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Milk and dairy consumption among men with prostate cancer and risk of metastases and prostate cancer death.

Abstract

BACKGROUND

Whether milk and dairy intake after a prostate cancer diagnosis is associated with a poorer prognosis is unknown. We investigated postdiagnostic milk and dairy intake in relation to risk of lethal prostate cancer (metastases and prostate cancer death) among participants in the Health Professionals Follow-Up Study.

METHODS

The cohort consisted of 3,918 men diagnosed with apparently localized prostate cancer between 1986 and 2006, and followed to 2008. Data on milk and dairy intake were available from repeated questionnaires. We used Cox proportional hazards models to calculate HRs and 95% CIs of the association between postdiagnostic milk and dairy intake and prostate cancer outcomes.

RESULTS

We ascertained 229 prostate cancer deaths and an additional 69 metastases during follow-up. In multivariate analysis, total milk and dairy intakes after diagnosis were not associated with a greater risk of lethal prostate cancer. Men with the highest versus lowest intake of whole milk were at an increased risk of progression (HR = 2.15, 95% CI: 1.28-3.60; P(trend) < 0.01). Men in the highest versus lowest quintile of low-fat dairy intake were at a decreased risk of progression (HR = 0.62; 95% CI: 0.40-0.95; P(trend) = 0.07).

CONCLUSIONS

With the exception of whole milk, our results suggest that milk and dairy intake after a prostate cancer diagnosis is not associated with an increased risk of lethal prostate cancer.

IMPACT

This is the first larger prospective study investigating the relation between postdiagnostic milk and dairy intake and risk of lethal prostate cancer.

Authors+Show Affiliations

Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. apetter s@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22315365

Citation

Pettersson, Andreas, et al. "Milk and Dairy Consumption Among Men With Prostate Cancer and Risk of Metastases and Prostate Cancer Death." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 21, no. 3, 2012, pp. 428-36.
Pettersson A, Kasperzyk JL, Kenfield SA, et al. Milk and dairy consumption among men with prostate cancer and risk of metastases and prostate cancer death. Cancer Epidemiol Biomarkers Prev. 2012;21(3):428-36.
Pettersson, A., Kasperzyk, J. L., Kenfield, S. A., Richman, E. L., Chan, J. M., Willett, W. C., ... Giovannucci, E. L. (2012). Milk and dairy consumption among men with prostate cancer and risk of metastases and prostate cancer death. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 21(3), pp. 428-36. doi:10.1158/1055-9965.EPI-11-1004.
Pettersson A, et al. Milk and Dairy Consumption Among Men With Prostate Cancer and Risk of Metastases and Prostate Cancer Death. Cancer Epidemiol Biomarkers Prev. 2012;21(3):428-36. PubMed PMID: 22315365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk and dairy consumption among men with prostate cancer and risk of metastases and prostate cancer death. AU - Pettersson,Andreas, AU - Kasperzyk,Julie L, AU - Kenfield,Stacey A, AU - Richman,Erin L, AU - Chan,June M, AU - Willett,Walter C, AU - Stampfer,Meir J, AU - Mucci,Lorelei A, AU - Giovannucci,Edward L, Y1 - 2012/02/07/ PY - 2012/2/9/entrez PY - 2012/2/9/pubmed PY - 2012/7/13/medline SP - 428 EP - 36 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 21 IS - 3 N2 - BACKGROUND: Whether milk and dairy intake after a prostate cancer diagnosis is associated with a poorer prognosis is unknown. We investigated postdiagnostic milk and dairy intake in relation to risk of lethal prostate cancer (metastases and prostate cancer death) among participants in the Health Professionals Follow-Up Study. METHODS: The cohort consisted of 3,918 men diagnosed with apparently localized prostate cancer between 1986 and 2006, and followed to 2008. Data on milk and dairy intake were available from repeated questionnaires. We used Cox proportional hazards models to calculate HRs and 95% CIs of the association between postdiagnostic milk and dairy intake and prostate cancer outcomes. RESULTS: We ascertained 229 prostate cancer deaths and an additional 69 metastases during follow-up. In multivariate analysis, total milk and dairy intakes after diagnosis were not associated with a greater risk of lethal prostate cancer. Men with the highest versus lowest intake of whole milk were at an increased risk of progression (HR = 2.15, 95% CI: 1.28-3.60; P(trend) < 0.01). Men in the highest versus lowest quintile of low-fat dairy intake were at a decreased risk of progression (HR = 0.62; 95% CI: 0.40-0.95; P(trend) = 0.07). CONCLUSIONS: With the exception of whole milk, our results suggest that milk and dairy intake after a prostate cancer diagnosis is not associated with an increased risk of lethal prostate cancer. IMPACT: This is the first larger prospective study investigating the relation between postdiagnostic milk and dairy intake and risk of lethal prostate cancer. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/22315365/Milk_and_dairy_consumption_among_men_with_prostate_cancer_and_risk_of_metastases_and_prostate_cancer_death_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=22315365 DB - PRIME DP - Unbound Medicine ER -