 2 diabetes not using exogenous insulin (n = 13, age 53 ± 2 years, HbA(1c) 6.6 ± 0.2% (49.1 ± 1.9 mmol/mol)) during 3 days of habitual activity and during the final 3 days of a 7 day aerobic exercise training programme (7D-EX) which does not elicit measurable changes in cardiorespiratory fitness or body composition. Diet was standardised across monitoring periods, with modifications during 7D-EX to offset increases in energy expenditure. OGTTs were performed on the morning following each monitoring period. RESULTS: 7D-EX attenuated PPG (p < 0.05) as well as the frequency, magnitude and duration of glycaemic excursions (p < 0.05). Conversely, average 24 h blood glucose did not change, nor did glucose, insulin or C-peptide responses to the OGTT. CONCLUSIONS/INTERPRETATION: 7D-EX attenuated glycaemic variability and PPG in free-living patients with type 2 diabetes but did not significantly alter responses to the laboratory-based OGTT. These effects appeared to be independent of changes in fitness, body composition or energy balance. ClinicalTrials.gov numbers: NCT00954109 and NCT00972452. FUNDING: This project was funded by the University of Missouri Institute for Clinical and Translational Sciences (CRM), NIH grant T32 AR-048523 (CRM), Diabetes Action Research and Education Foundation (JPT). Medtronic supplied CGMS sensors at a discounted rate. SN - 1432-0428 UR - https://www.unboundmedicine.com/medline/citation/22311420/Glycaemic_control_is_improved_by_7_days_of_aerobic_exercise_training_in_patients_with_type_2_diabetes_ L2 - https://dx.doi.org/10.1007/s00125-012-2490-8 DB - PRIME DP - Unbound Medicine ER -