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Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats.
Hum Exp Toxicol. 2012 Jul; 31(7):726-33.HE

Abstract

AIM

Oxidative stress has been implicated as a potential responsible mechanism in the pathogenesis of vancomycin (VCM)-induced renal toxicity. Therefore, we aimed to investigate the protective effect of thymoquinone (TQ) against VCM-induced nephrotoxicity by tissue oxidant/antioxidant parameters and histological changes in rats.

MATERIALS AND METHODS

Wistar albino rats were randomly separated into four groups consisting of seven rats per group. The groups had normal saline (control group), VCM, VCM and TQ and TQ, respectively. VCM was injected intraperitoneally at a dose of 200 mg/kg and continued at 12-h intervals for 7 days. TQ was injected intraperitoneally at a dose of 10 mg/kg and continued at 24 h intervals for 8 days. Animals were killed and blood samples were analyzed for the levels of serum blood urea nitrogen (BUN) and creatinine (Cr). Kidney specimens were analyzed for levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) as well as for histopathological changes.

RESULTS

We found that the levels of serum BUN, Cr and kidney tissue MDA were increased in the VCM group. Activities of SOD and GSH-Px in kidney tissue were decreased. TQ administration ameliorated significantly these changes.

CONCLUSION

These results indicate that the TQ produces a protective mechanism against VCM-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

Authors+Show Affiliations

Department of Pediatrics, Mustafa Kemal University, Hatay, Turkey. fatmagulbasarslan@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22318306

Citation

Basarslan, Fatmagul, et al. "Protective Effects of Thymoquinone On Vancomycin-induced Nephrotoxicity in Rats." Human & Experimental Toxicology, vol. 31, no. 7, 2012, pp. 726-33.
Basarslan F, Yilmaz N, Ates S, et al. Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats. Hum Exp Toxicol. 2012;31(7):726-33.
Basarslan, F., Yilmaz, N., Ates, S., Ozgur, T., Tutanc, M., Motor, V. K., Arica, V., Yilmaz, C., Inci, M., & Buyukbas, S. (2012). Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats. Human & Experimental Toxicology, 31(7), 726-33. https://doi.org/10.1177/0960327111433185
Basarslan F, et al. Protective Effects of Thymoquinone On Vancomycin-induced Nephrotoxicity in Rats. Hum Exp Toxicol. 2012;31(7):726-33. PubMed PMID: 22318306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats. AU - Basarslan,Fatmagul, AU - Yilmaz,N, AU - Ates,S, AU - Ozgur,T, AU - Tutanc,M, AU - Motor,V K, AU - Arica,V, AU - Yilmaz,C, AU - Inci,M, AU - Buyukbas,S, Y1 - 2012/02/08/ PY - 2012/2/10/entrez PY - 2012/2/10/pubmed PY - 2012/12/14/medline SP - 726 EP - 33 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 31 IS - 7 N2 - AIM: Oxidative stress has been implicated as a potential responsible mechanism in the pathogenesis of vancomycin (VCM)-induced renal toxicity. Therefore, we aimed to investigate the protective effect of thymoquinone (TQ) against VCM-induced nephrotoxicity by tissue oxidant/antioxidant parameters and histological changes in rats. MATERIALS AND METHODS: Wistar albino rats were randomly separated into four groups consisting of seven rats per group. The groups had normal saline (control group), VCM, VCM and TQ and TQ, respectively. VCM was injected intraperitoneally at a dose of 200 mg/kg and continued at 12-h intervals for 7 days. TQ was injected intraperitoneally at a dose of 10 mg/kg and continued at 24 h intervals for 8 days. Animals were killed and blood samples were analyzed for the levels of serum blood urea nitrogen (BUN) and creatinine (Cr). Kidney specimens were analyzed for levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) as well as for histopathological changes. RESULTS: We found that the levels of serum BUN, Cr and kidney tissue MDA were increased in the VCM group. Activities of SOD and GSH-Px in kidney tissue were decreased. TQ administration ameliorated significantly these changes. CONCLUSION: These results indicate that the TQ produces a protective mechanism against VCM-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/22318306/Protective_effects_of_thymoquinone_on_vancomycin_induced_nephrotoxicity_in_rats_ DB - PRIME DP - Unbound Medicine ER -