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Acute Effects of Acu-TENS on FEV1 and Blood Β-endorphin Level in Chronic Obstructive Pulmonary Disease.
Altern Ther Health Med. 2011 Sep-Oct; 17(5):8-13.AT

Abstract

Background Pharmacotherapy is the mainstay of dyspnea management in patients with chronic obstructive pulmonary disease (COPD). Undesirable side effects have led to the application of alternative treatment strategies such as acupuncture. Our previous study showed that transcutaneous electrical nerve stimulation over acupuncture points (Acu-TENS), a noninvasive modality, can reduce dyspnea symptoms in patients with COPD, but the underlying mechanism is unknown. Primary Study Objective This study investigated the effect of acu-TENS on forced expiratory volume in one second (FEV1), dyspnea, and Β-endorphin levels in patients with COPD. Design A double-blinded randomized controlled trial

Setting:

Hospital outpatient clinic Participants Forty-four subjects diagnosed with COPD Intervention Participants were randomly assigned to receive either acu-TENS or placebo-TENS on Dingchuan (EX-B1) for 45 minutes. Outcome Measures FEV1, forced vital capacity (FVC), dyspnea visual analogue score (DVAS), respiratory rate (RR), and blood Β-endorphin levels were measured before and after therapeutic intervention. Results Our findings showed that the increase in FEV1 was 24.2% greater in the acu-TENS group than the placebo group (P < .0001). The decrease in RR and DVAS was also more in the acu-TENS group by 14.2% (P < .0001) and 20.7% (P = .006), respectively. The postintervention increase in Β-endorphin was significantly higher in the acu-TENS than the placebo group (18.3%) (P = .027). Furthermore, the percentage reduction in RR correlated with the increase in Β-endorphin (R = -0.477, P = .033). Conclusion An improvement in FEV1 and dyspnea score at the end of Acu-TENS treatment was associated with a concurrent increase in b-endorphin level in patients with COPD.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22314671

Citation

Jones, Alice Y M., et al. "Acute Effects of Acu-TENS On FEV1 and Blood Β-endorphin Level in Chronic Obstructive Pulmonary Disease." Alternative Therapies in Health and Medicine, vol. 17, no. 5, 2011, pp. 8-13.
Jones AY, Ngai SP, Hui-Chan CW, et al. Acute Effects of Acu-TENS on FEV1 and Blood Β-endorphin Level in Chronic Obstructive Pulmonary Disease. Altern Ther Health Med. 2011;17(5):8-13.
Jones, A. Y., Ngai, S. P., Hui-Chan, C. W., & Yu, H. P. (2011). Acute Effects of Acu-TENS on FEV1 and Blood Β-endorphin Level in Chronic Obstructive Pulmonary Disease. Alternative Therapies in Health and Medicine, 17(5), 8-13.
Jones AY, et al. Acute Effects of Acu-TENS On FEV1 and Blood Β-endorphin Level in Chronic Obstructive Pulmonary Disease. Altern Ther Health Med. 2011 Sep-Oct;17(5):8-13. PubMed PMID: 22314671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute Effects of Acu-TENS on FEV1 and Blood Β-endorphin Level in Chronic Obstructive Pulmonary Disease. AU - Jones,Alice Y M, AU - Ngai,Shirley P C, AU - Hui-Chan,Christina W Y, AU - Yu,Homer P M, PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2016/4/24/medline SP - 8 EP - 13 JF - Alternative therapies in health and medicine JO - Altern Ther Health Med VL - 17 IS - 5 N2 - Background Pharmacotherapy is the mainstay of dyspnea management in patients with chronic obstructive pulmonary disease (COPD). Undesirable side effects have led to the application of alternative treatment strategies such as acupuncture. Our previous study showed that transcutaneous electrical nerve stimulation over acupuncture points (Acu-TENS), a noninvasive modality, can reduce dyspnea symptoms in patients with COPD, but the underlying mechanism is unknown. Primary Study Objective This study investigated the effect of acu-TENS on forced expiratory volume in one second (FEV1), dyspnea, and Β-endorphin levels in patients with COPD. Design A double-blinded randomized controlled trial Setting: Hospital outpatient clinic Participants Forty-four subjects diagnosed with COPD Intervention Participants were randomly assigned to receive either acu-TENS or placebo-TENS on Dingchuan (EX-B1) for 45 minutes. Outcome Measures FEV1, forced vital capacity (FVC), dyspnea visual analogue score (DVAS), respiratory rate (RR), and blood Β-endorphin levels were measured before and after therapeutic intervention. Results Our findings showed that the increase in FEV1 was 24.2% greater in the acu-TENS group than the placebo group (P < .0001). The decrease in RR and DVAS was also more in the acu-TENS group by 14.2% (P < .0001) and 20.7% (P = .006), respectively. The postintervention increase in Β-endorphin was significantly higher in the acu-TENS than the placebo group (18.3%) (P = .027). Furthermore, the percentage reduction in RR correlated with the increase in Β-endorphin (R = -0.477, P = .033). Conclusion An improvement in FEV1 and dyspnea score at the end of Acu-TENS treatment was associated with a concurrent increase in b-endorphin level in patients with COPD. SN - 1078-6791 UR - https://www.unboundmedicine.com/medline/citation/22314671/Acute_Effects_of_Acu_TENS_on_FEV1_and_Blood_Β_endorphin_Level_in_Chronic_Obstructive_Pulmonary_Disease_ L2 - http://www.diseaseinfosearch.org/result/7979 DB - PRIME DP - Unbound Medicine ER -