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Visfatin levels in prepubertal children born small or large for gestational age.
Horm Metab Res. 2012 Feb; 44(2):135-9.HM

Abstract

Children born small (SGA) or large (LGA) for gestational age are prone to develop insulin resistance (IR) during childhood. Visfatin, a hormone with insulin-mimetic actions, has been associated with IR. This study was designed to examine whether serum level of visfatin is correlated with metabolic indices of IR, in prepuberty in association with the intrauterine growth pattern. The following parameters were evaluated at a mean age of 6.5±1.2 years in 155 prepubertal children born appropriate for the gestational age (AGA) (n=63), or SGA (n=42), or LGA (n=50): serum levels of visfatin, adiponectin, leptin, fasting glucose (G(F)) and insulin (I(F)), the homeostasis model assessment IR index (HOMA-IR), plasma lipids, anthropometric indices at birth and the time of evaluation, and obesity indices [waist circumference (WC), body mass index (BMI) and skinfold thickness]. The mean serum level of visfatin was lower in the SGA than in the AGA and the LGA children (9±5.2 vs. 11.8±5.1 and 12.7±5.6 ng/ml, respectively, p<0.01). Girls had lower visfatin levels than boys (10.4±4.3 ng/ml vs. 12.5±6.7 ng/ml, p<0.05). Visfatin was not correlated with IR indices. In multiple regression analysis visfatin level was positively correlated with birth weight z-score (t=2.56, beta=0.24, p<0.01) and crown to heel z-score (t=2.46, beta=0.22, p=0.014), independent of age, gender, maternal weight before pregnancy, maternal weight gain during pregnancy, BMI z-score, WC z-score, serum leptin and adiponectin, and HOMA-IR. In conclusion serum visfatin level was lower in prepubertal SGA children but not correlated with IR indices. Low birth weight was an independent predictor of visfatin level.

Authors+Show Affiliations

Neonatal Intensive Care Unit, University of Ioannina, Ioannina, Greece. vgiapros@cc.uoi.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22314334

Citation

Giapros, V I., et al. "Visfatin Levels in Prepubertal Children Born Small or Large for Gestational Age." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 44, no. 2, 2012, pp. 135-9.
Giapros VI, Kiortsis DN, Evagelidou EN, et al. Visfatin levels in prepubertal children born small or large for gestational age. Horm Metab Res. 2012;44(2):135-9.
Giapros, V. I., Kiortsis, D. N., Evagelidou, E. N., Challa, A. S., Cholevas, V. K., Siomou, E. C., Bairaktari, E. T., & Andronikou, S. K. (2012). Visfatin levels in prepubertal children born small or large for gestational age. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 44(2), 135-9. https://doi.org/10.1055/s-0031-1299729
Giapros VI, et al. Visfatin Levels in Prepubertal Children Born Small or Large for Gestational Age. Horm Metab Res. 2012;44(2):135-9. PubMed PMID: 22314334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visfatin levels in prepubertal children born small or large for gestational age. AU - Giapros,V I, AU - Kiortsis,D N, AU - Evagelidou,E N, AU - Challa,A S, AU - Cholevas,V K, AU - Siomou,E C, AU - Bairaktari,E T, AU - Andronikou,S K, Y1 - 2012/01/13/ PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2012/9/12/medline SP - 135 EP - 9 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 44 IS - 2 N2 - Children born small (SGA) or large (LGA) for gestational age are prone to develop insulin resistance (IR) during childhood. Visfatin, a hormone with insulin-mimetic actions, has been associated with IR. This study was designed to examine whether serum level of visfatin is correlated with metabolic indices of IR, in prepuberty in association with the intrauterine growth pattern. The following parameters were evaluated at a mean age of 6.5±1.2 years in 155 prepubertal children born appropriate for the gestational age (AGA) (n=63), or SGA (n=42), or LGA (n=50): serum levels of visfatin, adiponectin, leptin, fasting glucose (G(F)) and insulin (I(F)), the homeostasis model assessment IR index (HOMA-IR), plasma lipids, anthropometric indices at birth and the time of evaluation, and obesity indices [waist circumference (WC), body mass index (BMI) and skinfold thickness]. The mean serum level of visfatin was lower in the SGA than in the AGA and the LGA children (9±5.2 vs. 11.8±5.1 and 12.7±5.6 ng/ml, respectively, p<0.01). Girls had lower visfatin levels than boys (10.4±4.3 ng/ml vs. 12.5±6.7 ng/ml, p<0.05). Visfatin was not correlated with IR indices. In multiple regression analysis visfatin level was positively correlated with birth weight z-score (t=2.56, beta=0.24, p<0.01) and crown to heel z-score (t=2.46, beta=0.22, p=0.014), independent of age, gender, maternal weight before pregnancy, maternal weight gain during pregnancy, BMI z-score, WC z-score, serum leptin and adiponectin, and HOMA-IR. In conclusion serum visfatin level was lower in prepubertal SGA children but not correlated with IR indices. Low birth weight was an independent predictor of visfatin level. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/22314334/Visfatin_levels_in_prepubertal_children_born_small_or_large_for_gestational_age_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1299729 DB - PRIME DP - Unbound Medicine ER -