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Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries.
Eur J Pharmacol. 2012 Apr 05; 680(1-3):73-80.EJ

Abstract

A previous report showed that histamine in denuded mesenteric vascular beds produced a triphasic response; an initial small histamine H(2) receptor-mediated vasodilation, a transient histamine H(1) receptor-mediated vasoconstriction, and finally a long-lasting vasodilation. We further investigated the vascular effect of histamine in mesenteric preparations without an endothelium to clarify the possible involvement of perivascular nerves. Male Wistar rat mesenteric vascular beds without an endothelium were perfused with Krebs solution containing methoxamine to produce active tone and lafutidine to block histamine H(2) receptor-mediated vasodilation. Histamine (1-100μM) was perfused for 1min and perfusion pressure was measured with a pressure transducer. Histamine caused a biphasic vascular response; initial vasoconstriction followed vasodilation. Tetrodotoxin (a neurotoxin, 1μM) and procaine (a local anesthetic, 100μM) significantly inhibited the vasoconstriction and vasodilation. Ruthenium red (a transient receptor potential vanilloid 1 (TRPV1) antagonist, 1μM) also significantly inhibited both phases of the response. Pretreatment with capsaicin (a depletor of calcitonin gene-related peptide (CGRP)-containing nerves, 5μM) significantly inhibited the vasodilation without affecting the initial vasoconstriction. Both indomethacin (a cyclooxygenase inhibitor, 0.5μM) and seratrodast (a thromboxane A(2) receptor antagonist, 0.1μM) abolished the histamine-induced vasoconstriction and subsequent vasodilation. These results suggest that histamine-induced vasoconstriction and long-lasting vasodilation are mediated by activation of TRPV1 on capsaicin-sensitive and capsaicin-insensitive nerves. They also suggest that perivascular nerves and prostanoids, probably thromboxane A(2), are responsible for the vascular response to histamine.

Authors+Show Affiliations

Department of Clinical Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22314222

Citation

Jin, Honghua, et al. "Involvement of Perivascular Nerves and Transient Receptor Potential Vanilloid 1 (TRPV1) in Vascular Responses to Histamine in Rat Mesenteric Resistance Arteries." European Journal of Pharmacology, vol. 680, no. 1-3, 2012, pp. 73-80.
Jin H, Sun P, Takatori S, et al. Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries. Eur J Pharmacol. 2012;680(1-3):73-80.
Jin, H., Sun, P., Takatori, S., Koyama, T., Zamami, Y., Tangsucharit, P., Kitamura, Y., & Kawasaki, H. (2012). Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries. European Journal of Pharmacology, 680(1-3), 73-80. https://doi.org/10.1016/j.ejphar.2012.01.018
Jin H, et al. Involvement of Perivascular Nerves and Transient Receptor Potential Vanilloid 1 (TRPV1) in Vascular Responses to Histamine in Rat Mesenteric Resistance Arteries. Eur J Pharmacol. 2012 Apr 5;680(1-3):73-80. PubMed PMID: 22314222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries. AU - Jin,Honghua, AU - Sun,Pengyuan, AU - Takatori,Shingo, AU - Koyama,Toshihiro, AU - Zamami,Yoshito, AU - Tangsucharit,Panot, AU - Kitamura,Yoshihisa, AU - Kawasaki,Hiromu, Y1 - 2012/01/31/ PY - 2011/08/04/received PY - 2012/01/16/revised PY - 2012/01/23/accepted PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2012/9/14/medline SP - 73 EP - 80 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 680 IS - 1-3 N2 - A previous report showed that histamine in denuded mesenteric vascular beds produced a triphasic response; an initial small histamine H(2) receptor-mediated vasodilation, a transient histamine H(1) receptor-mediated vasoconstriction, and finally a long-lasting vasodilation. We further investigated the vascular effect of histamine in mesenteric preparations without an endothelium to clarify the possible involvement of perivascular nerves. Male Wistar rat mesenteric vascular beds without an endothelium were perfused with Krebs solution containing methoxamine to produce active tone and lafutidine to block histamine H(2) receptor-mediated vasodilation. Histamine (1-100μM) was perfused for 1min and perfusion pressure was measured with a pressure transducer. Histamine caused a biphasic vascular response; initial vasoconstriction followed vasodilation. Tetrodotoxin (a neurotoxin, 1μM) and procaine (a local anesthetic, 100μM) significantly inhibited the vasoconstriction and vasodilation. Ruthenium red (a transient receptor potential vanilloid 1 (TRPV1) antagonist, 1μM) also significantly inhibited both phases of the response. Pretreatment with capsaicin (a depletor of calcitonin gene-related peptide (CGRP)-containing nerves, 5μM) significantly inhibited the vasodilation without affecting the initial vasoconstriction. Both indomethacin (a cyclooxygenase inhibitor, 0.5μM) and seratrodast (a thromboxane A(2) receptor antagonist, 0.1μM) abolished the histamine-induced vasoconstriction and subsequent vasodilation. These results suggest that histamine-induced vasoconstriction and long-lasting vasodilation are mediated by activation of TRPV1 on capsaicin-sensitive and capsaicin-insensitive nerves. They also suggest that perivascular nerves and prostanoids, probably thromboxane A(2), are responsible for the vascular response to histamine. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/22314222/Involvement_of_perivascular_nerves_and_transient_receptor_potential_vanilloid_1__TRPV1__in_vascular_responses_to_histamine_in_rat_mesenteric_resistance_arteries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(12)00069-6 DB - PRIME DP - Unbound Medicine ER -