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Prenatal cortisol exposure predicts infant cortisol response to acute stress.
Dev Psychobiol. 2013 Mar; 55(2):145-55.DP

Abstract

Experimental animal findings suggest that early stress and glucocorticoid exposure may program the function of the hypothalamic-pituitary-adrenal (HPA) axis in the offspring. The extension of these findings to human development is not yet clear. A prospective longitudinal study was conducted on 125 mothers and their normally developing children. Amniotic fluid was obtained at, on average, 17.2 weeks gestation; infant behavior and cortisol response to a separation-reunion stress was assessed at 17 months. Amniotic fluid cortisol predicted infant cortisol response to separation-reunion stress: infants who were exposed to higher levels of cortisol in utero showed higher pre-stress cortisol values and blunted response to stress exposure. The association was independent of prenatal, obstetric, and socioeconomic factors and child-parent attachment. The findings provide some of the strongest data in humans that HPA axis functioning in the child may be predicted from prenatal cortisol exposure.

Authors+Show Affiliations

Department of Psychiatry, Wynne Center for Family Research, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, New York 14642, USA. tom_oconnor@urmc.rochester.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22315044

Citation

O'Connor, Thomas G., et al. "Prenatal Cortisol Exposure Predicts Infant Cortisol Response to Acute Stress." Developmental Psychobiology, vol. 55, no. 2, 2013, pp. 145-55.
O'Connor TG, Bergman K, Sarkar P, et al. Prenatal cortisol exposure predicts infant cortisol response to acute stress. Dev Psychobiol. 2013;55(2):145-55.
O'Connor, T. G., Bergman, K., Sarkar, P., & Glover, V. (2013). Prenatal cortisol exposure predicts infant cortisol response to acute stress. Developmental Psychobiology, 55(2), 145-55. https://doi.org/10.1002/dev.21007
O'Connor TG, et al. Prenatal Cortisol Exposure Predicts Infant Cortisol Response to Acute Stress. Dev Psychobiol. 2013;55(2):145-55. PubMed PMID: 22315044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal cortisol exposure predicts infant cortisol response to acute stress. AU - O'Connor,Thomas G, AU - Bergman,Kristin, AU - Sarkar,Pampa, AU - Glover,Vivette, Y1 - 2012/02/07/ PY - 2011/09/23/received PY - 2011/12/20/accepted PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2013/7/20/medline SP - 145 EP - 55 JF - Developmental psychobiology JO - Dev Psychobiol VL - 55 IS - 2 N2 - Experimental animal findings suggest that early stress and glucocorticoid exposure may program the function of the hypothalamic-pituitary-adrenal (HPA) axis in the offspring. The extension of these findings to human development is not yet clear. A prospective longitudinal study was conducted on 125 mothers and their normally developing children. Amniotic fluid was obtained at, on average, 17.2 weeks gestation; infant behavior and cortisol response to a separation-reunion stress was assessed at 17 months. Amniotic fluid cortisol predicted infant cortisol response to separation-reunion stress: infants who were exposed to higher levels of cortisol in utero showed higher pre-stress cortisol values and blunted response to stress exposure. The association was independent of prenatal, obstetric, and socioeconomic factors and child-parent attachment. The findings provide some of the strongest data in humans that HPA axis functioning in the child may be predicted from prenatal cortisol exposure. SN - 1098-2302 UR - https://www.unboundmedicine.com/medline/citation/22315044/Prenatal_cortisol_exposure_predicts_infant_cortisol_response_to_acute_stress_ L2 - https://doi.org/10.1002/dev.21007 DB - PRIME DP - Unbound Medicine ER -