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[Clinical observation of therapeutic effect of extracorporeal membrane oxygenation in patients with acute respiratory distress syndrome].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Feb; 24(2):83-5.ZW

Abstract

OBJECTIVE

To investigate the therapeutic effects and safety of extracorporeal membrane oxygenation (ECMO) in patients with acute respiratory distress syndrome (ARDS).

METHODS

ECMO were initiated in 6 patients with ARDS, not responding to conventional mechanical ventilation. Oxygenation status, positive end-expiratory pressure (PEEP) level, and fraction of inspired oxygen [FiO(2)] were compared before and after treatment with ECMO, while the adverse effects of ECMO were recorded.

RESULTS

In 6 cases, pulse blood oxygen saturation [SpO(2)] was elevated (0.45-0.92 up to 0.94-1.00), PEEP level [cm H(2)O, 1 cm H(2)O=0.098 kPa] and [FiO(2)] were lowered [PEEP: 10.0-22.0 down to 4.0-15.0; FiO(2): 1.00 down to 0.30-0.60] after treatment with ECMO. Of 6 cases, 2 patients with severe influenza A/H1N1 pneumonia finally died of shock; 1 patient with severe influenza A/H1N1 pneumonia and 1 patient with Klebsiella pneumoniae pneumonia were withdrawn from ECMO treatment because of deterioration of the disease. One patient suffering from Cytomegalovirus pneumonia and another with Acinetobacter baumannii pneumonia were successfully discharged from hospital with recovery. The main complications were bleeding and hemolysis.

CONCLUSIONS

ECMO could improve gas exchange, oxygenation and partially replace pulmonary function. Patients with ARDS should be treated with ECMO early if artificial ventilation treatment was unresponsive.

Authors+Show Affiliations

Wang CH
Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Institute of Respiratory Disease, Beijing 100020, China.
Tong ZH
No affiliation info available
Zhan QY
No affiliation info available
Sun B
No affiliation info available
Quan JY
No affiliation info available
Li CH
No affiliation info available

MeSH

AdultExtracorporeal Membrane OxygenationFemaleHumansMaleMiddle AgedRespiration, ArtificialRespiratory Distress SyndromeRetrospective StudiesTreatment OutcomeYoung Adult

Pub Type(s)

Journal Article

Language

chi

PubMed ID

22316533

Citation

Wang, Chuan-hai, et al. "[Clinical Observation of Therapeutic Effect of Extracorporeal Membrane Oxygenation in Patients With Acute Respiratory Distress Syndrome]." Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, vol. 24, no. 2, 2012, pp. 83-5.
Wang CH, Tong ZH, Zhan QY, et al. [Clinical observation of therapeutic effect of extracorporeal membrane oxygenation in patients with acute respiratory distress syndrome]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012;24(2):83-5.
Wang, C. H., Tong, Z. H., Zhan, Q. Y., Sun, B., Quan, J. Y., & Li, C. H. (2012). [Clinical observation of therapeutic effect of extracorporeal membrane oxygenation in patients with acute respiratory distress syndrome]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 24(2), 83-5.
Wang CH, et al. [Clinical Observation of Therapeutic Effect of Extracorporeal Membrane Oxygenation in Patients With Acute Respiratory Distress Syndrome]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012;24(2):83-5. PubMed PMID: 22316533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical observation of therapeutic effect of extracorporeal membrane oxygenation in patients with acute respiratory distress syndrome]. AU - Wang,Chuan-hai, AU - Tong,Zhao-hui, AU - Zhan,Qing-yuan, AU - Sun,Bing, AU - Quan,Jing-yu, AU - Li,Cheng-hong, PY - 2012/2/10/entrez PY - 2012/2/10/pubmed PY - 2013/2/16/medline SP - 83 EP - 5 JF - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue JO - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue VL - 24 IS - 2 N2 - OBJECTIVE: To investigate the therapeutic effects and safety of extracorporeal membrane oxygenation (ECMO) in patients with acute respiratory distress syndrome (ARDS). METHODS: ECMO were initiated in 6 patients with ARDS, not responding to conventional mechanical ventilation. Oxygenation status, positive end-expiratory pressure (PEEP) level, and fraction of inspired oxygen [FiO(2)] were compared before and after treatment with ECMO, while the adverse effects of ECMO were recorded. RESULTS: In 6 cases, pulse blood oxygen saturation [SpO(2)] was elevated (0.45-0.92 up to 0.94-1.00), PEEP level [cm H(2)O, 1 cm H(2)O=0.098 kPa] and [FiO(2)] were lowered [PEEP: 10.0-22.0 down to 4.0-15.0; FiO(2): 1.00 down to 0.30-0.60] after treatment with ECMO. Of 6 cases, 2 patients with severe influenza A/H1N1 pneumonia finally died of shock; 1 patient with severe influenza A/H1N1 pneumonia and 1 patient with Klebsiella pneumoniae pneumonia were withdrawn from ECMO treatment because of deterioration of the disease. One patient suffering from Cytomegalovirus pneumonia and another with Acinetobacter baumannii pneumonia were successfully discharged from hospital with recovery. The main complications were bleeding and hemolysis. CONCLUSIONS: ECMO could improve gas exchange, oxygenation and partially replace pulmonary function. Patients with ARDS should be treated with ECMO early if artificial ventilation treatment was unresponsive. SN - 1003-0603 UR - https://www.unboundmedicine.com/medline/citation/22316533/[Clinical_observation_of_therapeutic_effect_of_extracorporeal_membrane_oxygenation_in_patients_with_acute_respiratory_distress_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/210 DB - PRIME DP - Unbound Medicine ER -