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The effect of maternal fish oil supplementation during the last trimester of pregnancy on blood pressure, heart rate and heart rate variability in the 19-year-old offspring.
Br J Nutr 2012; 108(8):1475-83BJ

Abstract

Studies in experimental animals and human subjects have suggested that intake of n-3 fatty acids in early life can affect cardiovascular risk factors in adult life. Therefore, the aim of the present study was to investigate the effect of fish oil (FO) supplementation during the third trimester of pregnancy on blood pressure (BP), heart rate (HR) and HR variability (HRV) in the 19-year-old offspring. The study was based on follow-up of a randomised, controlled trial from 1990, in which 533 pregnant women were randomised to FO, olive oil (OO) or no oil (NO) during the last trimester of pregnancy. The offspring was invited to a physical examination including BP, HR and HRV measurements. A subgroup consisting of the offspring of mothers with a low baseline fish intake also had 24 h HRV determined. The OO group was used as reference and multiple linear regression modelling was used to compare the FO and OO groups. A total of 180 of the offspring from the FO and OO groups agreed to participate in the study (45%). The adjusted difference between the FO and OO groups was 2 (95% CI -1, 4) mmHg in systolic and 1 (95% CI 0, 3) mmHg in diastolic BP. The difference in HR was 1 (95% CI -2, 4). Also, HRV indices did not differ significantly between groups. Hence, FO supplementation during late pregnancy was not associated with offspring BP, HR and HRV during adolescence.

Authors+Show Affiliations

Section for Epidemiology, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000 Aarhus C, Denmark. dr@soci.au.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22313729

Citation

Rytter, Dorte, et al. "The Effect of Maternal Fish Oil Supplementation During the Last Trimester of Pregnancy On Blood Pressure, Heart Rate and Heart Rate Variability in the 19-year-old Offspring." The British Journal of Nutrition, vol. 108, no. 8, 2012, pp. 1475-83.
Rytter D, Christensen JH, Bech BH, et al. The effect of maternal fish oil supplementation during the last trimester of pregnancy on blood pressure, heart rate and heart rate variability in the 19-year-old offspring. Br J Nutr. 2012;108(8):1475-83.
Rytter, D., Christensen, J. H., Bech, B. H., Schmidt, E. B., Henriksen, T. B., & Olsen, S. F. (2012). The effect of maternal fish oil supplementation during the last trimester of pregnancy on blood pressure, heart rate and heart rate variability in the 19-year-old offspring. The British Journal of Nutrition, 108(8), pp. 1475-83. doi:10.1017/S0007114511006799.
Rytter D, et al. The Effect of Maternal Fish Oil Supplementation During the Last Trimester of Pregnancy On Blood Pressure, Heart Rate and Heart Rate Variability in the 19-year-old Offspring. Br J Nutr. 2012 Oct 28;108(8):1475-83. PubMed PMID: 22313729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of maternal fish oil supplementation during the last trimester of pregnancy on blood pressure, heart rate and heart rate variability in the 19-year-old offspring. AU - Rytter,Dorte, AU - Christensen,Jeppe H, AU - Bech,Bodil H, AU - Schmidt,Erik B, AU - Henriksen,Tine B, AU - Olsen,Sjurdur F, Y1 - 2012/02/07/ PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2012/12/27/medline SP - 1475 EP - 83 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 108 IS - 8 N2 - Studies in experimental animals and human subjects have suggested that intake of n-3 fatty acids in early life can affect cardiovascular risk factors in adult life. Therefore, the aim of the present study was to investigate the effect of fish oil (FO) supplementation during the third trimester of pregnancy on blood pressure (BP), heart rate (HR) and HR variability (HRV) in the 19-year-old offspring. The study was based on follow-up of a randomised, controlled trial from 1990, in which 533 pregnant women were randomised to FO, olive oil (OO) or no oil (NO) during the last trimester of pregnancy. The offspring was invited to a physical examination including BP, HR and HRV measurements. A subgroup consisting of the offspring of mothers with a low baseline fish intake also had 24 h HRV determined. The OO group was used as reference and multiple linear regression modelling was used to compare the FO and OO groups. A total of 180 of the offspring from the FO and OO groups agreed to participate in the study (45%). The adjusted difference between the FO and OO groups was 2 (95% CI -1, 4) mmHg in systolic and 1 (95% CI 0, 3) mmHg in diastolic BP. The difference in HR was 1 (95% CI -2, 4). Also, HRV indices did not differ significantly between groups. Hence, FO supplementation during late pregnancy was not associated with offspring BP, HR and HRV during adolescence. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/22313729/The_effect_of_maternal_fish_oil_supplementation_during_the_last_trimester_of_pregnancy_on_blood_pressure_heart_rate_and_heart_rate_variability_in_the_19_year_old_offspring_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511006799/type/journal_article DB - PRIME DP - Unbound Medicine ER -