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Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials.
Atherosclerosis 2012; 221(2):536-43A

Abstract

OBJECTIVE

Inverse association was reported between omega-3 fatty acids (FAs) supplementation and the risk of cardiovascular disease. Identifying the effect of omega-3 FAs on endothelial function may contribute to explain the association. We conducted a meta-analysis to assess the effect of omega-3 FAs supplementation on endothelial function, as measured by flow-mediated dilation (FMD) and endothelium-independent vasodilation (EIV).

METHODS

Randomized placebo-controlled trials (RCTs) were identified from the databases of PubMed, EMBASE and Cochrane library by two investigators and the pooled effects were measured by weighted mean difference (WMD), together with 95% confidence intervals (CIs). Subgroup and meta-regression analyses were used to explore the source of between-study heterogeneity.

RESULTS

Totally 16 eligible studies involving 901 participants were finally included in meta-analysis. Compared with placebo, omega-3 FAs supplementation significantly increased FMD by 2.30% (95% CI: 0.89-3.72%, P = 0.001), at a dose ranging from 0.45 to 4.5 g/d over a median of 56 days. Subgroup analyses suggested that the effect of omega-3 FAs on FMD might be modified by the health status of the participants or the dose of supplementation. Sensitivity analyses indicated that the protective effect of omega-3 on endothelial function was robust. No significant change in EIV was observed after omega-3 FAs supplementation (WMD: 0.57%; 95% CI: -0.88 to 2.01%; P = 0.442).

CONCLUSION

Supplementation of omega-3 fatty acids significantly improves the endothelial function without affecting endothelium-independent dilation.

Authors+Show Affiliations

State Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital & National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22317966

Citation

Wang, Qianqian, et al. "Effect of Omega-3 Fatty Acids Supplementation On Endothelial Function: a Meta-analysis of Randomized Controlled Trials." Atherosclerosis, vol. 221, no. 2, 2012, pp. 536-43.
Wang Q, Liang X, Wang L, et al. Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials. Atherosclerosis. 2012;221(2):536-43.
Wang, Q., Liang, X., Wang, L., Lu, X., Huang, J., Cao, J., ... Gu, D. (2012). Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials. Atherosclerosis, 221(2), pp. 536-43. doi:10.1016/j.atherosclerosis.2012.01.006.
Wang Q, et al. Effect of Omega-3 Fatty Acids Supplementation On Endothelial Function: a Meta-analysis of Randomized Controlled Trials. Atherosclerosis. 2012;221(2):536-43. PubMed PMID: 22317966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials. AU - Wang,Qianqian, AU - Liang,Xiaohua, AU - Wang,Laiyuan, AU - Lu,Xiangfeng, AU - Huang,Jianfeng, AU - Cao,Jie, AU - Li,Hongfan, AU - Gu,Dongfeng, Y1 - 2012/01/20/ PY - 2011/08/25/received PY - 2011/11/29/revised PY - 2012/01/02/accepted PY - 2012/2/10/entrez PY - 2012/2/10/pubmed PY - 2012/7/27/medline SP - 536 EP - 43 JF - Atherosclerosis JO - Atherosclerosis VL - 221 IS - 2 N2 - OBJECTIVE: Inverse association was reported between omega-3 fatty acids (FAs) supplementation and the risk of cardiovascular disease. Identifying the effect of omega-3 FAs on endothelial function may contribute to explain the association. We conducted a meta-analysis to assess the effect of omega-3 FAs supplementation on endothelial function, as measured by flow-mediated dilation (FMD) and endothelium-independent vasodilation (EIV). METHODS: Randomized placebo-controlled trials (RCTs) were identified from the databases of PubMed, EMBASE and Cochrane library by two investigators and the pooled effects were measured by weighted mean difference (WMD), together with 95% confidence intervals (CIs). Subgroup and meta-regression analyses were used to explore the source of between-study heterogeneity. RESULTS: Totally 16 eligible studies involving 901 participants were finally included in meta-analysis. Compared with placebo, omega-3 FAs supplementation significantly increased FMD by 2.30% (95% CI: 0.89-3.72%, P = 0.001), at a dose ranging from 0.45 to 4.5 g/d over a median of 56 days. Subgroup analyses suggested that the effect of omega-3 FAs on FMD might be modified by the health status of the participants or the dose of supplementation. Sensitivity analyses indicated that the protective effect of omega-3 on endothelial function was robust. No significant change in EIV was observed after omega-3 FAs supplementation (WMD: 0.57%; 95% CI: -0.88 to 2.01%; P = 0.442). CONCLUSION: Supplementation of omega-3 fatty acids significantly improves the endothelial function without affecting endothelium-independent dilation. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/22317966/Effect_of_omega_3_fatty_acids_supplementation_on_endothelial_function:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(12)00010-X DB - PRIME DP - Unbound Medicine ER -