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Pathology of demyelinating diseases.
Annu Rev Pathol. 2012; 7:185-217.AR

Abstract

There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases. Neuropathological studies have provided fundamental new insights into the pathogenesis of these disorders and have led to major advances in our understanding of multiple sclerosis (MS) heterogeneity, the substrate of irreversible progressive disability in MS, the relationship between inflammation and neurodegeneration in MS, the neuroimaging correlates of MS lesions, and the pathogenesis of other central nervous system inflammatory disorders, including neuromyelitis optica, acute disseminated encephalomyelitis, and Balo's concentric sclerosis. Herein, we review the pathological features of these central nervous system inflammatory demyelinating disorders and discuss neuropathological studies that have yielded novel insights into potential mechanisms involved in the formation of the demyelinated lesion.

Authors+Show Affiliations

Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, Saskatchewan S7K 0M7, Canada. bogdan.popescu@usask.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22313379

Citation

Popescu, Bogdan F Gh, and Claudia F. Lucchinetti. "Pathology of Demyelinating Diseases." Annual Review of Pathology, vol. 7, 2012, pp. 185-217.
Popescu BF, Lucchinetti CF. Pathology of demyelinating diseases. Annu Rev Pathol. 2012;7:185-217.
Popescu, B. F., & Lucchinetti, C. F. (2012). Pathology of demyelinating diseases. Annual Review of Pathology, 7, 185-217. https://doi.org/10.1146/annurev-pathol-011811-132443
Popescu BF, Lucchinetti CF. Pathology of Demyelinating Diseases. Annu Rev Pathol. 2012;7:185-217. PubMed PMID: 22313379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathology of demyelinating diseases. AU - Popescu,Bogdan F Gh, AU - Lucchinetti,Claudia F, PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2013/4/13/medline SP - 185 EP - 217 JF - Annual review of pathology JO - Annu Rev Pathol VL - 7 N2 - There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases. Neuropathological studies have provided fundamental new insights into the pathogenesis of these disorders and have led to major advances in our understanding of multiple sclerosis (MS) heterogeneity, the substrate of irreversible progressive disability in MS, the relationship between inflammation and neurodegeneration in MS, the neuroimaging correlates of MS lesions, and the pathogenesis of other central nervous system inflammatory disorders, including neuromyelitis optica, acute disseminated encephalomyelitis, and Balo's concentric sclerosis. Herein, we review the pathological features of these central nervous system inflammatory demyelinating disorders and discuss neuropathological studies that have yielded novel insights into potential mechanisms involved in the formation of the demyelinated lesion. SN - 1553-4014 UR - https://www.unboundmedicine.com/medline/citation/22313379/Pathology_of_demyelinating_diseases_ L2 - http://arjournals.annualreviews.org/doi/full/10.1146/annurev-pathol-011811-132443?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -