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Characterization of acute kidney injury in hospitalized dogs and evaluation of a veterinary acute kidney injury staging system.

Abstract

OBJECTIVE

To retrospectively apply standards characterizing acute kidney injury (AKI) used in human medicine to a population of critically ill hospitalized dogs in order to identify dogs with potential AKI based on subtle increases in plasma creatinine concentration.

DESIGN

Retrospective study.

SETTING

University Veterinary Medical Teaching Hospital.

ANIMALS

One hundred and sixty-four client-owned dogs admitted to the intensive care unit.

INTERVENTIONS

None.

MEASUREMENTS AND MAIN RESULTS

Medical records of 164 dogs meeting the study inclusion criteria were reviewed to identify age, results of creatinine measurements, discharge status, length of stay, performance of general anesthesia, number of diagnoses, and calculated survival prediction index scores (SPI2). A veterinary AKI (VAKI) staging system was retrospectively applied to classify dogs based on increase in creatinine concentration from baseline as follows: stage 0 (S0; <150%), stage 1 (S1; 150-199% or ≥26.5 μmol/L [≥0.3 mg/dL]), stage 2 (S2; 200-299%), or stage 3 (S3; ≥300%). Of the dogs evaluated, 140/164 were VAKI stage S0, 19/164 were classified as S1, 3/164 as S2, and 2/164 were S3. Mortality rate was greater for S1-3 (13/24; 54.2%) compared to S0 dogs (22/140; 15.7%) (P < 0.0001). Length of stay, general anesthesia, and number of diagnoses were not associated with survival. In a logistic regression model, stage and age were jointly, significantly associated with mortality (P = 0.0002 and P = 0.0330, respectively). Mean SPI2 scores were not different between S0 (0.52) and S1 (0.59) dogs (P = 0.23). Only 4/19 (21%) of S1 dogs had a peak plasma creatinine concentration above the laboratory reference interval.

CONCLUSIONS

Dogs meeting VAKI stage 1-3 criteria were less likely to survive to discharge. Small increases in plasma creatinine concentration may be clinically relevant even when absolute values are within reference intervals.

Authors+Show Affiliations

Department of Veterinary Medicine and Surgery, University of Missouri, College of Veterinary Medicine, Columbia, MO 65211, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22316258

Citation

Thoen, Meredith E., and Marie E. Kerl. "Characterization of Acute Kidney Injury in Hospitalized Dogs and Evaluation of a Veterinary Acute Kidney Injury Staging System." Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), vol. 21, no. 6, 2011, pp. 648-57.
Thoen ME, Kerl ME. Characterization of acute kidney injury in hospitalized dogs and evaluation of a veterinary acute kidney injury staging system. J Vet Emerg Crit Care (San Antonio). 2011;21(6):648-57.
Thoen, M. E., & Kerl, M. E. (2011). Characterization of acute kidney injury in hospitalized dogs and evaluation of a veterinary acute kidney injury staging system. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), 21(6), pp. 648-57. doi:10.1111/j.1476-4431.2011.00689.x.
Thoen ME, Kerl ME. Characterization of Acute Kidney Injury in Hospitalized Dogs and Evaluation of a Veterinary Acute Kidney Injury Staging System. J Vet Emerg Crit Care (San Antonio). 2011;21(6):648-57. PubMed PMID: 22316258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of acute kidney injury in hospitalized dogs and evaluation of a veterinary acute kidney injury staging system. AU - Thoen,Meredith E, AU - Kerl,Marie E, Y1 - 2011/11/21/ PY - 2010/10/27/received PY - 2011/09/27/accepted PY - 2012/2/10/entrez PY - 2012/2/10/pubmed PY - 2012/5/25/medline SP - 648 EP - 57 JF - Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) JO - J Vet Emerg Crit Care (San Antonio) VL - 21 IS - 6 N2 - OBJECTIVE: To retrospectively apply standards characterizing acute kidney injury (AKI) used in human medicine to a population of critically ill hospitalized dogs in order to identify dogs with potential AKI based on subtle increases in plasma creatinine concentration. DESIGN: Retrospective study. SETTING: University Veterinary Medical Teaching Hospital. ANIMALS: One hundred and sixty-four client-owned dogs admitted to the intensive care unit. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Medical records of 164 dogs meeting the study inclusion criteria were reviewed to identify age, results of creatinine measurements, discharge status, length of stay, performance of general anesthesia, number of diagnoses, and calculated survival prediction index scores (SPI2). A veterinary AKI (VAKI) staging system was retrospectively applied to classify dogs based on increase in creatinine concentration from baseline as follows: stage 0 (S0; <150%), stage 1 (S1; 150-199% or ≥26.5 μmol/L [≥0.3 mg/dL]), stage 2 (S2; 200-299%), or stage 3 (S3; ≥300%). Of the dogs evaluated, 140/164 were VAKI stage S0, 19/164 were classified as S1, 3/164 as S2, and 2/164 were S3. Mortality rate was greater for S1-3 (13/24; 54.2%) compared to S0 dogs (22/140; 15.7%) (P < 0.0001). Length of stay, general anesthesia, and number of diagnoses were not associated with survival. In a logistic regression model, stage and age were jointly, significantly associated with mortality (P = 0.0002 and P = 0.0330, respectively). Mean SPI2 scores were not different between S0 (0.52) and S1 (0.59) dogs (P = 0.23). Only 4/19 (21%) of S1 dogs had a peak plasma creatinine concentration above the laboratory reference interval. CONCLUSIONS: Dogs meeting VAKI stage 1-3 criteria were less likely to survive to discharge. Small increases in plasma creatinine concentration may be clinically relevant even when absolute values are within reference intervals. SN - 1476-4431 UR - https://www.unboundmedicine.com/medline/citation/22316258/Characterization_of_acute_kidney_injury_in_hospitalized_dogs_and_evaluation_of_a_veterinary_acute_kidney_injury_staging_system_ L2 - https://doi.org/10.1111/j.1476-4431.2011.00689.x DB - PRIME DP - Unbound Medicine ER -