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Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice.
Neuroscience. 2012 Apr 05; 207:283-7.N

Abstract

In the present study, the effect of medroxyprogesterone (MPA) is evaluated for its effect on pentylenetetrazole (PTZ) kindling model of epileptogenesis in mice followed by evaluation on kindling-induced changes in cognitive and motor functions. To explore whether the effects are mediated via progesterone receptors, a selective antagonist of progesterone (mifepristone, MIF) was also taken. Kindling was induced by once every 2 days treatment with PTZ (25 mg/kg, i.p.) for 5 weeks. The seizure severity during induction of kindling and % incidence of animals kindled at the end of 5 weeks were recorded. The motor function was assessed using a grip strength meter, whereas spatial memory was assessed in a cross maze. MPA (5 and 10 mg/kg, i.p.) significantly reduced the seizure severity scores and produced a significant decrease in the incidence of animals kindled at the end of 5 weeks (P<0.01). A higher efficacy was observed against male mice as compared with females following MPA. MIF neither reduced nor delayed the development of PTZ-induced kindling in mice. Also, it couldn't reverse the antiepileptogenic effects of MPA. On grip strength test (GST) and spontaneous alternation behavior (SAB), a significant decline in GST and % alternation was observed in kindled mice which was reversed by pre-treatment with MPA. MIF, however, could reverse only the reduced % alternation and not grip strength (GS) in PTZ-kindled animals. The study shows that MPA has antiepileptogenic effects against development of PTZ-induced kindling in mice that may not be mediated via progesterone receptors.

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Authors+Show Affiliations

Nasir SA
Neurobehavioral Pharmacology Laboratory, Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
Sharma A
No affiliation info available
Khanam R
No affiliation info available
Vohora D
No affiliation info available

MeSH

AnimalsAnticonvulsantsContraceptives, Oral, SyntheticConvulsantsDisease Models, AnimalEpilepsyFemaleKindling, NeurologicMaleMedroxyprogesteroneMicePentylenetetrazoleReceptors, Progesterone

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22314318

Citation

Nasir, S A., et al. "Effect of Medroxyprogesterone On Development of Pentylenetetrazole-induced Kindling in Mice." Neuroscience, vol. 207, 2012, pp. 283-7.
Nasir SA, Sharma A, Khanam R, et al. Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice. Neuroscience. 2012;207:283-7.
Nasir, S. A., Sharma, A., Khanam, R., & Vohora, D. (2012). Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice. Neuroscience, 207, 283-7. https://doi.org/10.1016/j.neuroscience.2012.01.031
Nasir SA, et al. Effect of Medroxyprogesterone On Development of Pentylenetetrazole-induced Kindling in Mice. Neuroscience. 2012 Apr 5;207:283-7. PubMed PMID: 22314318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice. AU - Nasir,S A, AU - Sharma,A, AU - Khanam,R, AU - Vohora,D, Y1 - 2012/01/25/ PY - 2011/09/07/received PY - 2012/01/13/revised PY - 2012/01/14/accepted PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2012/12/10/medline SP - 283 EP - 7 JF - Neuroscience JO - Neuroscience VL - 207 N2 - In the present study, the effect of medroxyprogesterone (MPA) is evaluated for its effect on pentylenetetrazole (PTZ) kindling model of epileptogenesis in mice followed by evaluation on kindling-induced changes in cognitive and motor functions. To explore whether the effects are mediated via progesterone receptors, a selective antagonist of progesterone (mifepristone, MIF) was also taken. Kindling was induced by once every 2 days treatment with PTZ (25 mg/kg, i.p.) for 5 weeks. The seizure severity during induction of kindling and % incidence of animals kindled at the end of 5 weeks were recorded. The motor function was assessed using a grip strength meter, whereas spatial memory was assessed in a cross maze. MPA (5 and 10 mg/kg, i.p.) significantly reduced the seizure severity scores and produced a significant decrease in the incidence of animals kindled at the end of 5 weeks (P<0.01). A higher efficacy was observed against male mice as compared with females following MPA. MIF neither reduced nor delayed the development of PTZ-induced kindling in mice. Also, it couldn't reverse the antiepileptogenic effects of MPA. On grip strength test (GST) and spontaneous alternation behavior (SAB), a significant decline in GST and % alternation was observed in kindled mice which was reversed by pre-treatment with MPA. MIF, however, could reverse only the reduced % alternation and not grip strength (GS) in PTZ-kindled animals. The study shows that MPA has antiepileptogenic effects against development of PTZ-induced kindling in mice that may not be mediated via progesterone receptors. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/22314318/Effect_of_medroxyprogesterone_on_development_of_pentylenetetrazole_induced_kindling_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(12)00053-X DB - PRIME DP - Unbound Medicine ER -